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Aromatase Inhibitor Drugs
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Additional Topics Details for this Page
Article Count
- 21
Cumulative Knowledge
- 360
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Related Topics
The Following are Sub-Topics of Aromatase Inhibitor Drugs
Arimidex
Letrozole (trade name Femera)
Exemestane
What is Cumulative Knowledge?
Cumulative Knowledge
is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.
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Quick Summary: Current access displays 2 out of 31 associated Diseases
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Cumulative Knowledge
Article Count
Focus Articles
Breast Cancer
172
10
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Drug-Induced Toxicity
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Quick Summary: Current access displays 2 out of 6 associated Adverse Pharmacological Actions
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Carcinogenic
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View the Evidence: Problem Substances
Two year treatment with Tamoxifen and Arimidex result in a number of side effects which reduce quality of life.
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2006 Dec;100(3):273-84. Epub 2006 Jun 21. PMID:
16944295
Article Published Date
: Dec 01, 2006
Study Type
: Meta Analysis
Additional Links
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
Additional Keywords
:
Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances
:
Arimidex : CK(122) : AC(12)
,
Tamoxifen : CK(319) : AC(39)
A case of anastrozole-induced pulmonary emboli has been reported.
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2006 Oct;99(3):249-55. Epub 2006 Jun 3. PMID:
16752073
Article Published Date
: Oct 01, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer : CK(2354) : AC(621)
,
Pulmonary Embolism : CK(40) : AC(4)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
Problem Substances
:
Arimidex : CK(122) : AC(12)
,
Aromatase Inhibitor Drugs : CK(360) : AC(21)
Adjuvant treatment with aromatase inhibitors in breast cancer result in higher rates of hot flushes, musculoskeletal complaints, osteoporosis and fractures.
Click here to read the entire abstract
Pubmed Data
: Curr Med Res Opin. 2006 Aug;22(8):1609-21. PMID:
16870085
Article Published Date
: Aug 01, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Bone Fractures : CK(1610) : AC(69)
,
Breast Cancer : CK(2354) : AC(621)
,
Drug-Induced Toxicity : CK(560) : AC(78)
,
Hot Flash : CK(203) : AC(19)
,
Musculoskeletal Complaints : CK(13) : AC(2)
,
Pain: Musculoskeletal : CK(30) : AC(3)
Additional Keywords
:
Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances
:
Arimidex : CK(122) : AC(12)
,
Aromatase Inhibitor Drugs : CK(360) : AC(21)
Anastrozole has been reported to cause skin eruptions as a potential side effects.
Click here to read the entire abstract
Pubmed Data
: Dermatol Online J. 2009;15(7):14. Epub 2009 Jul 15. PMID:
19903442
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Skin Diseases : CK(46) : AC(9)
Problem Substances
:
Arimidex : CK(122) : AC(12)
,
Aromatase Inhibitor Drugs : CK(360) : AC(21)
Anastrozole use has been associated with sclerosing glomerulonephritis in a patient with breast cancer.
Click here to read the entire abstract
Pubmed Data
: Oncology. 2007;73(5-6):415-8. Epub 2008 Jun 2. PMID:
18515982
Article Published Date
: Jan 01, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer : CK(2354) : AC(621)
,
Glomerulonephritis : CK(41) : AC(9)
Problem Substances
:
Arimidex : CK(122) : AC(12)
Arimidex (anastrozole) treatment in men with breast cancer is associated with toxicity in 37.5% of the group studied.
Click here to read the entire abstract
Pubmed Data
: Curr Oncol. 2010 Oct;17(5):17-21. PMID:
20975874
Article Published Date
: Oct 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer: Male : CK(11) : AC(1)
Problem Substances
:
Arimidex : CK(122) : AC(12)
,
Aromatase Inhibitor Drugs : CK(360) : AC(21)
Arimidex therapy contributes in the decline of bone mineral density in early breast cancer patients.
Click here to read the entire abstract
Pubmed Data
: Bratisl Lek Listy. 2010;111(1):27-32. PMID:
20429308
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer : CK(2354) : AC(621)
,
Osteoporosis : CK(1171) : AC(205)
Additional Keywords
:
Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances
:
Arimidex : CK(122) : AC(12)
,
Aromatase Inhibitor Drugs : CK(360) : AC(21)
,
Letrozole (trade name Femera) : CK(84) : AC(10)
Aromatase inhibitors can induce an arthralgia syndrome.
