Adrenaline

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View the Evidence: Problem Substances

Adrenaline induces chemoresistance in HT-29 colon adenocarcinoma cells.

Pubmed Data : Cancer Genet Cytogenet. 2009 Apr 15 ;190(2):81-7. PMID: 19380024
Article Published Date : Apr 15, 2009
Study Type : In Vitro Study
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Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Colon Cancer : CK(895) : AC(233)
Anti Therapeutic Actions : Stress : CK(30) : AC(9)
Problem Substances : Adrenaline : CK(1) : AC(1)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Chemoresistance upregulation : CK(1) : AC(1)

Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation.

Pubmed Data : J Cell Biochem. 2008 Sep 1 ;105(1):53-60. PMID: 18452159
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Esophageal Cancer : CK(328) : AC(55), Squamous cell carcinoma : CK(79) : AC(36)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
Anti Therapeutic Actions : Stress : CK(30) : AC(9)
Problem Substances : Adrenaline : CK(1) : AC(1)
Adverse Pharmacological Actions : Chemoresistance upregulation : CK(1) : AC(1)

Psychological stress induces chemoresistance in breast cancer by upregulating mdr1.

Pubmed Data : Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):888-97. PMID: 15752739
Article Published Date : Apr 15, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621), Cancers: Drug Resistant : CK(225) : AC(147), Cancers: Multi-Drug Resistant : CK(92) : AC(73)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Anti Therapeutic Actions : Stress : CK(30) : AC(9)
Problem Substances : Adrenaline : CK(1) : AC(1)
Adverse Pharmacological Actions : Chemoresistance upregulation : CK(1) : AC(1), Multidrug resistance 1 (p-glycoprotein 1) upregulation : CK(1) : AC(1)

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