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3 Diseases Researched for Antipsychotic Drugs
NameACCKFocus
Endocrine Diseases110Locked
Endocrine Imbalances110Locked
Hormone Imbalances110Locked
1 Adverse Pharmacological Actions Researched for Antipsychotic Drugs
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Endocrine Disruptor110Locked

View the Evidence:
28 Abstracts with Antipsychotic Drugs Research

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There is good evidence to support the existence of both metabolic and neurological adverse effects in children treated with second-generation antipsychotics.Jul 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Saf. 2011 Aug 1 ;34(8):651-68. PMID: 21751826
Article Published Date : Jul 31, 2011
Study Type : Meta Analysis, Review
Additional Links
Diseases : Metabolic Diseases
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs, Risperidone
Adverse Pharmacological Actions : Neurotoxic
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Users of first-generation antipsychotics were at a higher risk of hip fracture.Mar 31, 2017

Pubmed Data : Osteoporos Int. 2017 Apr ;28(4):1167-1178. Epub 2017 Jan 12. PMID: 28083669
Article Published Date : Mar 31, 2017
Study Type : Meta Analysis, Review
Additional Links
Diseases : Fractures: Bone, Hip Fracture
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
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An analysis of cases reported to U.S. poison control centers concerning morbidity and mortality associated with depression medications.Apr 30, 2017

Pubmed Data : Am J Psychiatry. 2017 May 1 ;174(5):438-450. Epub 2017 Jan 31. PMID: 28135844
Article Published Date : Apr 30, 2017
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk, Mortality
Problem Substances : Antidepressants, Antipsychotic Drugs, Carbamazepine, Olanzapine, Quetiapine
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An elevated serum level of C-reactive protein is associated with increased serum concentrations of the atypical antipsychotic drugs clozapine, quetiapine, and risperidone.Jun 02, 2015

Pubmed Data : Psychopharmacology (Berl). 2015 Jun 3. Epub 2015 Jun 3. PMID: 26032842
Article Published Date : Jun 02, 2015
Study Type : Human Study
Additional Links
Diseases : C-Reactive Protein, Inflammation
Additional Keywords : Drug Metabolism, Increased Risk
Problem Substances : Antipsychotic Drugs, Clozapine, Quetiapine, Risperidone
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Antipsychotic exposure significantly increases the risk of pulmonary embolism.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Psychiatry. 2015 ;15:92. Epub 2015 Apr 29. PMID: 25924683
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Pulmonary Embolism
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
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Antipsychotic treatment of nondiabetic drug naive schizophrenia patients was associated with adverse effects on glucose regulation. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurosci Rural Pract. 2015 Jan ;6(1):17-22. PMID: 25552846
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Schizophrenia
Additional Keywords : Glucose Dysregulation, Increased Risk
Problem Substances : Antipsychotic Drugs
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Benzodiazepine use is associated with increased mortality risk in patients with schizophreniaApr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Psychiatry. 2016 May ;77(5):661-7. PMID: 27249075
Article Published Date : Apr 30, 2016
Study Type : Human Study
Additional Links
Diseases : Schizophrenia, Suicidal Behavior
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs, Benzodiazepines
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HTR2C genetic variants may be involved in the susceptibility to metabolic syndrome in patients treated with atypical antipsychotics.Feb 12, 2018

Pubmed Data : J Pharm Pharmacol. 2018 Feb 13. Epub 2018 Feb 13. PMID: 29441581
Article Published Date : Feb 12, 2018
Study Type : Human Study
Additional Links
Diseases : Metabolic Syndrome X
Additional Keywords : Genomic Variation
Problem Substances : Antipsychotic Drugs
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Integrated therapy of acupuncture and plant extracts achieves the similar effect on infantile tourette syndrome to haloperidol tablets, but the side effects of it are less.Jan 31, 2015

Pubmed Data : Zhongguo Zhen Jiu. 2015 Feb ;35(2):141-4. PMID: 25854020
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Diseases : Tourette Syndrome
Therapeutic Actions : Acupuncture, Integrative Medicine
Additional Keywords : Plant Extracts, Therapeutic Action Superior to Drug Therapy
Problem Substances : Antipsychotic Drugs
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Psychoactive medications are associated with an increased adjusted risk of falls and fall-related injuries in hospitalized patients with cirrhosis.Mar 25, 2015

