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Benzene

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Article Count - 22
Cumulative Knowledge - 130

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View the Evidence: Problem Substances

Benzene and Aspergillus exposures are associated with sick building syndrome.

Click here to read the entire abstract

Pubmed Data : Sci Total Environ. 2009 Sep 15;407(19):5223-8. Epub 2009 Jul 15. PMID: 19608217

Article Published Date : Sep 15, 2009

Study Type : Human Study

Additional Links

Diseases : Sick Building Syndrome : CK(10) : AC(1)

Problem Substances : Aspergillus : CK(10) : AC(1), Benzene : CK(130) : AC(22)

Benzene exposure at below 1 part per million (1 ppm) causes hematotoxicity in exposed workers.

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2010 Mar 19;184(1-2):86-93. Epub 2009 Dec 21. PMID: 20026094

Article Published Date : Mar 19, 2010

Study Type : Human Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Benzene : CK(130) : AC(22)

Benzene exposure in parts per billion has been shown to adversely effect DNA in a manner consisent with increased risk for lymphoma and leukemia.

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Pubmed Data : Chem Biol Interact. 2005 May 30;153-154:75-83. Epub 2005 Apr 1. PMID: 15935802

Article Published Date : May 30, 2005

Study Type : Human Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Leukemia : CK(670) : AC(258), Lymphoma : CK(209) : AC(69)

Problem Substances : Benzene : CK(130) : AC(22)

Benzene exposure is associated with hypertension, possibly due to disturbance of nitric oxide process.

Click here to read the entire abstract

Pubmed Data : Cardiovasc J Afr. 2007 Jul-Aug;18(4):264-5. PMID: 17940673

Article Published Date : Jul 01, 2007

Study Type : Human Study

Additional Links

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Hypertension : CK(2783) : AC(271)

Problem Substances : Benzene : CK(130) : AC(22)

Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9)

Benzene exposure is associated with leukemia-associated changes in the peripheral blood lymphocytes of workers.

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Pubmed Data : Carcinogenesis. 2011 Jan 7. Epub 2011 Jan 7. PMID: 21216845

Article Published Date : Jan 07, 2011

Study Type : Human Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)

Problem Substances : Benzene : CK(130) : AC(22)

Adverse Pharmacological Actions : Carcinogen : CK(59) : AC(11)

Benzene exposure near the US permissible limit is associated wtih sperm aneuploidy (chromosomal abnormality).

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Pubmed Data : Environ Health Perspect. 2010 Jan 6. Epub 2010 Jan 6. PMID: 20418200

Article Published Date : Jan 06, 2010

Study Type : Human Study

Additional Links

Diseases : Infertility: Male : CK(209) : AC(52), Sperm Quality: Low : CK(162) : AC(28)

Problem Substances : Benzene : CK(130) : AC(22)

Crude oil exposure has been linked to acute myelogenous leukemia and multiple myeloma, in part due to benzene.

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Pubmed Data : Cancer Causes Control. 2008 Feb;19(1):13-23. Epub 2007 Sep 29. PMID: 17906934

Article Published Date : Feb 01, 2008

Study Type : Human Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28), Multiple Myeloma : CK(156) : AC(53)

Problem Substances : Benzene : CK(130) : AC(22), Crude Oil/Petroleum : CK(273) : AC(34)

Exposure to toxic compounds from an oil spill is correlated with an increased risk of health effects among pregnant women.

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Pubmed Data : J Prev Med Public Health. 2009 Mar;42(2):96-103. PMID: 19349738

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Benzene : CK(130) : AC(22), Crude Oil/Petroleum : CK(273) : AC(34), Ethylbenzene : CK(10) : AC(1), Toluene : CK(20) : AC(6), Xylene : CK(18) : AC(5)

Exposure to various chemicals is associated with increased risk for myelodysplastic syndrome according to the WHO.

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Pubmed Data : Am J Hematol. 2011 Feb;86(2):163-169. PMID: 21264898

Article Published Date : Feb 01, 2011

Study Type : Human Study

Additional Links

Diseases : Myelodysplastic Syndrome : CK(198) : AC(18)

Problem Substances : Benzene : CK(130) : AC(22), Crude Oil/Petroleum : CK(273) : AC(34), Herbicide : CK(130) : AC(42), Pesticides : CK(699) : AC(70), Tobacco: Smoking : CK(125) : AC(12)

Offshore workers have a higher risk of acute myelogenous leukemia, probably due to benzene exposure.

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Pubmed Data : Tidsskr Nor Laegeforen. 2004 Oct 21;124(20):2627-9. PMID: 15534638

Article Published Date : Oct 21, 2004

Study Type : Human Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)

Problem Substances : Benzene : CK(130) : AC(22), Crude Oil/Petroleum : CK(273) : AC(34)

Pathological protein adducts are associated with benzene and benzene metabolite exposures.

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Pubmed Data : Chem Biol Interact. 2005 May 30;153-154:103-9. Epub 2005 Apr 9. PMID: 15935805

Article Published Date : May 30, 2005

Study Type : Human Study

Additional Links

Problem Substances : Benzene : CK(130) : AC(22), Benzene Metabolites : CK(15) : AC(6)

Workers exposed to petroleum products may have increased risk for certain leukemias, in part due to benzene exposure.

