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Article Count - 44
Cumulative Knowledge - 375

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Quick Summary: Current access displays 2 out of 35 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Endometrial Cancer	116	15	Log in \| Sign up
Breast Cancer	93	11	Log in \| Sign up

Quick Summary: Current access displays 2 out of 15 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Carcinogenic	110	16	Log in \| Sign up
Neurotoxic	40	3	Log in \| Sign up

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View the Evidence: Problem Substances

Five or more years of tamoxifen use increases risk of cataracts in breast cancer patients.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2000 Mar;60(2):167-72. PMID: 10845279

Article Published Date : Mar 01, 2000

Study Type : Meta Analysis

Additional Links

Diseases : Cataract : CK(182) : AC(55), Drug-Induced Toxicity : CK(560) : AC(78)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Postoperative tamoxifen for ductal carcinoma in situ does not reduce overall mortality.

Click here to read the entire abstract

Pubmed Data : Cochrane Database Syst Rev. 2012 ;10:CD007847. Epub 2012 Oct 17. PMID: 23076938

Article Published Date : Dec 31, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Tamoxifen interferes with cognitive function in breast cancer patients.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2000 Nov;64(2):165-76. PMID: 11194452

Article Published Date : Nov 01, 2000

Study Type : Meta Analysis

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Drug-Induced Toxicity : CK(560) : AC(78), Memory Disorders: Drug-Induced : CK(77) : AC(12)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Tamoxifen use may cause endometrial cancer, as well as being associated with poorer prognosis.

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 1998 May 4;76(3):325-30. PMID: 9579567

Article Published Date : May 04, 1998

Study Type : Meta Analysis

Additional Links

Diseases : Endometrial Cancer : CK(269) : AC(45)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

There are high rates of behavioral symptoms in breast cancer survivors, particularly those treated with chemotherapy

Click here to read the entire abstract

Pubmed Data : J Clin Oncol. 2011 Aug 8. Epub 2011 Aug 8. PMID: 21825266

Article Published Date : Aug 08, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Depression : CK(674) : AC(88), Fatigue : CK(194) : AC(30), Inflammation : CK(1077) : AC(363), Insomnia : CK(471) : AC(56)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Problem Substances : Chemotherapy : CK(348) : AC(44)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Tumor necrosis factorα (TNFα) up-regulation : CK(42) : AC(4)

Two year treatment with Tamoxifen and Arimidex result in a number of side effects which reduce quality of life.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2006 Dec;100(3):273-84. Epub 2006 Jun 21. PMID: 16944295

Article Published Date : Dec 01, 2006

Study Type : Meta Analysis

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Arimidex : CK(122) : AC(12), Tamoxifen : CK(319) : AC(39)

Adjuvant tamoxifen therapy for early stage breast cancer increases the risk of second primarly malignancies such as endometrial, colon and somatch cancer.

Click here to read the entire abstract

Pubmed Data : J Natl Cancer Inst. 1995 May 3;87(9):645-51. PMID: 7752269

Article Published Date : May 03, 1995

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Colorectal Cancer : CK(877) : AC(321), Endometrial Cancer : CK(269) : AC(45), Gastric Cancer : CK(373) : AC(111)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Biweekly oxaliplatin and irinotecan chemotherapy in advanced gastric cancer results in a median overall survival time of 9.5 months.

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2008 Sep-Oct;28(5B):2901-5. PMID: 19031932

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Diseases : Gastric Cancer : CK(373) : AC(111)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Problem Substances : Chemotherapy : CK(348) : AC(44), Irinotecan : CK(30) : AC(3), Oxaliplatin : CK(30) : AC(3)

Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma.

Click here to read the entire abstract

Pubmed Data : Ann Oncol. 2008 Jul ;19(7):1327-30. Epub 2008 Mar 17. PMID: 18349031

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Diseases : Lymphoma: Mantle Cell : CK(35) : AC(8)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)

Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Problem Substances : Chemotherapy : CK(348) : AC(44)

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.

Click here to read the entire abstract

Pubmed Data : J Psychosoc Oncol. 2011 Sep-Oct;29(5):499-514. PMID: 21882931

Article Published Date : Sep 01, 2011

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Memory Disorders: Drug-Induced : CK(77) : AC(12), Memory Loss : CK(113) : AC(32)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Tamoxifen and Arimidex (anastrozole) can have detrimental effects on higher brain funtions.

Click here to read the entire abstract

Pubmed Data : J Clin Exp Neuropsychol. 2010 Mar 24:1-11. Epub 2010 Mar 24. PMID: 20336566

Article Published Date : Mar 24, 2010

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Cognitive Decline/Dysfunction : CK(522) : AC(87)

Problem Substances : Arimidex : CK(122) : AC(12), Tamoxifen : CK(319) : AC(39)

Tamoxifen and raloxifene adversely affect cognitive function in older women.

