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Article Count - 16
Cumulative Knowledge - 135

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Quick Summary: Current access displays 2 out of 17 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Diabetes Mellitus: Type 1: Prevention	53	5	Log in \| Sign up
Casein Intolerance	20	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 5 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Cardiotoxic	21	2	Log in \| Sign up
Diabetogenic	13	3	Log in \| Sign up

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View the Evidence: Problem Substances

The beta-casein A1 protein variant of cow's milk may contribute to increased risk of diabetes type 1.

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Pubmed Data : Diabetologia. 1999 Mar;42(3):292-6. PMID: 10096780

Article Published Date : Mar 01, 1999

Study Type : Meta Analysis

Additional Links

Diseases : Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16)

The consumption of cow milk A1 beta-casein is associated with increased risk of ischaemic heart disease and type 1 diabets.

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Pubmed Data : N Z Med J. 2003 Jan 24;116(1168):U295. Epub 2003 Jan 24. PMID: 12601419

Article Published Date : Jan 24, 2003

Study Type : Meta Analysis

Additional Links

Diseases : Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30), Heart Disease: Ischemic : CK(201) : AC(16)

Problem Substances : Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

There is evidence supporting the beneficial effect of a gluten- and casein-free diet for autistic spectrum disorder.

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Pubmed Data : Cochrane Database Syst Rev. 2004(2):CD003498. PMID: 15106205

Article Published Date : Jan 01, 2004

Study Type : Meta Analysis

Additional Links

Diseases : Autism Spectrum Disorders : CK(1140) : AC(108)

Therapeutic Actions : Dietary Modification: Cow's Milk/Casein Free : CK(43) : AC(2), Dietary Modification: Wheat/Gluten Free : CK(259) : AC(29)

Problem Substances : Casein : CK(135) : AC(16), Gluten : CK(1755) : AC(144)

A Gluten and casein-free diet may have a therapeutic effect in autism spectrum and attention deficit disorders.

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Pubmed Data : Nutr Neurosci. 2010 Apr;13(2):87-100. PMID: 20406576

Article Published Date : Apr 01, 2010

Study Type : Human Study

Additional Links

Diseases : Attention Deficit Disorder : CK(134) : AC(12), Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30), Autism Spectrum Disorders : CK(1140) : AC(108)

Additional Keywords : Gluten and ADHD : CK(20) : AC(2)

Problem Substances : Casein : CK(135) : AC(16), Gluten : CK(1755) : AC(144)

Bovine alpha 1 casein that is considered a major cow's milk allergen is readily secreted in human milk.

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Pubmed Data : J Biol Regul Homeost Agents. 2012 Jul-Sep;26(3 Suppl):39-42. PMID: 23158513

Article Published Date : Jun 30, 2012

Study Type : Human Study

Additional Links

Diseases : Allergy: Cow's Milk : CK(92) : AC(18), Breastfeeding: Complications : CK(187) : AC(20), Breastfeeding Concerns: Chemical Exposure : CK(91) : AC(15)

Problem Substances : Bovine alpha-S1-casein : CK(10) : AC(1), Casein : CK(135) : AC(16)

Elevated IgA antibodies to gluten and gliadin proteins and to casein in milk have been found in patients with Rett syndrome.

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Pubmed Data : Autism. 2006 Mar;10(2):189-97. PMID: 16613867

Article Published Date : Mar 01, 2006

Study Type : Human Study

Additional Links

Diseases : Casein Intolerance : CK(44) : AC(5), Gluten Intolerance : CK(236) : AC(33), Rett Syndrome : CK(20) : AC(2), Wheat Intolerance : CK(2480) : AC(231)

Problem Substances : Casein : CK(135) : AC(16), Gliadin : CK(2509) : AC(110), Gluten : CK(1755) : AC(144)

Highly significant increases compared with controls were found in patients with multiple sclerosis for IgA and IgG antibodies against gliadin and gluten and IgA antibodies against casein.

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Pubmed Data : Acta Neurol Scand. 2004 Oct;110(4):239-41. PMID: 15355487

Article Published Date : Oct 01, 2004

Study Type : Human Study

Additional Links

Diseases : Casein Intolerance : CK(44) : AC(5), Gluten Intolerance : CK(236) : AC(33), Multiple Sclerosis : CK(716) : AC(133)

Problem Substances : Casein : CK(135) : AC(16), Gliadin : CK(2509) : AC(110), Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lower consumption of cow milk protein A1 beta-casein at 2 years of age, rather than consumption among 11- to 14-year-old adolescents, may explain the lower incidence of type 1 diabetes in Iceland than in Scandinavia.

