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Cholinesterase Inhibitor Drugs
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Additional Topics Details for this Page
Article Count
- 9
Cumulative Knowledge
- 135
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Related Topics
The Following are Sub-Topics of Cholinesterase Inhibitor Drugs
Galantamine
Donepezil (trade name Aricept)
Rivastigmine
What is Cumulative Knowledge?
Cumulative Knowledge
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Quick Summary: Current access displays 2 out of 13 associated Diseases
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Focus Articles
Alzheimer's Disease
89
6
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Bradycardia
63
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Quick Summary: 1 associated Adverse Pharmacological Actions
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Neurotoxic
46
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View the Evidence: Problem Substances
21 percent of patients who receive donepezil discontinue treatment due to adverse side effects.
Click here to read the entire abstract
Pubmed Data
: Ugeskr Laeger. 2009 Dec 7;171(50):3690-3. PMID:
20003864
Article Published Date
: Dec 07, 2009
Study Type
: Meta Analysis
Additional Links
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
,
Diarrhea: Drug-Associated : CK(22) : AC(2)
Problem Substances
:
Donepezil (trade name Aricept) : CK(89) : AC(8)
Cholinesterase inhibitor drug use is associated with increased incidence of bradycardia.
Click here to read the entire abstract
Pubmed Data
: J Am Geriatr Soc. 2009 Nov;57(11):1997-2003. Epub 2009 Sep 28. PMID:
19793162
Article Published Date
: Nov 01, 2009
Study Type
: Meta Analysis
Additional Links
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
,
Bradycardia : CK(56) : AC(8)
,
Dementia : CK(225) : AC(31)
Problem Substances
:
Cholinesterase Inhibitor Drugs : CK(135) : AC(9)
,
Donepezil (trade name Aricept) : CK(89) : AC(8)
Donepezil and memantine are known to cause bradycardia and to reduce the epileptogenic threshold.
Click here to read the entire abstract
Pubmed Data
: Therapie. 2010 May-Jun;65(3):255-9. Epub 2010 Aug 11. PMID:
20699079
Article Published Date
: May 01, 2010
Study Type
: Meta Analysis
Additional Links
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
,
Bradycardia : CK(56) : AC(8)
,
Epileptic Seizures : CK(47) : AC(6)
Problem Substances
:
Donepezil (trade name Aricept) : CK(89) : AC(8)
,
Memantine : CK(42) : AC(3)
The WHO reports 71,471 seizures from a variety of neuroactive drugs between 1968-2006.
Click here to read the entire abstract
Pubmed Data
: Seizure. 2010 Mar;19(2):69-73. Epub 2009 Dec 24. PMID:
20036167
Article Published Date
: Mar 01, 2010
Study Type
: Meta Analysis
Additional Links
Diseases
:
Seizures : CK(122) : AC(28)
Problem Substances
:
Amoxapine : CK(20) : AC(1)
,
Buproprione : CK(20) : AC(1)
,
Chlorprothiexene : CK(20) : AC(1)
,
Clozapine : CK(20) : AC(1)
,
Donepezil (trade name Aricept) : CK(89) : AC(8)
,
Escitaloprame : CK(20) : AC(1)
,
Maprotilene : CK(20) : AC(1)
,
Quetiapine : CK(20) : AC(1)
,
Rivastigmine : CK(21) : AC(2)
,
Trimipramine : CK(20) : AC(1)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
A case of dementia with Lewy bodies showing cervical dystonia after donepezil administration has been reported.
Click here to read the entire abstract
Pubmed Data
: Rinsho Shinkeigaku. 2010 Mar;50(3):147-50. PMID:
20235482
Article Published Date
: Mar 01, 2010
Study Type
: Human: Case Report
Additional Links
Diseases
:
Cervical Dystonia : CK(3) : AC(1)
,
Liver Failure: Drug Induced : CK(23) : AC(3)
Problem Substances
:
Donepezil (trade name Aricept) : CK(89) : AC(8)
Donepezil-associated bradyarrhythmia in a patient with dementia with Lewy bodies (DLB) has been reported.
Click here to read the entire abstract
Pubmed Data
: Alzheimer Dis Assoc Disord. 2010 Apr-Jun;24(2):209-11. PMID:
20505440
Article Published Date
: Apr 01, 2010
Study Type
: Human: Case Report
Additional Links
Diseases
:
Bradycardia : CK(56) : AC(8)
,
Dementia : CK(225) : AC(31)
,
Dementia with Lewy bodies (DLB) : CK(3) : AC(1)
Problem Substances
:
Donepezil (trade name Aricept) : CK(89) : AC(8)
Two cases of suicide in patients with a diagnosis of probable Alzheimer disease and who were treated with cholinesterase inhibitor drugs have been reported.
Click here to read the entire abstract
Pubmed Data
: Alzheimer Dis Assoc Disord. 1999 Apr-Jun;13(2):88-90. PMID:
10372951
Article Published Date
: Apr 01, 1999
Study Type
: Human: Case Report
Additional Links
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
Problem Substances
:
Cholinesterase Inhibitor Drugs : CK(135) : AC(9)
,
Eptastigmine : CK(3) : AC(1)
Donepezil markedly potentiates memantine neurotoxicity.
Click here to read the entire abstract
Pubmed Data
: Neurobiol Aging. 2008 Feb ;29(2):153-67. Epub 2006 Nov 16. PMID:
17112636
Article Published Date
: Feb 01, 2008
Study Type
: Animal Study
Additional Links
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
,
Neurodegenerative Diseases : CK(1743) : AC(420)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
Additional Keywords
:
Drug Synergy : CK(327) : AC(147)
Problem Substances
:
Donepezil (trade name Aricept) : CK(89) : AC(8)
,
Memantine : CK(42) : AC(3)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
The cholinesterase inhibitor drugs may increase tremor and exacerbation of Parkinson's disease.
Click here to read the entire abstract
Pubmed Data
: Prescrire Int. 2007 Oct;16(91):197-8. PMID:
17926835
Article Published Date
: Oct 01, 2007
Study Type
: Review
Additional Links
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
,
Dementia : CK(225) : AC(31)
,
Parkinson Disease : CK(543) : AC(79)
,
Parkinsonism : CK(12) : AC(8)
,
Tremor : CK(39) : AC(8)
Problem Substances
:
Cholinesterase Inhibitor Drugs : CK(135) : AC(9)
,
Donepezil (trade name Aricept) : CK(89) : AC(8)
,
Galantamine : CK(1) : AC(1)
,
Rivastigmine : CK(21) : AC(2)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
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