Artificial Sweeteners

Artificial Sweeteners

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View the Evidence: Problem Substances

Artificial sweetener consumption is associated with urinary tract tumors.

Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Urinary Tract Cancer : CK(22) : AC(4)
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

Aspartame may be linked to increasing brain cancer rates.

Pubmed Data : J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194
Article Published Date : Nov 01, 1996
Study Type : Human Study
Additional Links
Diseases : Brain Cancer : CK(231) : AC(88)
Problem Substances : Aspartame : CK(103) : AC(30)

Consumption of≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.

Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Article Published Date : Sep 30, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Failure : CK(668) : AC(41)
Problem Substances : Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2), Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

In men,≥1 daily serving of diet soda increased risks of NHL and multiple myleoma.

Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267
Article Published Date : Oct 23, 2012
Study Type : Human Study
Additional Links
Diseases : Multiple Myeloma : CK(156) : AC(53), Non-Hodgkin Lymphoma : CK(525) : AC(67)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Sodium lauryl sulfate may have irritant properties in the human face.

Pubmed Data : Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. PMID: 16679819
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Problem Substances : Sodium Cyclamate : CK(15) : AC(4)
Adverse Pharmacological Actions : Irritant : CK(49) : AC(9)

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load.

Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524
Article Published Date : Apr 29, 2013
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Sucralose : CK(15) : AC(10)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

The consumption of diet soda at least daily was associated with significantly greater risks of select incident metabolic syndrome components and type 2 diabetes.

Pubmed Data : Diabetes Care. 2009 Apr;32(4):688-94. Epub 2009 Jan 16. PMID: 19151203
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122)
Problem Substances : Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2)

The dietary additive excitotoxins MSG and aspartame contribute to fibromyalgia symptoms.

Pubmed Data : Clin Exp Rheumatol. 2012 Jul 4. Epub 2012 Jul 4. PMID: 22766026
Article Published Date : Jul 03, 2012
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia : CK(537) : AC(57)
Therapeutic Actions : Dietary Modification: Glutamic and Aspartic Acid Reduced (G.A.R.D) : CK(10) : AC(1)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)

The elimination of MSG, Aspartame and other excitotoxins from the diets of patients with fibromyalgia is a successful treatment option.

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Article Published Date : Jun 01, 2001
Study Type : Human Study
Additional Links
Diseases : Excitotoxicity : CK(56) : AC(33), Fibromyalgia : CK(537) : AC(57)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)

Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water has been reported.

Pubmed Data : Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081
Article Published Date : Mar 30, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Acidosis : CK(50) : AC(10), Metabolic Acidosis : CK(52) : AC(9)
Additional Keywords : False Diabetic Ketoacidosis
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2), Aspartame : CK(103) : AC(30), Sodium Cyclamate : CK(15) : AC(4)

Acesulfame K acts directly on the pancreatic islets and potentiates glucose-induced insulin release.

Pubmed Data : Horm Metab Res. 1987 Jul;19(7):285-9. PMID: 2887503
Article Published Date : Jul 01, 1987
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism : CK(1182) : AC(41)
Problem Substances : Acesulfame potassium : CK(22) : AC(8)

Acesulfame stimulates insulin secretion.

Pubmed Data : Horm Metab Res. 1987 Jun;19(6):233-8. PMID: 2887500
Article Published Date : Jun 01, 1987
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism : CK(1182) : AC(41)
Problem Substances : Acesulfame potassium : CK(22) : AC(8)

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.

Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Liver Cancer : CK(1641) : AC(266), Lung Cancer : CK(496) : AC(198), Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Aspartame affects genes associated with cancer and may increase gene expression in organs with a high proliferation rate.

Pubmed Data : In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869)
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males.

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Neurotoxic : CK(1076) : AC(179)

Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.

Pubmed Data : Life Sci. 1998;63(5):337-49. PMID: 9714421
Article Published Date : Jan 01, 1998
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame exposure may promote hyperglycemia and insulin intolerance. MSG may interact with aspartame to further impair glucose homeostasis.

Pubmed Data : Nutr Metab (Lond). 2012 Jun 14 ;9(1):58. Epub 2012 Jun 14. PMID: 22697049
Article Published Date : Jun 14, 2012
Study Type : Animal Study
Additional Links
Diseases : Hyperglycemia : CK(2892) : AC(59), Insulin: Elevated : CK(186) : AC(41), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Aspartame induces brain oxidative stress and vascular congestion in the animal model.

Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Article Published Date : Mar 02, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress : CK(2) : AC(1), Brain: Vascular Congestion : CK(2) : AC(1)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

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