Pubmed Data : Clin Gastroenterol Hepatol. 2015 Mar 26. Epub 2015 Mar 26. PMID: 25818078
Article Published Date : Mar 25, 2015
Study Type : Human Study
Additional Links
Diseases : Cirrhosis: Liver
Additional Keywords : Elderly, Increased Risk
Problem Substances : Antipsychotic Drugs, Benzodiazepines
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Red yeast rice could be a promising agent to prevent or treat second-generation antipsychotic-induced hyperlipidemia.Mar 31, 2018

Pubmed Data : Complement Ther Med. 2018 Apr ;37:167-171. Epub 2018 Mar 15. PMID: 29609929
Article Published Date : Mar 31, 2018
Study Type : Human Study
Additional Links
Substances : Red Yeast Rice
Diseases : Hyperlipidemia
Additional Keywords : Risk Reduction
Problem Substances : Antipsychotic Drugs
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These results revealed that participants who took antipsychotics were 1.70 times more likely to complete suicide compared with those who did not.Feb 28, 2017

Pubmed Data : Pharmacopsychiatry. 2017 Mar ;50(2):69-73. Epub 2016 Sep 5. PMID: 27595297
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Diseases : Suicidal Behavior
Additional Keywords : Increased Risk
Problem Substances : Antidepressants, Antipsychotic Drugs, Benzodiazepines
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This study confirmed a greater risk of ischemic stroke with chlorpromazine and haloperidol when compared with risperidone in the elderly.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(3):e0119931. Epub 2015 Mar 19. PMID: 25790285
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Diseases : Stroke: Ischemic
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
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Use of antipsychotic drugs is associated with an increased risk of ventricular arrhythmia and sudden cardiac death.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Am Heart Assoc. 2015 Feb ;4(2). Epub 2015 Feb 23. PMID: 25713294
Article Published Date : Jan 31, 2015
Study Type : Human Study
Additional Links
Diseases : Cardiac Arrest, Cardiac Arrhythmias
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
Adverse Pharmacological Actions : Cardiotoxic
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Various medications alter salivary biomarker levels and diurnal variation in children.May 01, 2007

Pubmed Data : Child Dev. 2007 May-Jun;78(3):927-37. PMID: 17517013
Article Published Date : May 01, 2007
Study Type : Human Study
Additional Links
Diseases : Endocrine Diseases, Endocrine Imbalances, Hormone Imbalances
Problem Substances : Adderall, ADHD Drugs, Antidepressants, Antihypertensive Drugs, Antipsychotic Drugs, Concerta
Adverse Pharmacological Actions : Endocrine Disruptor
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Clinicians should be aware that neuroleptic malignant syndrome is virtually associated with all antipsychotics, including those most recently marketed.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drugs R D. 2015 Mar ;15(1):45-62. PMID: 25578944
Article Published Date : Feb 28, 2015
Study Type : Human: Case Report, Review
Additional Links
Diseases : Neuroleptic Malignant Syndrome
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs
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Cannabidiol acts in the dorsal striatum to improve haloperidol-induced catalepsy.Apr 26, 2016

Pubmed Data : Behav Brain Res. 2016 Apr 27 ;309:22-28. Epub 2016 Apr 27. PMID: 27131780
Article Published Date : Apr 26, 2016
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Antipsychotic Drugs
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Haloperidol and clozapine may induce oxidative stress in brain and liver, respectively, consistent with the documented adverse effects of these agents.Mar 29, 2015

Pubmed Data : Neurosci Lett. 2015 Mar 30 ;591:36-40. Epub 2015 Feb 13. PMID: 25684243
Article Published Date : Mar 29, 2015
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress, Lipid Peroxidation, Oxidative Stress
Additional Keywords : Haloperidol, Increased Risk
Problem Substances : Antipsychotic Drugs, Clozapine
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Prenatally drug treated rat offspring displayed post natal developmental delay till postnatal day 70, and these young adult rats displayed cognitive impairment.Apr 30, 2015