Click here to read the entire abstract
Pubmed Data
: J Clin Oncol. 2008 Jul 1;26(19):3147-52. Epub 2008 May 12. PMID:
18474874
Article Published Date
: Jul 01, 2008
Study Type
: Human Study
Additional Links
Diseases
:
Arthralgia : CK(23) : AC(3)
,
Breast Cancer : CK(2354) : AC(621)
,
Drug-Induced Toxicity : CK(560) : AC(78)
,
Musculoskeletal Abnormalities : CK(40) : AC(4)
,
Rheumatic Diseases : CK(20) : AC(2)
Additional Keywords
:
Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances
:
Aromatase Inhibitor Drugs : CK(360) : AC(21)
Clinically relevant musculoskeletal symptoms develop in women treated with aromatase inhibitors, leading to treatment discontinuation in a substantial percentage of these patients.
Click here to read the entire abstract
Pubmed Data
: Cancer. 2010 Sep 15;116(18):4360-7. PMID:
20549827
Article Published Date
: Sep 15, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
,
Musculoskeletal Abnormalities : CK(40) : AC(4)
Problem Substances
:
Exemestane : CK(30) : AC(3)
,
Letrozole (trade name Femera) : CK(84) : AC(10)
Letrozole decreases estrogen levels at 12 months but not 24 months, reduces bone density, does not reduce mammographic breast density at 12 months and increases IGF-1 (a known carcinogen) at 12 and 24 months in
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2010 Apr;120(2):427-35. Epub 2009 Dec 6. PMID:
19967558
Article Published Date
: Apr 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer : CK(2354) : AC(621)
,
Insulin-like Growth Factor (IGF): Elevated : CK(33) : AC(6)
Problem Substances
:
Aromatase Inhibitor Drugs : CK(360) : AC(21)
,
Letrozole (trade name Femera) : CK(84) : AC(10)
Adverse Pharmacological Actions
:
Carcinogenic : CK(912) : AC(117)
Musculoskeletal complaints are exceedingly common (71.5%) in those receiving long-term (6 months or longer) aromatase inhibitor therapy.
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2010 Feb;120(1):127-34. Epub 2009 Dec 25. PMID:
20035381
Article Published Date
: Feb 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Arthralgia : CK(23) : AC(3)
,
Arthritis : CK(1430) : AC(218)
,
Breast Cancer : CK(2354) : AC(621)
,
Drug-Induced Toxicity : CK(560) : AC(78)
,
Musculoskeletal Abnormalities : CK(40) : AC(4)
,
Myalgias : CK(105) : AC(14)
,
Polymyalgia Rheumatica : CK(63) : AC(7)
,
Tendinitis : CK(1433) : AC(7)
Problem Substances
:
Arimidex : CK(122) : AC(12)
,
Aromatase Inhibitor Drugs : CK(360) : AC(21)
,
Letrozole (trade name Femera) : CK(84) : AC(10)
Musculoskeletal pains in breast cancer patients under third generation AIs can be severe, debilitating and are associated with tenosynovial and joint changes.
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2007 Jul;104(1):87-91. Epub 2006 Oct 24. PMID:
17061044
Article Published Date
: Jul 01, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Breast Cancer: Recovery : CK(110) : AC(11)
,
Musculoskeletal Abnormalities : CK(40) : AC(4)
Problem Substances
:
Aromatase Inhibitor Drugs : CK(360) : AC(21)
,
Exemestane : CK(30) : AC(3)
,
Letrozole (trade name Femera) : CK(84) : AC(10)
Peripubertal aromatase inhibition in male rats has adverse long-term effects on bone strength and growth and induces prostatic hyperplasia.
Click here to read the entire abstract
Pubmed Data
: J Endocrinol. 2010 Oct;207(1):27-34. Epub 2010 Jul 30. PMID:
20675302
Article Published Date
: Oct 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Bone Diseases : CK(15) : AC(4)
,
Children: Impaired Growth : CK(30) : AC(3)
,
Drug-Induced Toxicity : CK(560) : AC(78)
,
Prostatic Hyperplasia: Benign : CK(202) : AC(46)
Problem Substances
:
Aromatase Inhibitor Drugs : CK(360) : AC(21)
,
Letrozole (trade name Femera) : CK(84) : AC(10)
Adverse Pharmacological Actions
:
Endocrine Disruptor : CK(478) : AC(81)
Health Guide: Breast Cancer
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