Aspartame

Aspartame

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View the Evidence: Problem Substances

Artificial sweetener consumption is associated with urinary tract tumors.

Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Urinary Tract Cancer : CK(22) : AC(4)
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

Aspartame may be linked to increasing brain cancer rates.

Pubmed Data : J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194
Article Published Date : Nov 01, 1996
Study Type : Human Study
Additional Links
Diseases : Brain Cancer : CK(231) : AC(88)
Problem Substances : Aspartame : CK(103) : AC(30)

Consumption of≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.

Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Article Published Date : Sep 30, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Failure : CK(668) : AC(41)
Problem Substances : Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2), Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

In men,≥1 daily serving of diet soda increased risks of NHL and multiple myleoma.

Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267
Article Published Date : Oct 24, 2012
Study Type : Human Study
Additional Links
Diseases : Multiple Myeloma : CK(156) : AC(53), Non-Hodgkin Lymphoma : CK(525) : AC(67)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

The dietary additive excitotoxins MSG and aspartame contribute to fibromyalgia symptoms.

Pubmed Data : Clin Exp Rheumatol. 2012 Jul 4. Epub 2012 Jul 4. PMID: 22766026
Article Published Date : Jul 04, 2012
Study Type : Human Study
Additional Links
Diseases : Fibromyalgia : CK(537) : AC(57)
Therapeutic Actions : Dietary Modification: Glutamic and Aspartic Acid Reduced (G.A.R.D) : CK(10) : AC(1)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)

The elimination of MSG, Aspartame and other excitotoxins from the diets of patients with fibromyalgia is a successful treatment option.

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Article Published Date : Jun 01, 2001
Study Type : Human Study
Additional Links
Diseases : Excitotoxicity : CK(56) : AC(33), Fibromyalgia : CK(537) : AC(57)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)

Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water has been reported.

Pubmed Data : Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081
Article Published Date : Mar 30, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Acidosis : CK(50) : AC(10), Metabolic Acidosis : CK(52) : AC(9)
Additional Keywords : False Diabetic Ketoacidosis
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2), Aspartame : CK(103) : AC(30), Sodium Cyclamate : CK(15) : AC(4)

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.

Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Liver Cancer : CK(1641) : AC(266), Lung Cancer : CK(496) : AC(198), Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Aspartame affects genes associated with cancer and may increase gene expression in organs with a high proliferation rate.

Pubmed Data : In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869)
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males.

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Neurotoxic : CK(1076) : AC(179)

Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.

Pubmed Data : Life Sci. 1998;63(5):337-49. PMID: 9714421
Article Published Date : Jan 01, 1998
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame exposure may promote hyperglycemia and insulin intolerance. MSG may interact with aspartame to further impair glucose homeostasis.

Pubmed Data : Nutr Metab (Lond). 2012 Jun 14 ;9(1):58. Epub 2012 Jun 14. PMID: 22697049
Article Published Date : Jun 14, 2012
Study Type : Animal Study
Additional Links
Diseases : Hyperglycemia : CK(2892) : AC(59), Insulin: Elevated : CK(186) : AC(41), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Aspartame : CK(103) : AC(30), Monosodium Glutamate (MSG) : CK(39) : AC(12)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Aspartame induces brain oxidative stress and vascular congestion in the animal model.

Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Article Published Date : Mar 02, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress : CK(2) : AC(1), Brain: Vascular Congestion : CK(2) : AC(1)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Aspartame intake corresponding to common doses results in signs of neurotoxicity in rats.

Pubmed Data : Food Chem Toxicol. 2008 Jun;46(6):2074-9. Epub 2008 Feb 8. PMID: 18343556
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Neurologic Disorders : CK(63) : AC(21)
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame is a multipotential carcinogenic agent even at doses well below the current acceptable daily intake.

Pubmed Data : Environ Health Perspect. 2006 Mar;114(3):379-85. PMID: 16507461
Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Leukemia : CK(670) : AC(258), Lymphoma : CK(209) : AC(69)
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame is associated with neurological dysfunction.

Pubmed Data : Food Chem Toxicol. 2007 Dec;45(12):2397-401. Epub 2007 Jun 16. PMID: 17673349
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame produces methanol as a metabolite, which can be converted into the cytotoxic chemicals formaledhyde and formate.

Pubmed Data : Cell Biol Toxicol. 2002;18(1):43-50. PMID: 11991085
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(103) : AC(30), Formaldehyde : CK(19) : AC(10), Formate : CK(2) : AC(1)

Aspatame is associated with the creation of numerous cancers in rats.

Pubmed Data : Ann N Y Acad Sci. 2006 Sep;1076:559-77. PMID: 17119233
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Bladder Cancer : CK(186) : AC(60), Leukemia : CK(670) : AC(258), Lymphoma : CK(209) : AC(69), Renal Cancer : CK(25) : AC(4), Schwannoma : CK(4) : AC(2)
Problem Substances : Aspartame : CK(103) : AC(30)

Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation.

Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Article Published Date : Sep 01, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation : CK(79) : AC(35), Excitotoxicity : CK(56) : AC(33), Lipid Peroxidation : CK(403) : AC(127)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Life-span exposure to low doses of aspartame beginning during prenatal life increases leukemia and lymphoma rates in rats.

Pubmed Data : Environ Health Perspect. 2007 Sep;115(9):1293-7. PMID: 17805418
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Leukemia : CK(670) : AC(258), Lymphoma : CK(209) : AC(69)
Problem Substances : Aspartame : CK(103) : AC(30)

Long term consumption of aspartame causes liver injury and oxidative stress in the rat liver.

Pubmed Data : Food Chem Toxicol. 2011 Jun ;49(6):1203-7. Epub 2011 Mar 3. PMID: 21376768
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Diseases : ALT: Elevated : CK(60) : AC(10), AST: Elevated : CK(26) : AC(4), Chemically-Induced Liver Damage : CK(475) : AC(175), Oxidative Stress : CK(1945) : AC(710)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Glutathione Down-Regulation : CK(4) : AC(2), Hepatotoxic : CK(283) : AC(80), Oxidant : CK(104) : AC(37)

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult rats, at similar total caloric intake levels.

Pubmed Data : Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID: 23088901
Article Published Date : Oct 19, 2012
Study Type : Animal Study
Additional Links
Diseases : Appetite Disorders : CK(105) : AC(13), Obesity : CK(1849) : AC(275), Overweight : CK(2176) : AC(342)
Problem Substances : Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30), Excitotoxicity : CK(56) : AC(33), Neurodevelopmental Disorders : CK(163) : AC(13)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Problem Substances : Aspartame : CK(103) : AC(30), Brilliant Blue FCF : CK(4) : AC(3), L-glutamic Acid : CK(11) : AC(2), Quinoline Yellow : CK(1) : AC(1)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Aspartame contains 11% methanol by weight, which converts to formaldehyde in organs other than the liver.

Pubmed Data : Med Hypotheses. 2010 Mar;74(3):493-6. Epub 2009 Nov 5. PMID: 19896282
Article Published Date : Mar 01, 2010
Study Type : Commentary
Additional Links
Problem Substances : Aspartame : CK(103) : AC(30)

Aspartame is broken down into formaldehyde in various tissues and may contribute to migraines.

Pubmed Data : Dermatitis. 2008 May-Jun;19(3):E10-1. PMID: 18627677
Article Published Date : May 01, 2008
Study Type : Commentary
Additional Links
Diseases : Migraine Disorders : CK(486) : AC(58)
Problem Substances : Aspartame : CK(103) : AC(30)

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