Fluoride

Fluoride

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View the Evidence: Problem Substances

Children who live in a fluorosis area have 5 times higher odds of developing low IQ than those who live in a nonfluorosis area or a slight fluorosis area.

Pubmed Data : Biol Trace Elem Res. 2008;126(1-3):115-20. Epub 2008 Aug 10. PMID: 18695947
Article Published Date : Jan 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Childhood Cognitive Disorders : CK(180) : AC(14), Cognitive Decline/Dysfunction : CK(522) : AC(87), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Nutrition: Learning/Intelligence of Offspring : CK(118) : AC(15)
Problem Substances : Fluoride : CK(264) : AC(45)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Exposure to high fluoride concentrations in drinking water is associated with decreased birth rates.

Pubmed Data : J Toxicol Environ Health. 1994 May ;42(1):109-21. PMID: 8169995
Article Published Date : Apr 30, 1994
Study Type : Meta Analysis
Additional Links
Diseases : Infertility: Female : CK(182) : AC(33), Infertility: Male : CK(209) : AC(52)
Additional Keywords : causes of decreased birth rates
Problem Substances : Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Anti-Fertility : CK(6) : AC(1)

Exposure to high levels of fluoride may adversely influence children's intelligence development.

Pubmed Data : Zhongguo Dang Dai Er Ke Za Zhi. 2008 Dec;10(6):723-5. PMID: 19102839
Article Published Date : Dec 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Childhood Cognitive Disorders : CK(180) : AC(14), Cognitive Decline/Dysfunction : CK(522) : AC(87), Fluoride Toxicity : CK(146) : AC(40), Fluorosis : CK(219) : AC(6), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Nutrition: Learning/Intelligence of Offspring : CK(118) : AC(15)
Problem Substances : Fluoride : CK(264) : AC(45)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Infant formula consumption may be associated with an increased risk of developing at least some detectable level of enamel fluorosis.

Pubmed Data : Evid Based Dent. 2009;10(3):73. PMID: 19820737
Article Published Date : Jan 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Fluoride Toxicity : CK(146) : AC(40), Fluorosis : CK(219) : AC(6)
Problem Substances : Fluoride : CK(264) : AC(45), Infant Formula : CK(485) : AC(63)

An increased risk of spontaneous abortion among fabrication workers has been linked to fluoride compound and photoresist and developed solvents (PDS) exposure.

Pubmed Data : Am J Ind Med. 1995 Dec ;28(6):751-69. PMID: 8588562
Article Published Date : Nov 30, 1995
Study Type : Human Study
Additional Links
Diseases : Abortion: Spontaneous : CK(204) : AC(29), Infertility: Female : CK(182) : AC(33)
Problem Substances : Fluoride : CK(264) : AC(45), Photoresist and developed solvents (PDS) : CK(10) : AC(1)
Adverse Pharmacological Actions : Abortive : CK(2) : AC(1), Anti-Fertility : CK(6) : AC(1)

Children's growth and intelligence can be adversely affected by fluoride and arsenic exposure in drinking water.

Pubmed Data : Environ Health Perspect. 2007 Apr;115(4):643-7. Epub 2007 Jan 9. PMID: 17450237
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Children: Impaired Growth : CK(30) : AC(3), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12)
Problem Substances : Arsenic : CK(82) : AC(12), Fluoride : CK(264) : AC(45)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Chronic fluoride exposure has an important role in pathogenesis of coronary artery ectasia.

Pubmed Data : Biol Trace Elem Res. 2011 Nov ;143(2):695-701. Epub 2010 Dec 7. PMID: 21136197
Article Published Date : Nov 01, 2011
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Ecstasia : CK(10) : AC(1)
Problem Substances : Fluoride : CK(264) : AC(45), Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Dental fluorosis results from fluoride intake by different sources.

Pubmed Data : Gac Med Mex. 2009 Jul-Aug;145(4):263-7. PMID: 20073427
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Diseases : Fluorosis : CK(219) : AC(6)
Problem Substances : Fluoride : CK(264) : AC(45), Sodium Fluoride : CK(88) : AC(26), Sugary soda : CK(149) : AC(20)

Exposure to fluoride and arsenic in drinking water is associated with decreased intelligence in children.

