Artificial Sweeteners

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68 Diseases Researched for Artificial Sweeteners
11 Adverse Pharmacological Actions Researched for Artificial Sweeteners
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View the Evidence:
76 Abstracts with Artificial Sweeteners Research

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Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Study Type : Human Study
Additional Links
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Pubmed Data : Nature. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25231862
Study Type : Animal Study, Human Study
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Pubmed Data : J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194
Study Type : Human Study
Additional Links
Diseases : Brain Cancer
Problem Substances : Aspartame
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Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Study Type : Human Study
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Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267
Study Type : Human Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : J Toxicol Environ Health A. 2015 ;78(16):1029-32. Epub 2015 Aug 12. PMID: 26267522
Study Type : Human Study
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Pubmed Data : Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. PMID: 16679819
Study Type : Human Study
Additional Links
Problem Substances : Sodium Cyclamate
Adverse Pharmacological Actions : Irritant
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Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524
Study Type : Human Study
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Pubmed Data : Diabetes Care. 2009 Apr;32(4):688-94. Epub 2009 Jan 16. PMID: 19151203
Study Type : Human Study
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Pubmed Data : Clin Exp Rheumatol. 2012 Jul 4. Epub 2012 Jul 4. PMID: 22766026
Study Type : Human Study
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Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Study Type : Human Study
Additional Links
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Pubmed Data : Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Sep 9. Epub 2016 Sep 9. PMID: 27612000
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
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Pubmed Data : Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081
Study Type : Human: Case Report
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Pubmed Data : Horm Metab Res. 1987 Jul;19(7):285-9. PMID: 2887503
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium
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Pubmed Data : Horm Metab Res. 1987 Jun;19(6):233-8. PMID: 2887500
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium
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Pubmed Data : Endocrinol Nutr. 2015 Mar ;62(3):114-22. Epub 2015 Feb 11. PMID: 25681123
Study Type : Animal Study
Additional Links
Additional Keywords : Cytokines
Problem Substances : Aspartame
Adverse Pharmacological Actions : Immunoreactive, Oxidant
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Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619
Study Type : Animal Study
Additional Links
Diseases : Cancers: All
Problem Substances : Aspartame
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Pubmed Data : Int J Immunopathol Pharmacol. 2015 Jun ;28(2):247-55. Epub 2015 May 26. PMID: 26015492
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Hepatotoxic
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Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance, Neurotoxic
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Pubmed Data : Life Sci. 1998;63(5):337-49. PMID: 9714421
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
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Pubmed Data : Nutr Metab (Lond). 2012 Jun 14 ;9(1):58. Epub 2012 Jun 14. PMID: 22697049
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Diabetogenic, Endocrine Disruptor: Insulin Resistance
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Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(10):e109841. Epub 2014 Oct 14. PMID: 25313461
Study Type : Animal Study
Additional Links
Additional Keywords : Increased Risk, Microbiota
Problem Substances : Aspartame
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Pubmed Data : J Chem Neuroanat. 2016 Aug 24 ;78:42-56. Epub 2016 Aug 24. PMID: 27565676
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
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Pubmed Data : Food Chem Toxicol. 2008 Jun;46(6):2074-9. Epub 2008 Feb 8. PMID: 18343556
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2006 Mar;114(3):379-85. PMID: 16507461
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : Food Chem Toxicol. 2007 Dec;45(12):2397-401. Epub 2007 Jun 16. PMID: 17673349
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
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Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247507
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
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Pubmed Data : Cell Biol Toxicol. 2002;18(1):43-50. PMID: 11991085
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Formate
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Pubmed Data : Ann N Y Acad Sci. 2006 Sep;1076:559-77. PMID: 17119233
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
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Pubmed Data : Arch Oral Biol. 2013 Sep ;58(9):1116-22. Epub 2013 Apr 28. PMID: 23631998
Study Type : Animal Study
Additional Links
Diseases : Dental Caries
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Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2007 ;2(8):e698. Epub 2007 Aug 1. PMID: 17668074
Study Type : Animal Study
Additional Links
Problem Substances : Saccharin
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2007 Sep;115(9):1293-7. PMID: 17805418
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : Food Chem Toxicol. 2011 Jun ;49(6):1203-7. Epub 2011 Mar 3. PMID: 21376768
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Glutathione Down-Regulation, Hepatotoxic, Oxidant
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Pubmed Data : Nutrition. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27189909
Study Type : Animal Study
Additional Links
Problem Substances : Artificial Sweeteners, Saccharin
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Pubmed Data : Ultrastruct Pathol. 2014 May ;38(3):224-36. Epub 2014 Mar 31. PMID: 24684500
Study Type : Animal Study
Additional Links
Substances : Anise