Click here to read the entire abstract

Pubmed Data : J Womens Health (Larchmt). 2010 Mar ;19(3):371-9. PMID: 20136553

Article Published Date : Mar 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Problem Substances : Raloxifene : CK(103) : AC(11), Tamoxifen : CK(319) : AC(39)

Tamoxifen causes DNA adducs in the endometrium of women.

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2000 Aug;21(8):1461-7. PMID: 10910945

Article Published Date : Aug 01, 2000

Study Type : Human Study

Additional Links

Diseases : Endometrial Cancer : CK(269) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

Tamoxifen has been shown to cause endometrial cancer in humans.

Click here to read the entire abstract

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):105-10. PMID: 11267730

Article Published Date : Mar 01, 2001

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Endometrial Cancer : CK(269) : AC(45)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Tamoxifen increases the risk of endometrial hyperplasia and carcinoma in breast cancer patients.

Click here to read the entire abstract

Pubmed Data : Vopr Onkol. 2003;49(2):198-204. PMID: 12785205

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Diseases : Endometrial Cancer : CK(269) : AC(45)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Tamoxifen may induce fatty liver in patients with breast cancer.

Click here to read the entire abstract

Pubmed Data : AJR Am J Roentgenol. 2003 Jan;180(1):129-34. PMID: 12490491

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Diseases : Fatty Liver : CK(493) : AC(122)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Tamoxifen therapy has been associated with the development of acute myeloid leukemia during breast cancer treatment.

Click here to read the entire abstract

Pubmed Data : Med Oncol. 1997 Mar;14(1):61-2. PMID: 9232614

Article Published Date : Mar 01, 1997

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Tamoxifen treatment for breast cancer in Japanese women results in an increased risk for endomentrial and stomach cancer.

Click here to read the entire abstract

Pubmed Data : Ann Oncol. 2000 Dec;11(12):1537-43. PMID: 11205460

Article Published Date : Dec 01, 2000

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Endometrial Cancer : CK(269) : AC(45), Gastric Cancer : CK(373) : AC(111)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Tamoxifen treatment for breast cancer may result in fatty liver.

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Fatty Liver : CK(493) : AC(122)

Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Drug: Doxorubicin : CK(141) : AC(55), Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Tamoxifen treatment for breast cancer results in one-third of all patients developing endometrial polyps, hyperplasia, metaplasia, consistent with an estrogen-agonist effect.

Click here to read the entire abstract

Pubmed Data : Gynecol Oncol. 2000 Aug;78(2):181-6. PMID: 10926800

Article Published Date : Aug 01, 2000

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Endometrial Cancer : CK(269) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Estrogen Agonist : CK(13) : AC(4), Estrogenic : CK(59) : AC(12)

Tamoxifen treatment in breast cancer may induce non-alcoholic fatty liver.

Click here to read the entire abstract

Pubmed Data : Intern Med. 2002 May;41(5):345-50. PMID: 12058881

Article Published Date : May 01, 2002

Study Type : Human Study

Additional Links

Diseases : Fatty Liver : CK(493) : AC(122)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Tamoxifen treatment increases the risk of endometrial cancer in both premenopausal and postmenopausal women

Click here to read the entire abstract

Pubmed Data : J Natl Cancer Inst. 2005 Mar 2;97(5):375-84. PMID: 15741574

Article Published Date : Mar 02, 2005

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Endometrial Cancer : CK(269) : AC(45)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Tamoxifen treatment results in adverse structural and functional changes in the brain in women.

Click here to read the entire abstract

Pubmed Data : Neuroimage. 2004 Jan;21(1):364-71. PMID: 14741674

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Memory Disorders: Drug-Induced : CK(77) : AC(12)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Tamoxifen usage is associated with bone loss in patients who continued to menstruate after adjuvant chemotherapy.

Click here to read the entire abstract

Pubmed Data : J Clin Oncol. 2006 Feb 1;24(4):675-80. PMID: 16446340

Article Published Date : Feb 01, 2006

Study Type : Human Study

Additional Links

Diseases : Osteoporosis : CK(1171) : AC(205)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Tamoxifen use is associated with increased risk for endomentrial polyps and cancer.

Click here to read the entire abstract

Pubmed Data : Gynecol Obstet Fertil. 2005 Dec;33(12):975-9. PMID: 16321556

Article Published Date : Dec 01, 2005

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Endometrial Cancer : CK(269) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogen : CK(59) : AC(11)

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