Pubmed Data : Cad Saude Publica. 2007;23 Suppl 4:S579-87. PMID: 18038039
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12)
Problem Substances : Arsenic : CK(82) : AC(12), Fluoride : CK(264) : AC(45)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Fluoride deposits in the pineal gland with age and is associated with enhanced gland calcification.

Pubmed Data : Caries Res. 2001 Mar-Apr;35(2):125-8. PMID: 11275672
Article Published Date : Mar 01, 2001
Study Type : Human Study
Additional Links
Diseases : Ectopic Calcification : CK(792) : AC(113), Fluoride Toxicity : CK(146) : AC(40), Pineal Gland Calcification : CK(198) : AC(24), Pineal Gland Diseases : CK(10) : AC(1)
Problem Substances : Fluoride : CK(264) : AC(45)

Fluoridination of water contributes to elevated blood levels and other disorders in children.

Pubmed Data : Neurotoxicology. 2007 Sep;28(5):1032-42. Epub 2007 Mar 1. PMID: 17420053
Article Published Date : Sep 01, 2007
Study Type : Human Study
Additional Links
Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Lead Poisoning : CK(173) : AC(34)
Additional Keywords : Fluoride In The Water : CK(10) : AC(1)
Problem Substances : Fluoride : CK(264) : AC(45)

High iodine and high fluorine adversely effects the intelligence and health of children.

Pubmed Data : Zhonghua Liu Xing Bing Xue Za Zhi. 1994 Oct;15(5):296-8. PMID: 7859263
Article Published Date : Oct 01, 1994
Study Type : Human Study
Additional Links
Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), TSH: Elevated : CK(20) : AC(2)
Problem Substances : Fluoride : CK(264) : AC(45), Iodine: Excess : CK(10) : AC(1)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Infants fully formula-fed on formulae prepared with optimally fluoridated water (0.7-1.0 mg/L) have a high probability of exceeding the upper limit for fluoride and are at increased risk of dental fluorosis.

Pubmed Data : J Public Health Dent. 2010 Jun 2. Epub 2010 Jun 2. PMID: 20545827
Article Published Date : Jun 02, 2010
Study Type : Human Study
Additional Links
Diseases : Fluoride Toxicity : CK(146) : AC(40), Fluorosis : CK(219) : AC(6)
Problem Substances : Fluoride : CK(264) : AC(45), Infant Formula : CK(485) : AC(63), Public Drinking Water : CK(13) : AC(4)

There is an association of vascular fluoride uptake with vascular calcification and coronary artery disease.

Pubmed Data : Nucl Med Commun. 2012 Jan ;33(1):14-20. PMID: 21946616
Article Published Date : Jan 01, 2012
Study Type : Human Study
Additional Links
Diseases : Arterial Calcification : CK(154) : AC(25), Ectopic Calcification : CK(792) : AC(113), Vascular Calcification : CK(191) : AC(28)
Problem Substances : Sodium Fluoride : CK(88) : AC(26)

"Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss."

Pubmed Data : Toxicol Appl Pharmacol. 2008 Aug 1 ;230(3):352-7. Epub 2008 Mar 28. PMID: 18455746
Article Published Date : Jul 31, 2008
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male : CK(209) : AC(52), Oxidative Stress : CK(1945) : AC(710), Sperm Quality: Low : CK(162) : AC(28)
Problem Substances : Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Anti-Fertility : CK(6) : AC(1), Oxidant : CK(104) : AC(37)

Amla exhibits antihyperglycemic and hepato-renal protective properties in fluoride induced toxicity.

Pubmed Data : J Pharm Bioallied Sci. 2012 Jul ;4(3):250-4. PMID: 22923969
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Amla Fruit : CK(51) : AC(28)
Diseases : Fluoride Toxicity : CK(146) : AC(40)
Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Hypoglycemic Agents : CK(563) : AC(156), Renoprotective : CK(191) : AC(90)
Problem Substances : Fluoride : CK(264) : AC(45)

Chronic fluoride exposure is associated with myocardial damage which is attenuated with selenium and vitamin E.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Int. 2011 Jul ;18(2):99-104. PMID: 21976813
Article Published Date : Jul 01, 2011
Study Type : Animal Study
Additional Links
Substances : Selenium : CK(574) : AC(94), Vitamin E : CK(1285) : AC(221)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)
Problem Substances : Fluoride : CK(264) : AC(45)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Curcumin showed significant nephroprotective effects against Sodium Fluoride induced toxicity upon kidneys.