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Essential Oils
Problem Substances : Aspartame
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2013 Jun 19 ;10(1):44. Epub 2013 Jun 19. PMID: 23783067
Study Type : Transgenic Animal Study
Additional Links
Diseases : Prediabetes
Adverse Pharmacological Actions : Diabetogenic
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Pubmed Data : Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID: 23088901
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Saccharin
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Pubmed Data : Int J Occup Environ Health. 2016 Jan ;22(1):7-17. Epub 2016 Jan 29. PMID: 27078173
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : Food Chem Toxicol. 1990 Jun;28(6):449-55. PMID: 2210518
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S71-89. PMID: 10882819
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Cell Metab. 2016 Jul 12 ;24(1):75-90. PMID: 27411010
Study Type : Animal Study
Additional Links
Diseases : Eating Disorders
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S53-69. PMID: 10882818
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Chemosphere. 2012 Jan ;86(1):50-5. Epub 2011 Sep 28. PMID: 21955350
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : J Toxicol Environ Health A. 2008;71(21):1415-29. PMID: 18800291
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biosci. 2014 Dec ;39(5):859-66. PMID: 25431414
Study Type : Animal Study
Additional Links
Additional Keywords : Increased Risk
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
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Pubmed Data : Environ Sci Technol. 2014 Dec 2 ;48(23):13668-74. Epub 2014 Nov 14. PMID: 25365516
Study Type : Environmental
Additional Links
Additional Keywords : Environmental Pollutant
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Pubmed Data : Proc Natl Acad Sci U S A. 2007 Sep 18 ;104(38):15075-80. Epub 2007 Aug 27. PMID: 17724332
Study Type : Animal Study
Additional Links
Additional Keywords : Cephalic Phase Effect
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Pubmed Data : Int J Occup Environ Health. 2010 Jan-Mar;16(1):89-96. PMID: 20166324
Study Type : Commentary
Additional Links
Problem Substances : Acesulfame potassium
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Pubmed Data : Food Chem Toxicol. 1997 Dec;35(12):1177-9. PMID: 9449223
Study Type : In Vitro Study
Additional Links
Problem Substances : Acesulfame potassium
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Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Study Type : In Vitro Study
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Pubmed Data : Med Hypotheses. 2010 Mar;74(3):493-6. Epub 2009 Nov 5. PMID: 19896282
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
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Pubmed Data : Dermatitis. 2008 May-Jun;19(3):E10-1. PMID: 18627677
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
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Pubmed Data : Eur J Clin Nutr. 2008 Apr;62(4):451-62. Epub 2007 Aug 8. PMID: 17684524
Study Type : Review
Additional Links
Problem Substances : Aspartame
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Pubmed Data : Pharmacol Res. 2006 Jan;53(1):1-5. Epub 2005 Aug 29. PMID: 16129618
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2016 Jul ;23(4):503-6. Epub 2015 Jun 15. PMID: 27298583
Study Type : In Vitro Study
Additional Links
Diseases : Cervical Cancer
Additional Keywords : Disease Progression, Risk Factors
Problem Substances : Aspartame
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Pubmed Data : Drug Chem Toxicol. 2008;31(4):447-57. PMID: 18850355
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
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Pubmed Data : Int J Occup Environ Health. 2007 Oct-Dec;13(4):446-8. PMID: 18085058
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
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Pubmed Data : Rev Endocr Metab Disord. 2016 Jul 7. Epub 2016 Jul 7. PMID: 27387506
Study Type : Review
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
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Pubmed Data : J Pharmacol Sci. 2003 Jan;91(1):83-6. PMID: 12686735
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Methanol
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Pubmed Data : Can J Gastroenterol. 2011 Sep ;25(9):511. PMID: 21912763
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
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Pubmed Data : Mol Cells. 2011 May ;31(5):461-70. Epub 2011 Apr 21. PMID: 21533907
Study Type : In Vitro Study
Additional Links
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mayo Clin Proc. 2015 Mar ;90(3):372-81. Epub 2015 Jan 29. PMID: 25639270
Study Type : Review
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Pubmed Data : Drug Chem Toxicol. 2015 ;38(3):318-27. Epub 2014 Oct 15. PMID: 25317478
Study Type : In Vitro Study
Additional Links
Additional Keywords : Increased Risk
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Pubmed Data : World J Gastroenterol. 2012 Apr 21 ;18(15):1708-22. PMID: 22553395
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
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Pubmed Data : Environ Sci Technol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21879743
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Environ Sci Technol. 2011 Jan 14. [Epub ahead of print]. PMID: 21235203
Study Type : In Vitro Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Headache. 2006 Sep;46(8):1303-4. PMID: 16942478
Study Type : Commentary
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Physiol Behav. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090230
Study Type : Bacterial
Additional Links
Additional Keywords : Microbiota, Risk Factors
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Pubmed Data : Cell Signal. 1998 Nov;10(10):727-33. PMID: 9884024
Study Type : In Vitro Study
Additional Links
Diseases : Hyperinsulinism
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Pubmed Data : Biomarkers. 2006 Jan-Feb;11(1):14-27. PMID: 16484134
Study Type : Commentary
Additional Links
Problem Substances : Aspartame, Benzene
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Pubmed Data : Nicotine Tob Res. 2016 May 23. Epub 2016 May 23. PMID: 27217475
Study Type : In Vitro Study
Additional Links
Additional Keywords : Risk Factors
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Pubmed Data : Folia Neuropathol. 2013 ;51(1):10-7. PMID: 23553132
Study Type : Review
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896
Study Type : In Vitro Study