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Pubmed Data : Ann Nutr Metab. 2006;50(3):177-83. Epub 2006 Jan 10. PMID: 16407643

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Problem Substances : Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7)

The beta-casein A1 protein variant of cow's milk may contribute to increased risk of diabetes type 1. - Article 2.

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Pubmed Data : Diabetes Nutr Metab. 2002 Aug;15(4):240-5. PMID: 12416661

Article Published Date : Aug 01, 2002

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30)

Problem Substances : Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7), Cow Milk : CK(368) : AC(46)

Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Autism and Dietary Therapy: Case Report and Review of the Literature.

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Pubmed Data : J Child Neurol. 2013 May 10. Epub 2013 May 10. PMID: 23666039

Article Published Date : May 09, 2013

Study Type : Human: Case Report

Additional Links

Substances : Medium Chain Triglycerides : CK(47) : AC(13)

Diseases : Autism : CK(1262) : AC(65), Autism Spectrum Disorders : CK(1140) : AC(108), Casein Intolerance : CK(44) : AC(5), Wheat Intolerance : CK(2480) : AC(231)

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic : CK(159) : AC(24), Dietary Modification: Wheat/Gluten Free : CK(259) : AC(29)

Problem Substances : Casein : CK(135) : AC(16), Wheat : CK(2542) : AC(309)

A casein- and wheat-free diet was associated with the lowest rate of autoimmune diabetes (type 1) development in mice.

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Pubmed Data : Ann Nutr Metab. 2009;54(3):208-17. Epub 2009 May 27. PMID: 19478481

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30)

Problem Substances : Casein : CK(135) : AC(16), Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Thermolyzed casein promotes colon carcinogenesis.

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Pubmed Data : Nutr Cancer. 1995;23(3):271-81. PMID: 7603887

Article Published Date : Jan 01, 1995

Study Type : Animal Study

Additional Links

Diseases : Colon Cancer : CK(895) : AC(233)

Problem Substances : Casein : CK(135) : AC(16)

Adverse Pharmacological Actions : Carcinogen : CK(59) : AC(11)

Thermolyzed protein (casein) promotes aberrant crypt foci and cancer in the rat colon.

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Pubmed Data : J Natl Cancer Inst. 1992 Jul 1;84(13):1026-30. PMID: 1608054

Article Published Date : Jul 01, 1992

Study Type : Animal Study

Additional Links

Diseases : Colon Cancer : CK(895) : AC(233)

Problem Substances : Casein : CK(135) : AC(16)

Adverse Pharmacological Actions : Carcinogen : CK(59) : AC(11)

Zein, casein and gluten down-regulate tryptophan production in the rat brain.

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Pubmed Data : Physiol Behav. 2009 Aug 4 ;98(1-2):156-62. Epub 2009 May 18. PMID: 19454292

Article Published Date : Aug 04, 2009

Study Type : Animal Study

Additional Links

Diseases : Serotonin Disorders : CK(17) : AC(5)

Problem Substances : Casein : CK(135) : AC(16), Gluten : CK(1755) : AC(144), Zein : CK(2) : AC(1)

Adverse Pharmacological Actions : Serotonin Down-Regulation : CK(2) : AC(1)

Beta casein A1 and B yields beta-casomophin 7 (BCM-7), a potentially harmful peptide.

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Pubmed Data : J Appl Genet. 2007;48(3):189-98. PMID: 17666771

Article Published Date : Jan 01, 2007

Study Type : Review

Additional Links

Diseases : Allergy: Cow's Milk : CK(92) : AC(18)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7)

Beta-casomorphin may contribute to apnea in sudden infant death syndrome.

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Pubmed Data : Peptides. 2003 Jun;24(6):937-43. PMID: 12948848

Article Published Date : Jun 01, 2003

Study Type : Commentary

Additional Links

Diseases : Apnea : CK(69) : AC(11), Sudden Infant Death Syndrome (SIDS) : CK(138) : AC(18)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7)

Ischaemic heart disease mortality and diabetes type 1 risk may be associated with beta-casein A1 consumption.

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Pubmed Data : Med Hypotheses. 2001 Feb;56(2):262-72. PMID: 11425301

Article Published Date : Feb 01, 2001

Study Type : Review

Additional Links

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30)

Problem Substances : Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Diabetogenic : CK(166) : AC(14)

Opioid peptides derived from milk might be one of the etiological factors for sudden infant death syndrome and near miss sudden infant death syndrome.

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Pubmed Data : Med Hypotheses. 1988 Nov;27(3):181-7. PMID: 3062337

Article Published Date : Nov 01, 1988

Study Type : Commentary

Additional Links

Diseases : Sudden Infant Death Syndrome (SIDS) : CK(138) : AC(18)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7), Cow Milk : CK(368) : AC(46)

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