Click here to read the entire abstract

Pubmed Data : Occup Environ Med. 1997 Mar;54(3):152-66. PMID: 9155776

Article Published Date : Mar 01, 1997

Study Type : Human Study

Additional Links

Diseases : Chronic Myeloid Leukemia : CK(21) : AC(11), Leukemia : CK(670) : AC(258), Leukemia: Monocytic : CK(11) : AC(2)

Problem Substances : Benzene : CK(130) : AC(22), Crude Oil/Petroleum : CK(273) : AC(34)

Benzene and its metabolites are leukemogenic.

Click here to read the entire abstract

Pubmed Data : Leukemia. 2010 May;24(5):986-91. Epub 2010 Mar 25. PMID: 20339439

Article Published Date : May 01, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Chronic Myeloid Leukemia : CK(21) : AC(11), Leukemia : CK(670) : AC(258), Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)

Problem Substances : Benzene : CK(130) : AC(22), Benzene Metabolites : CK(15) : AC(6), Hydroquinone : CK(1) : AC(1)

Benzene exposure may occur through inhalation, ingestion and topical exposures.

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2010 Mar 19;184(1-2):58-66. Epub 2010 Jan 6. PMID: 20056112

Article Published Date : Mar 19, 2010

Study Type : Review

Additional Links

Problem Substances : Benzene : CK(130) : AC(22)

Benzene is a well-known carcinogen which appears to exert its deleterious effects through DNA damage.

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2010 Mar 19;184(1-2):269-72. Epub 2010 Jan 6. PMID: 20056111

Article Published Date : Mar 19, 2010

Study Type : Commentary

Additional Links

Diseases : Cancers: All : CK(9062) : AC(2869), DNA damage : CK(711) : AC(293)

Problem Substances : Benzene : CK(130) : AC(22), Benzene Metabolites : CK(15) : AC(6)

Benzene metabolites may contribute to mutagenesis by overriding apoptosis and attenuating DNA repair capacity.

Click here to read the entire abstract

Pubmed Data : Mol Pharmacol. 1999 May;55(5):894-901. PMID: 10220568

Article Published Date : May 01, 1999

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Oxidative Stress : CK(1945) : AC(710)

Problem Substances : Benzene : CK(130) : AC(22), Benzene Metabolites : CK(15) : AC(6)

Benzene metabolites oxidize DNA and induced programmed cell death.

Click here to read the entire abstract

Pubmed Data : Cancer Res. 1996 Nov 15;56(22):5172-8. PMID: 8912853

Article Published Date : Nov 15, 1996

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Benzene : CK(130) : AC(22), Benzene Metabolites : CK(15) : AC(6)

Crude mineral oil contains benzene as a natural constituent of approximately 0.1%.

Click here to read the entire abstract

Pubmed Data : Am J Ind Med. 1985;7(5-6):375-83. PMID: 4003400

Article Published Date : Jan 01, 1985

Study Type : Commentary

Additional Links

Problem Substances : Benzene : CK(130) : AC(22), Crude Oil/Petroleum : CK(273) : AC(34)

European and North American countries limit indoor occupational exposures to benzene between 1.63-3.25mg/m3 (0.5-1 ppm).

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2005 May 30;153-154:43-53. Epub 2005 Apr 18. PMID: 15935799

Article Published Date : May 30, 2005

Study Type : Review

Additional Links

Problem Substances : Benzene : CK(130) : AC(22)

Sodium or potassium benzoate with ascorbic acid has been shown to produce low levels of benzene in fruit-flavored soft drinks.

Click here to read the entire abstract

Pubmed Data : J AOAC Int. 1993 Nov-Dec;76(6):1213-9. PMID: 8286958

Article Published Date : Nov 01, 1993

Study Type : Commentary

Additional Links

Problem Substances : Benzene : CK(130) : AC(22), Benzene Metabolites : CK(15) : AC(6), Potassium benzoate : CK(1) : AC(1), Sodium Benzoate : CK(202) : AC(16)

Sunscreen significantly enhances the absorption of benzene through the skin.

Click here to read the entire abstract

Pubmed Data : J Toxicol Environ Health. 1997 Aug 8;51(5):447-62. PMID: 9233379

Article Published Date : Aug 08, 1997

Study Type : In Vitro Study

Additional Links

Diseases : Benzene Toxicity : CK(28) : AC(12)

Additional Keywords : Toxic Substance Synergy : CK(5) : AC(3)

Problem Substances : Benzene : CK(130) : AC(22), Sunscreen : CK(71) : AC(14)

The consumption of aspartame is associated with higher serum levels of a benzene metabolite associated with blood disorders and leukemia.

Click here to read the entire abstract

Pubmed Data : Biomarkers. 2006 Jan-Feb;11(1):14-27. PMID: 16484134

Article Published Date : Jan 01, 2006

Study Type : Commentary

Additional Links

Diseases : Hematologic Diseases : CK(32) : AC(5), Leukemia : CK(670) : AC(258)

Problem Substances : Aspartame : CK(103) : AC(30), Benzene : CK(130) : AC(22)

Health Guide: Chemical Exposures

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