Artificial Sweeteners Related Articles

Written by Sayer Ji, Founder
A newly published study is destined to reignite the decades old controversy about aspartame's safety, or lack thereof. Aspartame converts to formaldehyde and formic acid, which are highly toxic to the body, but the nervous system in particular.
Written by Anne Gordon, RN
Will aspartame in our milk be the new attractive 'diet' drink? The latest debate with letting you know what is in the food consumed is designed to make milk the new attractive 'diet' drink, along with many milk products.
Written by Sayer Ji, Founder
Increasingly, it is hard to find honey being used in foods or as a sweetener. Instead, sugar and corn-derived high fructose corn syrup has displaced it. But honey is vastly different than sugar.
Written by Sayer Ji, Founder
A groundbreaking new study reveals that non-caloric artificial sweeteners (NAS) drive obesity- and diabetes-related changes in both mice and humans.
The FDA claims aspartame is safe. Researchers claim it causes memory loss, mood changes, and depression. Who are you going to believe?
Despite warnings about the risks of chemicals in diet sodas, many people still rely on their daily Coke Zero. They take the risk because their greater concern is weight control. The sad irony is that diet sodas may actually be adding inches to their waistlines.
Written by Vic Shayne, Ph.D.
Sometimes going gluten free is just not enough to reduce symptoms of bloating and other functional bowel complaints, including IBS. Could there be more to the picture than previously believed? Enter the acronym FODMAPs, as it may provide a crucial missing link in solving the problem once and for all...
Written by Sayer Ji, Founder
A new study published this month in the journal Appetite revealed that when rats were given the synthetic sweeteners saccharin and aspartame, compared to sucrose (table sugar), they gained more weight even at similar total caloric intake levels
Avoid these sugar substitutes for breast cancer healing, prevention and a healthy, chemical-free lifestyle.
Written by Anne Gordon, RN
You’ve heard a lot about aspartame by now, the synthetic sweetener found in many diet soft drinks, thousands of foods and supplements. But when you realize that aspartame is the excrement of GM bacteria (E Coli bacteria)….it makes a controversial product seem less healthy.
Written by Gary Null, PhD
What are some natural methods to help curb the symptoms of depression and also address the fundamental causes of the condition?
Written by Sayer Ji, Founder
Is Splenda really a food, or a highly toxic chemical?
Written by Sayer Ji, Founder
So, you are looking to lose a few pounds, or keep them off. What better way to accomplish this feat than to eliminate both empty sugar calories and synthetic sweeteners, which studies show can generate excessive cravings for sweets and actually increase weight gain.
Written by Sayer Ji, Founder
Sugar and artificial sweeteners are so accessible, affordable and socially sanctioned, that few consider their habitual consumption to be a problem on the scale of say, addiction to cocaine. But if recent research is correct, their addictive potential could be even worse.
Written by Sayer Ji, Founder
A concerning new study finds that most of the breast milk samples tested contained artificial sweeteners. Why has this never been discovered until now and what are the implications to our most vulnerable populations?
Written by Sayer Ji, Founder
Pushed globally as a beneficial to dieters since its approval in 1981, accumulating research indicates that aspartame may actually damage the brain and cause cancer, to name but a few of a wide range of adverse health effects consumers risk by using this 'no-calorie' sugar alternative.
Written by Sayer Ji, Founder
Promoted for decades as a "safe" sugar alternative, presumably to prevent or reduce symptoms of diabetes, Splenda (sucralose) has been found to have diabetes-promoting effects in human subjects.

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