Bisphosphonates

Bisphosphonates

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The Following are Sub-Topics of Bisphosphonates

Bisphosphonates is a Sub of the following Topic

Quick Summary: 39 associated Diseases
NameCumulative KnowledgeArticle CountFocus Articles
Osteonecrosis877Log in | Sign up
Osteoporosis8214Log in | Sign up
Gastric Ulcer668Log in | Sign up
Osteopetrosis602Log in | Sign up
Atrial Fibrillation403Log in | Sign up
Drug-Induced Toxicity: Gastrointestinal313Log in | Sign up
Kidney Damage: Drug-Induced303Log in | Sign up
Drug-Induced Toxicity 232Log in | Sign up
Bone Fractures224Log in | Sign up
Prostate Cancer212Log in | Sign up
Breast Cancer202Log in | Sign up
Kidney Damage142Log in | Sign up
Acid Reflux101Log in | Sign up
Acidosis101Log in | Sign up
Cystic Fibrosis101Log in | Sign up
Drug-Induced Toxicity: L-Thyroxine101Log in | Sign up
Duodenal Ulcer101Log in | Sign up
Esophageal Cancer101Log in | Sign up
Esophageal Diseases101Log in | Sign up
Esophagitis101Log in | Sign up
Kidney Diseases101Log in | Sign up
Kidney Failure: Chronic101Log in | Sign up
Multiple Myeloma101Log in | Sign up
Subtrochanteric stress fractures101Log in | Sign up
Hypocalcemia62Log in | Sign up
Osteopenia51Log in | Sign up
Mevalonate Pathway Enzyme Disorders41Log in | Sign up
Chemically-Induced Liver Damage21Log in | Sign up
Oxidative Stress21Log in | Sign up
Periodontal Wound Healing21Log in | Sign up
Cancer Metastasis11Log in | Sign up
Conjunctival Diseases11Log in | Sign up
Conjunctivitis11Log in | Sign up
Dry Eye Syndromes11Log in | Sign up
Esophageal Ulcer11Log in | Sign up
Gastric Cancer11Log in | Sign up
Gastrointestinal Diseases11Log in | Sign up
Oral Ulceration: Drug-Induced11Log in | Sign up
Prostate Cancer: Bone Metastatic11Log in | Sign up
View the Evidence: Problem Substances

42.4% of those who receive intravenous zoledronic acid experience adverse events of mild to moderate severity.

Pubmed Data : J Clin Endocrinol Metab. 2010 Sep;95(9):4380-7. Epub 2010 Jun 16. PMID: 20554708
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Problem Substances : Bisphosphonates : CK(510) : AC(61), Zoledronic Acid : CK(69) : AC(13)

Alendronate and naproxen are synergistic for development of gastric ulcers.

Pubmed Data : Arch Intern Med. 2001 Jan 8;161(1):107-10. PMID: 11146706
Article Published Date : Jan 08, 2001
Study Type : Human Study
Additional Links
Diseases : Duodenal Ulcer : CK(99) : AC(27), Gastric Ulcer : CK(254) : AC(97)
Additional Keywords : Toxic Drug Synergy : CK(10) : AC(1)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105)
Adverse Pharmacological Actions : Ulcerogenic : CK(66) : AC(9)

Alendronate has been associated with esophageal injury in users.

Pubmed Data : Mod Pathol. 1999 Dec;12(12):1152-7. PMID: 10619269
Article Published Date : Dec 01, 1999
Study Type : Human Study
Additional Links
Diseases : Esophageal Cancer : CK(323) : AC(55), Gastric Ulcer : CK(254) : AC(97)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27)
Adverse Pharmacological Actions : Ulcerogenic : CK(66) : AC(9)

Alendronate is associated with injury and ulceration of the gastric mucosa.

Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal : CK(21) : AC(3), Gastric Ulcer : CK(254) : AC(97), Osteoporosis : CK(1090) : AC(205)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Aspirin : CK(424) : AC(56), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105)
Adverse Pharmacological Actions : Gastrotoxic : CK(20) : AC(2), Ulcerogenic : CK(66) : AC(9)

Alendronate therapy is assoaciated with an emerging pattern of increasingly prevalent subtrochanteric stress fractures.

Pubmed Data : Injury. 2008 Feb;39(2):224-31. Epub 2008 Jan 28. PMID: 18222447
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27)

Alendronate use is associated with an increased risk for atrial fibrillation in women.

Pubmed Data : Arch Intern Med. 2008 Apr 28;168(8):826-31. PMID: 18443257
Article Published Date : Apr 28, 2008
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation : CK(441) : AC(45)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Bisphosphonates : CK(510) : AC(61)

Alendronate use is associated with low-energy femoral shaft fractures.

Pubmed Data : J Orthop Trauma. 2008 May-Jun;22(5):346-50. PMID: 18448990
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteoporosis : CK(1090) : AC(205)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27)

Alendronate users have an increased rate of esophageal and gastric events.