Pubmed Data : Biol Trace Elem Res. 2012 Mar ;145(3):369-74. Epub 2011 Sep 7. PMID: 21901432
Article Published Date : Mar 01, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Vitamin C : CK(1274) : AC(238)
Diseases : Fluoride Toxicity : CK(146) : AC(40)
Additional Keywords : Antioxidant : CK(12) : AC(2)
Problem Substances : Sodium Fluoride : CK(88) : AC(26)

Female reproductive function is inhibited by NaF and that exposure to NaF causes ovarian and uterine structural damage.

Pubmed Data : Food Chem Toxicol. 2013 Feb 28. Epub 2013 Feb 28. PMID: 23459146
Article Published Date : Feb 27, 2013
Study Type : Animal Study
Additional Links
Diseases : Infertility: Female : CK(182) : AC(33), Ovarian Diseases : CK(11) : AC(6), Uterine Diseases : CK(512) : AC(95)
Problem Substances : Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Anti-Fertility : CK(6) : AC(1)

Fertility impairment in mice on a low fluoride intake has been observed.

Pubmed Data : Science. 1972 Sep 8 ;177(4052):893-4. PMID: 5054644
Article Published Date : Sep 07, 1972
Study Type : Animal Study
Additional Links
Diseases : Infertility: Female : CK(182) : AC(33)
Problem Substances : Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Anti-Fertility : CK(6) : AC(1)

Flouride increases lead concentrations in whole blood and in calcified tissues from lead-exposed rats.

Pubmed Data : Toxicology. 2010 Feb 25. Epub 2010 Feb 25. PMID: 20188782
Article Published Date : Feb 25, 2010
Study Type : Animal Study
Additional Links
Diseases : Lead Poisoning : CK(173) : AC(34)
Problem Substances : Fluoride : CK(264) : AC(45), Lead : CK(97) : AC(15)

Fluoride and arsenic exhibit cardiotoxic properties related to their pro-inflammatory effect.

Pubmed Data : Arch Toxicol. 2012 Mar 16. Epub 2012 Mar 16. PMID: 22422340
Article Published Date : Mar 16, 2012
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641)
Problem Substances : Arsenic : CK(82) : AC(12), Fluoride : CK(264) : AC(45)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Inflammatory : CK(150) : AC(37), Interleukin-6 up-regulation : CK(14) : AC(3), Interleukin-8 up-regulation : CK(2) : AC(1), MCP-1 (CCL2) up-regulation : CK(2) : AC(1), P-selectin upregulation : CK(2) : AC(1), Vascular Cell Adhesion Molecule-1 (VCAM-1) Up-Regulation : CK(2) : AC(1)

Fluoride exposure over several generations results in adverse histopathological and biochemical changes in lung tissue.

Pubmed Data : J Appl Toxicol. 2003 Nov-Dec;23(6):437-46. PMID: 14635268
Article Published Date : Nov 01, 2003
Study Type : Animal Study
Additional Links
Diseases : Fluoride Toxicity : CK(146) : AC(40)
Problem Substances : Fluoride : CK(264) : AC(45), Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Teratogenic : CK(304) : AC(59)

Related Blogs

Can Fluoride Lower Human Intelligence?
Written by Sayer Ji, Founder
If those who believe that fluoride doesn’t “make you stupid” (i.e. lower IQ) let themselves be exposed to it, or willfully consume it for its “health benefits,” doesn’t that prove the point? Could their fluoride-exposed brains and bodies lack the discernment needed to ascertain the dangers of such exposure?
Fertility Destroying Chemical Added To Tap, Milk, Salt
Written by Sayer Ji, Founder
Government and industry health authorities often talk about this 'therapeutic' chemical as being more important than good nutrition in preventing cavities, but ingesting it can lead to serious health problems
Fluoride in your Drinking Water Making You LOOK Older?
Written by Anne Gordon, RN
Fluoride in your Drinking Water Making You LOOK Older? In the 1950' a TV commercial convinced people that fluoride was outstanding for teeth. By brushing, yellow teeth would become white, and cavities would be eradicated. Dentists concurred and encouraged the use of fluoride. So, through clever marketing, it became an urban belief that fluoride in toothpaste would be fabulous for strong healthy cavity free white teeth.

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