Adjuvant

Adjuvant

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Article Count - 6
Cumulative Knowledge - 18

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Quick Summary: Current access displays 2 out of 7 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Vaccine-induced Toxicity	14	4	Log in \| Sign up
Immune Dysregulation: TH1/TH2 imbalance	11	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 3 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Carcinogenic	2	1	Log in \| Sign up
Endocrine Disruptor	2	1	Log in \| Sign up

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View the Evidence: Problem Substances

The association with DTwP vaccines and increased infant mortality in females may be due to vaccine adjuvants and Th2 polarizing effects.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Trop Med. 2011 ;2011:706304. Epub 2011 May 5. PMID: 21760811

Article Published Date : Jan 01, 2011

Study Type : Human Study

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Diseases : Immune Dysregulation: TH1/TH2 imbalance : CK(146) : AC(36), Infant Mortality : CK(229) : AC(23), Vaccine-induced Toxicity : CK(1130) : AC(163)

Anti Therapeutic Actions : Vaccination: All : CK(3830) : AC(302), Vaccination: Diphtheria-Pertussis-Tetanus : CK(283) : AC(31), Vaccination: Pertussis : CK(116) : AC(14), Vaccination: Tetanus : CK(48) : AC(8), Vaccinaton: Diptheria : CK(50) : AC(2)

Problem Substances : Adjuvant : CK(18) : AC(6), Aluminum Hydroxide : CK(56) : AC(14), Vaccine Adjuvants : CK(383) : AC(77)

Induction of autoantibodies by mineral oils considered nontoxic also may have pathogenetic implications in human autoimmune diseases.

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Pubmed Data : Toxicol Sci. 2004 Apr;78(2):222-8. Epub 2004 Jan 12. PMID: 14718649

Article Published Date : Apr 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Autoimmune Diseases : CK(5317) : AC(779)

Problem Substances : Adjuvant : CK(18) : AC(6), Freund adjuvant : CK(21) : AC(11), Hexadecane : CK(4) : AC(2), Mineral Oil : CK(178) : AC(39), Squalene : CK(4) : AC(2)

Tween 80 exposure in newborn rats results in disruption of female reproductive organs.

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Pubmed Data : Food Chem Toxicol. 1993 Mar;31(3):183-90. PMID: 8473002

Article Published Date : Mar 01, 1993

Study Type : Animal Study

Additional Links

Problem Substances : Adjuvant : CK(18) : AC(6), Tween 80 : CK(2) : AC(1)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Endocrine Disruptor : CK(478) : AC(81)

Vaccine adjuvants can contribute to the pathogenesis of autoimmune diseases such as lupus.

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Pubmed Data : J Autoimmun. 2003 Aug;21(1):1-9. PMID: 12892730

Article Published Date : Aug 01, 2003

Study Type : Animal Study

Additional Links

Diseases : Autoimmune Diseases : CK(5317) : AC(779), Lupus Erythematosus: Systemic : CK(949) : AC(53), Vaccine-induced Toxicity : CK(1130) : AC(163)

Problem Substances : Adjuvant : CK(18) : AC(6), Freund adjuvant : CK(21) : AC(11), Mineral Oil : CK(178) : AC(39), Pristane : CK(4) : AC(2), Squalene : CK(4) : AC(2)

Adverse Pharmacological Actions : Immunotoxic : CK(230) : AC(38)

Adjuvants in vaccines may trigger innate cells response by toll-like receptors, thus eliciting a possible non-IgE mediated allergy phenomenon or causing B-cell activation and autoimmunity.

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Pubmed Data : Hum Vaccin. 2011 Aug 1 ;7(8). Epub 2011 Aug 1. PMID: 21785282

Article Published Date : Aug 01, 2011

Study Type : Review

Additional Links

Diseases : Autoimmune Diseases : CK(5317) : AC(779), Hypersensitivity : CK(64) : AC(15), Immune Disorders: B-Cell Over-Activity : CK(2) : AC(2), Immune Dysregulation: TH1/TH2 imbalance : CK(146) : AC(36), Vaccine-induced Toxicity : CK(1130) : AC(163)

Anti Therapeutic Actions : Vaccination: All : CK(3830) : AC(302)

Problem Substances : Adjuvant : CK(18) : AC(6)

Compounds commonly used as preservatives in US licensed vaccine/biological preparations exhibit significant toxicity and may not comply with the US Code of Federal Regulations for preservatives.

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Pubmed Data : Med Sci Monit. 2010 Apr 28;16(5):SR21-7. PMID: 20424565

Article Published Date : Apr 28, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Vaccine-induced Toxicity : CK(1130) : AC(163)

Problem Substances : 2-phenoxyethanol : CK(2) : AC(2), Adjuvant : CK(18) : AC(6), Benzethonium chloride : CK(2) : AC(2), Phenol : CK(2) : AC(2), Thimerosal : CK(216) : AC(23)

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