Pubmed Data : Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):371-6. PMID: 19025842
Article Published Date : Sep 01, 2000
Study Type : Human Study
Additional Links
Diseases : Esophageal Diseases : CK(10) : AC(1), Gastric Ulcer : CK(254) : AC(97)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27)
Adverse Pharmacological Actions : Ulcerogenic : CK(66) : AC(9)

Bisphophonate use is associated with gastrointestinal toxicity and osteonecrosis.

Pubmed Data : Curr Opin Endocrinol Diabetes Obes. 2008 Dec;15(6):508-13. PMID: 18971679
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis : CK(112) : AC(16)
Problem Substances : Bisphosphonates : CK(510) : AC(61)

Bisphosphonate exposure was significantly associated with risk of atrial fibrillation serious adverse events in a meta-analysis of four trial datasets.

Pubmed Data : Drug Saf. 2009;32(3):219-28. PMID: 19338379
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation : CK(441) : AC(45)
Problem Substances : Bisphosphonates : CK(510) : AC(61)

Bisphosphonate use in chronic kidney disease is associated wtih adynamic bone disease.

Pubmed Data : Blood Purif. 2010;29(3):293-9. Epub 2010 Jan 21. PMID: 20090316
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Kidney Diseases : CK(424) : AC(71), Kidney Failure: Chronic : CK(143) : AC(19), Osteoporosis : CK(1090) : AC(205)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)
Problem Substances : Bisphosphonates : CK(510) : AC(61)

Bisphosphonate use in early breast cancer does not appeasr to reduce the number of fractures.

Pubmed Data : Gynecol Oncol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061004
Article Published Date : Jan 08, 2010
Study Type : Human Study
Additional Links
Diseases : Bone Fractures : CK(1598) : AC(69), Breast Cancer : CK(2051) : AC(566)
Problem Substances : Bisphosphonates : CK(510) : AC(61)

Bisphosphonate use is associated with a significant increase in the risk of serious atrial fibrillation in postmenopausal women.

Pubmed Data : Int J Cardiol. 2010 Jan 3. Epub 2010 Jan 3. PMID: 20051297
Article Published Date : Jan 03, 2010
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation : CK(441) : AC(45)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27)

Bisphosphonate use is associated with an increased risk of deep venous thromboembolism and pulmonary embolism.

Pubmed Data : Osteoporos Int. 2009 Oct 27. Epub 2009 Oct 27. PMID: 19859641
Article Published Date : Oct 27, 2009
Study Type : Human Study
Additional Links
Problem Substances : Bisphosphonates : CK(510) : AC(61)

Bisphosphonate use is associated with osteonecrosis of the jaw.

Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):e1-8. Epub 2009 Jul 1. PMID: 19570696
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis : CK(112) : AC(16)
Problem Substances : Bisphosphonates : CK(510) : AC(61)

Bisphosphonate use may cause osteopetrosis.

Pubmed Data : J Bone Miner Res. 2008 Oct;23(10):1698-707. PMID: 18505375
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteopetrosis : CK(22) : AC(3)
Problem Substances : Bisphosphonates : CK(510) : AC(61), Pamidronate : CK(33) : AC(6)

Bisphosphonates are less effective in women receiving TSH-suppressing doses of thyroxine.

Pubmed Data : Thyroid. 2009 May;19(5):437-42. PMID: 19415993
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: L-Thyroxine : CK(23) : AC(8)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Thyroxine : CK(104) : AC(15)

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.

Pubmed Data : Am J Gastroenterol. 1997 Aug;92(8):1322-5. PMID: 9260798
Article Published Date : Aug 01, 1997
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal : CK(21) : AC(3), Gastric Ulcer : CK(254) : AC(97)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Aspirin : CK(424) : AC(56), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105), Pamidronate : CK(33) : AC(6)
Adverse Pharmacological Actions : Gastrotoxic : CK(20) : AC(2), Ulcerogenic : CK(66) : AC(9)

Bisphosphonates have been linked to osteonecrosis and osteopetrosis of the jaws.

Pubmed Data : J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75. PMID: 16243172
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis : CK(112) : AC(16), Osteopetrosis : CK(22) : AC(3)
Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Bisphosphonates : CK(510) : AC(61), Pamidronate : CK(33) : AC(6), Zoledronic Acid : CK(69) : AC(13)

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How Too Much Calcium Can Break Your Bones
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Did you know that most calcium supplements on the market are basically limestone? Yes, that's chalk. Conceal it within a capsule, a slickly glazed tablet, or in the form of a silky smooth liquid, and it is magically transformed into a "calcium supplement": easy to swallow, “good for the bones" and a very profitable commodity for both the dietary supplement and mining industries. After all, a sizable portion of the Earth's crust is composed of the stuff.

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