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Cholesterol Lowering Drugs

Cholesterol Lowering Drugs

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Article Count - 349
Cumulative Knowledge - 2274

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Quick Summary: Current access displays 2 out of 273 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Statin-Induced Pathologies	1308	229	Log in \| Sign up
Myopathies	186	39	Log in \| Sign up

Quick Summary: Current access displays 2 out of 25 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Myotoxicity	241	58	Log in \| Sign up
Neurotoxic	215	39	Log in \| Sign up

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View the Evidence: Problem Substances

In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Click here to read the entire abstract

Pubmed Data : JAMA. 2011 Jun 22;305(24):2556-64. PMID: 21693744

Article Published Date : Jun 22, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Insomnia is a possible statin-associated psychiatric adverse effect.

Click here to read the entire abstract

Pubmed Data : Drug Saf. 2008;31(12):1115-23. PMID: 19026028

Article Published Date : Jan 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Insomnia : CK(471) : AC(56)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Lipid-lowering drugs contribute to erectile dysfunction.

Click here to read the entire abstract

Pubmed Data : Fam Pract. 2002 Feb ;19(1):95-8. PMID: 11818357

Article Published Date : Feb 01, 2002

Study Type : Meta Analysis

Additional Links

Diseases : Erectile Dysfunction : CK(510) : AC(41), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3969) : AC(465)

Lowering cholesterol concentrations may increase mortality.

Click here to read the entire abstract

Pubmed Data : BMJ. 1990 Aug 11 ;301(6747):309-14. PMID: 2144195

Article Published Date : Aug 11, 1990

Study Type : Meta Analysis

Additional Links

Substances : Cholesterol : CK(403) : AC(45)

Diseases : Mortality: All-Cause : CK(644) : AC(55), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349)

Muscle complaints occur in 10% or more of patients started on high-dose statins.

Click here to read the entire abstract

Pubmed Data : Curr Opin Lipidol. 2007 Aug;18(4):401-8. PMID: 17620856

Article Published Date : Aug 01, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Myopathies : CK(252) : AC(51)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Pancreatitis, while rare, is a possible side effect of taking statin drugs.

Click here to read the entire abstract

Pubmed Data : Drug Saf. 2006 ;29(12):1123-32. PMID: 17147459

Article Published Date : Jan 01, 2006

Study Type : Meta Analysis

Additional Links

Diseases : Pancreatitis : CK(164) : AC(40), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations.

Click here to read the entire abstract

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996

Article Published Date : Sep 14, 2011

Study Type : Meta Analysis

Additional Links

Diseases : AST: Elevated : CK(26) : AC(4), Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Elevated: ALT : CK(23) : AC(2), Elevated: Creatinine Kinase : CK(33) : AC(3), GGT : CK(73) : AC(10)

Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Statin drugs increase the risk of diabetes.

Click here to read the entire abstract

Pubmed Data : Curr Opin Cardiol. 2011 Jul;26(4):342-7. PMID: 21499090

Article Published Date : Jul 01, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Drug-Induced Toxicity : CK(560) : AC(78), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Statin use is associated with an increased incidence of interstitial lung disease.

Click here to read the entire abstract

Pubmed Data : Chest. 2008 Oct;134(4):824-30. Epub 2008 Aug 8. PMID: 18689579

Article Published Date : Oct 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Hyperlipidemia : CK(1211) : AC(109), Interstitial Lung Diseases : CK(70) : AC(12)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Statins are not associated with a reduced risk of pneumonia.

Click here to read the entire abstract

Pubmed Data : Eur J Clin Pharmacol. 2011 Nov 15. Epub 2011 Nov 15. PMID: 22083167

Article Published Date : Nov 15, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Pneumonia : CK(330) : AC(40)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Statins may partially operate by lowering testosterone.

Click here to read the entire abstract

Pubmed Data : BMC Med. 2013 Feb 28 ;11(1):57. Epub 2013 Feb 28. PMID: 23448151

Article Published Date : Feb 27, 2013

Study Type : Meta Analysis

Additional Links

Diseases : Testosterone: Too Low : CK(369) : AC(70)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Endocrine Disruptor: Testes : CK(1) : AC(1)

The use of statins for LDL suppression is associated with increased risk for cancer.

Click here to read the entire abstract

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392

Article Published Date : Jul 31, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Cancers: All : CK(9062) : AC(2869), Chemically-Induced Liver Damage : CK(475) : AC(175), High Cholesterol : CK(1718) : AC(198), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

There are 17 randomized trials on statin treatment showing an increased incidence of diabetes.

