Artificial Sweeteners

Artificial Sweeteners

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View the Evidence: Problem Substances

Artificial sweetener consumption is associated with urinary tract tumors.

Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Urinary Tract Cancer : CK(22) : AC(4)
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

Aspartame may be linked to increasing brain cancer rates.

Pubmed Data : J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194
Article Published Date : Nov 01, 1996
Study Type : Human Study
Additional Links
Diseases : Brain Cancer : CK(231) : AC(88)
Problem Substances : Aspartame : CK(103) : AC(30)

Consumption of≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.

Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Article Published Date : Sep 30, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Failure : CK(668) : AC(41)
Problem Substances : Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2), Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

In men,≥1 daily serving of diet soda increased risks of NHL and multiple myleoma.

Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267
Article Published Date : Oct 23, 2012
Study Type : Human Study
Additional Links
Diseases : Multiple Myeloma : CK(156) : AC(53), Non-Hodgkin Lymphoma : CK(525) : AC(67)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Sodium lauryl sulfate may have irritant properties in the human face.

Pubmed Data : Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. PMID: 16679819
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Problem Substances : Sodium Cyclamate : CK(15) : AC(4)
Adverse Pharmacological Actions : Irritant : CK(49) : AC(9)

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load.

Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524
Article Published Date : Apr 29, 2013
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Sucralose : CK(15) : AC(10)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

The consumption of diet soda at least daily was associated with significantly greater risks of select incident metabolic syndrome components and type 2 diabetes.

Pubmed Data : Diabetes Care. 2009 Apr;32(4):688-94. Epub 2009 Jan 16. PMID: 19151203
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122)
Problem Substances : Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2)

The dietary additive excitotoxins MSG and aspartame contribute to fibromyalgia symptoms.

Pubmed Data : Clin Exp Rheumatol. 2012 Jul 4. Epub 2012 Jul 4. PMID: 22766026
Article Published Date : Jul 03, 2012
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia : CK(537) : AC(57)
Therapeutic Actions : Dietary Modification: Glutamic and Aspartic Acid Reduced (G.A.R.D) : CK(10) : AC(1)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)

The elimination of MSG, Aspartame and other excitotoxins from the diets of patients with fibromyalgia is a successful treatment option.

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Article Published Date : Jun 01, 2001
Study Type : Human Study
Additional Links
Diseases : Excitotoxicity : CK(56) : AC(33), Fibromyalgia : CK(537) : AC(57)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)

Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water has been reported.

Pubmed Data : Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081
Article Published Date : Mar 30, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Acidosis : CK(50) : AC(10), Metabolic Acidosis : CK(52) : AC(9)
Additional Keywords : False Diabetic Ketoacidosis
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2), Aspartame : CK(103) : AC(30), Sodium Cyclamate : CK(15) : AC(4)

Acesulfame K acts directly on the pancreatic islets and potentiates glucose-induced insulin release.

Pubmed Data : Horm Metab Res. 1987 Jul;19(7):285-9. PMID: 2887503
Article Published Date : Jul 01, 1987
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism : CK(1182) : AC(41)
Problem Substances : Acesulfame potassium : CK(22) : AC(8)

Acesulfame stimulates insulin secretion.

Pubmed Data : Horm Metab Res. 1987 Jun;19(6):233-8. PMID: 2887500
Article Published Date : Jun 01, 1987
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism : CK(1182) : AC(41)
Problem Substances : Acesulfame potassium : CK(22) : AC(8)

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.

Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Liver Cancer : CK(1641) : AC(266), Lung Cancer : CK(496) : AC(198), Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Aspartame affects genes associated with cancer and may increase gene expression in organs with a high proliferation rate.

Pubmed Data : In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869)
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males.

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Neurotoxic : CK(1076) : AC(179)

Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.

Pubmed Data : Life Sci. 1998;63(5):337-49. PMID: 9714421
Article Published Date : Jan 01, 1998
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame exposure may promote hyperglycemia and insulin intolerance. MSG may interact with aspartame to further impair glucose homeostasis.

Pubmed Data : Nutr Metab (Lond). 2012 Jun 14 ;9(1):58. Epub 2012 Jun 14. PMID: 22697049
Article Published Date : Jun 14, 2012
Study Type : Animal Study
Additional Links
Diseases : Hyperglycemia : CK(2892) : AC(59), Insulin: Elevated : CK(186) : AC(41), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Aspartame induces brain oxidative stress and vascular congestion in the animal model.

Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Article Published Date : Mar 02, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress : CK(2) : AC(1), Brain: Vascular Congestion : CK(2) : AC(1)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Related Blogs

Study: Saccharin And Sugar Found More Addictive Than Cocaine
Written by Sayer Ji, Founder
Sugar and artificial sweeteners are so accessible, affordable and socially sanctioned, that few consider their habitual consumption to be a problem on the scale of say, addiction to cocaine. But if recent research is correct, their addictive potential could be even worse.
Avoiding FODMAPS, Because Gluten-Free Diets Are Not Enough
Written by Vic Shayne, Ph.D.
Sometimes going gluten free is just not enough to reduce symptoms of bloating and other functional bowel complaints, including IBS. Could there be more to the picture than previously believed? Enter the acronym FODMAPs, as it may provide a crucial missing link in solving the problem once and for all...
Aspartame: Safety Approved In 90 Nations, But Damages Brain
Written by Sayer Ji, Founder
A newly published study is destined to reignite the decades old controversy about aspartame's safety, or lack thereof. Aspartame converts to formaldehyde and formic acid, which are highly toxic to the body, but the nervous system in particular.

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