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Article Count - 15
Cumulative Knowledge - 75

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Quick Summary: Current access displays 2 out of 24 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Chemically-Induced Liver Damage	30	3	Log in \| Sign up
Statin-Induced Pathologies	30	6	Log in \| Sign up

Quick Summary: Current access displays 2 out of 5 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Hepatotoxic	23	3	Log in \| Sign up
Oxidant	10	1	Log in \| Sign up

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View the Evidence: Problem Substances

Fluvastatin has been linked to adverse hepatic reactions.

Click here to read the entire abstract

Pubmed Data : Drug Saf. 2006 ;29(12):1163-72. PMID: 17147462

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)

Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Liver failure and damage are rare but severe unintended consequences of statin drug use.

Click here to read the entire abstract

Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469

Article Published Date : Aug 31, 2011

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Damage : CK(597) : AC(213), Liver Disease : CK(112) : AC(31), Liver Failure: Drug Induced : CK(23) : AC(3), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Statin drugs alter platelet function.

Click here to read the entire abstract

Pubmed Data : Eur J Clin Invest. 2002 Dec ;32(12):901-8. PMID: 12534449

Article Published Date : Dec 01, 2002

Study Type : Human Study

Additional Links

Diseases : Blood Platelet Disorders : CK(20) : AC(2)

Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)

Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Statin therapy appears to be associated with increased oxidation injury.

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Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128

Article Published Date : Jan 01, 2002

Study Type : Human Study

Additional Links

Diseases : Oxidative Stress : CK(1945) : AC(710)

Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.

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Pubmed Data : BMJ. 2010;340:c2197. Epub 2010 May 20. PMID: 20488911

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Cataract : CK(182) : AC(55), Chemically-Induced Liver Damage : CK(475) : AC(175), Esophageal Cancer : CK(328) : AC(55), Kidney Failure : CK(668) : AC(41), Myopathies : CK(252) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Pravastatin : CK(239) : AC(40), Rosuvastatin : CK(68) : AC(16), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Acute pancreatitis induced by fluvastatin therapy has been reported.

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Pubmed Data : J Clin Gastroenterol. 2002 Nov-Dec;35(5):406-8. PMID: 12394230

Article Published Date : Nov 01, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Pancreatitis : CK(164) : AC(40), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)

Autoimmune hepatitis after treatment with fluvastatin has been reported.

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Pubmed Data : Liver Int. 2007 May ;27(4):592. PMID: 17403199

Article Published Date : May 01, 2007

Study Type : Human: Case Report

Additional Links

Diseases : Hepatitis: Autoimmune : CK(41) : AC(8)

Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Immunotoxic : CK(230) : AC(38)

Fatal lupus-like syndrome and ARDS induced by fluvastatin has been reported.

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Pubmed Data : Lancet. 1998 Jul 11 ;352(9122):114. PMID: 9672281

Article Published Date : Jul 11, 1998

Study Type : Human: Case Report

Additional Links

Diseases : Acute Respiratory Distress Syndrome : CK(15) : AC(3), Lupus-Like Syndrome : CK(29) : AC(5)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Fluvastatin : CK(75) : AC(15)

Fluvastatin use may be a cause of autoimmune hepatitis.

Click here to read the entire abstract

Pubmed Data : Indian J Gastroenterol. 2011 Mar ;30(2):97-9. Epub 2011 Apr 19. PMID: 21503830

Article Published Date : Mar 01, 2011

Study Type : Human: Case Report

Additional Links

Diseases : Hepatitis : CK(64) : AC(23)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Fluvastatin : CK(75) : AC(15)

Fluvastatin-induced dermatomyositis has been reported.

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Pubmed Data : Ann Dermatol Venereol. 2005 Dec ;132(12 Pt 1):996-9. PMID: 16446645

Article Published Date : Dec 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Dermatomyositis : CK(44) : AC(10)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Fluvastatin : CK(75) : AC(15)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Lichenoid drug eruption with fluvastatin and lovastatin has been reported.

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Pubmed Data : Acta Derm Venereol. 2004 ;84(3):229-30. PMID: 15202842

Article Published Date : Jan 01, 2004

Study Type : Human: Case Report

Additional Links

Diseases : Lichenoid Dermatitis : CK(12) : AC(4), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Fluvastatin : CK(75) : AC(15), Lovastatin : CK(265) : AC(67)

Lipophilic statin drugs are associated with impaired skeletal muscle mitochondria.

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Pubmed Data : Cell Mol Life Sci. 2006 Oct;63(19-20):2415-25. PMID: 17013560

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Diseases : Mitochondrial Myopathies : CK(46) : AC(9), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Cerivastatin : CK(10) : AC(4), Fluvastatin : CK(75) : AC(15), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Lipophilic statin drugs worsen myocardial ischemia in dogs.

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Pubmed Data : J Cardiovasc Pharmacol. 2000 Feb ;35(2):256-62. PMID: 10672858

Article Published Date : Feb 01, 2000

Study Type : Animal Study

Additional Links

Diseases : Myocardial Ischemia : CK(87) : AC(37)

Additional Keywords : Lipophilic Stains : CK(2) : AC(1)

Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Statin administration in animals results in a myopathy characterized by decreased muscle force and elevated plasma CK level.

Click here to read the entire abstract

Pubmed Data : J Muscle Res Cell Motil. 2011 Nov 9. Epub 2011 Nov 9. PMID: 22068225

Article Published Date : Nov 09, 2011

Study Type : Animal Study

Additional Links

Diseases : Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9), Myalgias : CK(105) : AC(14), Myopathies : CK(252) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Statin drugs may induce their toxic effects through inhibition of Rab1 GTPase and endoplasmic reticulum-to-Golgi trafficking.

Click here to read the entire abstract

Pubmed Data : J Pharmacol Exp Ther. 2011 Apr 5. Epub 2011 Apr 5. PMID: 21467191

Article Published Date : Apr 05, 2011

Study Type : In Vitro Study

Additional Links

Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)

Health Guide: Statin Drugs

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