Click here to read the entire abstract

Pubmed Data : QJM. 2010 Oct 7. Epub 2010 Oct 7. PMID: 20934984

Article Published Date : Oct 07, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Blood Sugar Problems : CK(4050) : AC(693), Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Concomitant use of erythromycin and simvastatin may increase the cataract risk.

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2001 Sep 10 ;161(16):2021-6. PMID: 11525705

Article Published Date : Sep 10, 2001

Study Type : Human Study

Additional Links

Diseases : Cataract : CK(182) : AC(55), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Forty-five of 358 statin-treated patients demonstrated a 15% increase in LDL cholesterol levels, leading to suspicion of statin escape phenomenon.

Click here to read the entire abstract

Pubmed Data : Eur J Intern Med. 2005 Jun ;16(3):192-194. PMID: 15967335

Article Published Date : Jun 01, 2005

Study Type : Human Study

Additional Links

Diseases : Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

"High antiphospholipid antibody levels are associated with statin use and may reflect chronic endothelial damage in non-autoimmune thrombosis."

Click here to read the entire abstract

Pubmed Data : J Clin Pathol. 2012 Mar 3. Epub 2012 Mar 3. PMID: 22389514

Article Published Date : Mar 03, 2012

Study Type : Human Study

Additional Links

Diseases : Endothelial Damage : CK(31) : AC(10), Thrombosis : CK(657) : AC(74)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

"Lipid-lowering drugs and essential omega-6 and omega-3 fatty acids in patients with coronary heart disease."

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2005 Feb ;15(1):36-41. PMID: 15871849

Article Published Date : Jan 31, 2005

Study Type : Human Study

Additional Links

Diseases : Coronary Artery Disease : CK(1305) : AC(136), Dietary Fatty Acid Imbalance: Omega3/Omega6 Ratio : CK(33) : AC(5), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Omega-3 Fatty Acid Deficiency : CK(20) : AC(1), Statin-Induced Pathologies : CK(1570) : AC(315)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

A number of commonly used drugs interfere with the absorption of lovothyroxine.

Click here to read the entire abstract

Pubmed Data : Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92. PMID: 19942153

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism : CK(537) : AC(78)

Problem Substances : Antacids: Aluminium-Containing : CK(22) : AC(3), Bile Acid Sequestrants : CK(10) : AC(1), Calcium Carbonate : CK(176) : AC(19), Ferrous Sulphate : CK(22) : AC(3), Phosphate Binders : CK(10) : AC(1), Proton-Pump Inhibitors : CK(218) : AC(27), Raloxifene : CK(103) : AC(11), Sucralfate : CK(10) : AC(1)

After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.

Click here to read the entire abstract

Pubmed Data : Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID: 23183519

Article Published Date : Nov 27, 2012

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Death: Statin-Induced : CK(14) : AC(3), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Age-related cataract is associated with type 2 diabetes and statin use.

Click here to read the entire abstract

Pubmed Data : Optom Vis Sci. 2012 Aug ;89(8):1165-71. PMID: 22797512

Article Published Date : Jul 31, 2012

Study Type : Human Study

Additional Links

Diseases : Cataract : CK(182) : AC(55)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Although statin drugs decrease LDL cholesterol in end-stage kidney disease, their use does not lower morbidity or mortality.

Click here to read the entire abstract

Pubmed Data : Pharmacotherapy. 2010 Aug;30(8):823-9. PMID: 20653359

Article Published Date : Aug 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality : CK(703) : AC(67), Hemodialysis : CK(393) : AC(38), Kidney Diseases : CK(424) : AC(71), Renal Failure: Chronic : CK(305) : AC(1)

Problem Substances : Atorvastatin : CK(491) : AC(90), Rosuvastatin : CK(68) : AC(16), Statin Drugs : CK(3969) : AC(465)

Among top sports performers only about 20% tolerate statin treatment without side-effects.

Click here to read the entire abstract

Pubmed Data : Br J Clin Pharmacol. 2004 Apr ;57(4):525-8. PMID: 15025753

Article Published Date : Apr 01, 2004

Study Type : Human Study

Additional Links

Diseases : Athletic Performance : CK(479) : AC(61), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

An adverse grapefruit juice-simvastatin interaction has been identified.

Click here to read the entire abstract

Pubmed Data : Clin Pharmacol Ther. 1998 Nov ;64(5):477-83. PMID: 9834039

Article Published Date : Nov 01, 1998

Study Type : Human Study

Additional Links

Substances : Grapefruit : CK(109) : AC(30)

Diseases : Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

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