Pubmed Data : Int J Dev Neurosci. 2015 May ;42:59-67. Epub 2015 Feb 23. PMID: 25720310
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures
Additional Keywords : Fetal Neurotoxicity
Problem Substances : Antipsychotic Drugs, Quetiapine
Adverse Pharmacological Actions : Neurotoxic
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Transcranial low-level infrared laser irradiation ameliorates depression induced by reserpine.Oct 31, 2016

Pubmed Data : Lasers Med Sci. 2016 Nov ;31(8):1651-1656. Epub 2016 Jul 20. PMID: 27437987
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Risk Reduction
Problem Substances : Antipsychotic Drugs
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Antipsychotic adverse effects are diverse and frequently experienced, but are not often systematically assessed.Mar 31, 2015

Pubmed Data : J Psychopharmacol. 2015 Apr ;29(4):353-62. Epub 2014 Dec 16. PMID: 25516373
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Diseases : Dyslipidemias, Metabolic Diseases
Additional Keywords : Adverse Events
Problem Substances : Antipsychotic Drugs
Adverse Pharmacological Actions : Cardiotoxic
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Antipsychotic medication use in nursing home residents was found to have variable efficacy when used off-label with an increased risk of many adverse events.May 31, 2015

Pubmed Data : Health Policy. 2015 Jun ;119(6):802-813. Epub 2015 Feb 28. PMID: 25791166
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Additional Keywords : Elderly, Increased Risk
Problem Substances : Antipsychotic Drugs
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Berberine could be used as a potential adjuvant to prevent dyslipidemia and obesity caused by the use of second-generation antipsychotic medication.Nov 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Nov 9 ;17(11). Epub 2016 Aug 9. PMID: 27834848
Article Published Date : Nov 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Dyslipidemias, Obesity
Pharmacological Actions : Prophylactic Agents
Problem Substances : Antipsychotic Drugs, Olanzapine
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Curcumin accelerates the release of exosomes containing cholesterol from cells with impaired intracellular cholesterol trafficking due to antipsychotic treatment.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(10):e0141829. Epub 2015 Oct 30. PMID: 26517556
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Cytoprotective
Problem Substances : Antipsychotic Drugs
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Drugs with anticholinergic and antiadrenergic effects such as tricyclic antidepressants may cause dry mouth and related complications such as candidiasis and other oral infections.Dec 31, 2013

Pubmed Data : Int J Psychiatry Med. 2014 ;48(3):185-97. PMID: 25492713
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Diseases : Candidiasis, Dental Diseases, Mouth Dryness
Additional Keywords : Increased Risk
Problem Substances : Antidepressants, Antipsychotic Drugs, Beta Blockers
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Extensive impact of non-antibiotic drugs on human gut bacteria.Mar 18, 2018

Pubmed Data : Nature. 2018 Mar 19. Epub 2018 Mar 19. PMID: 29555994
Article Published Date : Mar 18, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Dysbiosis, Infection: Antibiotic Resistant
Additional Keywords : Risk Factors
Problem Substances : Antipsychotic Drugs
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Second generation antipsychotic drugs could induce mitochondrial alterations that could increase the risk of metabolic syndrome.Feb 11, 2018

Pubmed Data : Eur Neuropsychopharmacol. 2018 Feb 12. Epub 2018 Feb 12. PMID: 29449054
Article Published Date : Feb 11, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Electron Transport Chain Deficiencies: Mitochondrial, Metabolic Syndrome X, Mitochondrial Dysfunction
Problem Substances : Antipsychotic Drugs
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The review of current observational evidence suggests that exposure to first generation and second generation AP drugs are associated with an increased risk of pneumonia.May 26, 2015

Pubmed Data : Pharmacoepidemiol Drug Saf. 2015 May 27. Epub 2015 May 27. PMID: 26017021
Article Published Date : May 26, 2015
Study Type : Review
Additional Links
Diseases : Pneumonia
Additional Keywords : Increased Risk
Problem Substances : Antipsychotic Drugs

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