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Article Count - 17
Cumulative Knowledge - 55

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Quick Summary: Current access displays 2 out of 20 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Diabetes Mellitus: Type 1: Prevention	20	1	Log in \| Sign up
Schizophrenia	12	2	Log in \| Sign up

Quick Summary: 2 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Endocrine Disruptor	2	1	Log in \| Sign up
Endocrine Disruptor: Pancreas	2	1	Log in \| Sign up

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View the Evidence: Problem Substances

The beta-casein A1 protein variant of cow's milk may contribute to increased risk of diabetes type 1.

Click here to read the entire abstract

Pubmed Data : Diabetologia. 1999 Mar;42(3):292-6. PMID: 10096780

Article Published Date : Mar 01, 1999

Study Type : Meta Analysis

Additional Links

Diseases : Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16)

Schizophrenia prevalence is correlated with gluten grain consumption.

Click here to read the entire abstract

Pubmed Data : Biol Psychiatry. 1984 Mar;19(3):385-99. PMID: 6609726

Article Published Date : Mar 01, 1984

Study Type : Human Study

Additional Links

Diseases : Gluten Intolerance : CK(236) : AC(33), Schizophrenia : CK(247) : AC(29)

Problem Substances : Gluten : CK(1755) : AC(144), Gluten exorphins : CK(26) : AC(11)

Bioactive peptides in digesta that regulate gastrointestinal function and intake.

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Pubmed Data : J Anim Sci. 1996 Oct ;74(10):2500-8. PMID: 8904720

Article Published Date : Oct 01, 1996

Study Type : Animal Study

Additional Links

Problem Substances : Casomorphins : CK(26) : AC(6)

Gastrointestinal proteases break down wheat gluten resulting in the release of opioid peptides.

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Pubmed Data : FEBS Lett. 1997 Aug 4;412(3):475-9. PMID: 9276449

Article Published Date : Aug 04, 1997

Study Type : Animal Study

Additional Links

Additional Keywords : Opioid-Like Activity : CK(5) : AC(4)

Problem Substances : Gluten : CK(1755) : AC(144), Gluten exorphins : CK(26) : AC(11), Wheat : CK(2542) : AC(309)

Gliadorphin-7 and beta-casomorphin-7 are pharmacologically active food peptides.

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Pubmed Data : Peptides. 2003 Feb;24(2):321-3. PMID: 12668219

Article Published Date : Feb 01, 2003

Study Type : Animal Study

Additional Links

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Gliadin : CK(2509) : AC(110), Gluten exorphins : CK(26) : AC(11)

Gluten exorphin modulate pancreatic endocrine function by stimulating insulin release.

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Pubmed Data : Life Sci. 1995;57(7):729-34. PMID: 7637543

Article Published Date : Jan 01, 1995

Study Type : Animal Study

Additional Links

Diseases : Insulin: Elevated : CK(186) : AC(41), Insulin Disorders : CK(15) : AC(4)

Problem Substances : Gluten exorphins : CK(26) : AC(11)

Adverse Pharmacological Actions : Endocrine Disruptor: Pancreas : CK(4) : AC(2)

Gluten exorphins alter serum prolactin levels in male rats.

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Pubmed Data : Nutr Neurosci. 2004 Feb;7(1):53-5. PMID: 15085559

Article Published Date : Feb 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Male Hormone Imbalances : CK(14) : AC(3), Prolactin: Inappropriate Secretion : CK(4) : AC(1)

Additional Keywords : Food Drugs : CK(4) : AC(2)

Problem Substances : Gluten : CK(1755) : AC(144), Gluten exorphins : CK(26) : AC(11)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Intravenous administration of the food-derived opioid peptide gluten exorphin B5 stimulates prolactin secretion in rats.

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Pubmed Data : Pharmacol Res. 2003 Jan ;47(1):53-8. PMID: 12526862

Article Published Date : Jan 01, 2003

Study Type : Animal Study

Additional Links

Diseases : Prolactin: Inappropriate Secretion : CK(4) : AC(1), Prolactin Hypersecretion Syndrome : CK(4) : AC(2)

Problem Substances : Gluten : CK(1755) : AC(144), Gluten exorphins : CK(26) : AC(11)

Opioid peptides derived from wheat gluten has an effect on pituitary function when administered intraperitoneally.

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Pubmed Data : Life Sci. 2002 Oct 4;71(20):2383-90. PMID: 12231399

Article Published Date : Oct 04, 2002

Study Type : Animal Study

Additional Links

Diseases : Pituitary Diseases : CK(3) : AC(2)

Problem Substances : Gluten : CK(1755) : AC(144), Gluten exorphins : CK(26) : AC(11), Wheat : CK(2542) : AC(309)

Beta casein A1 and B yields beta-casomophin 7 (BCM-7), a potentially harmful peptide.

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Pubmed Data : J Appl Genet. 2007;48(3):189-98. PMID: 17666771

Article Published Date : Jan 01, 2007

Study Type : Review

Additional Links

Diseases : Allergy: Cow's Milk : CK(92) : AC(18)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7)

Beta-casomorphin may contribute to apnea in sudden infant death syndrome.

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Pubmed Data : Peptides. 2003 Jun;24(6):937-43. PMID: 12948848

Article Published Date : Jun 01, 2003

Study Type : Commentary

Additional Links

Diseases : Apnea : CK(69) : AC(11), Sudden Infant Death Syndrome (SIDS) : CK(138) : AC(18)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7)

Cow's milk (A1) may stimulate mucus production associated with respiratory conditions such as asthma.

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 2010 Apr;74(4):732-4. Epub 2009 Nov 25. PMID: 19932941

Article Published Date : Apr 01, 2010

Study Type : Commentary

Additional Links

Diseases : Allergy: Cow's Milk : CK(92) : AC(18), Asthma : CK(918) : AC(134), Milk Intolerance : CK(56) : AC(2), Respiratory Diseases : CK(174) : AC(29)

Additional Keywords : A1 Milk : CK(1) : AC(1), Beta-Casomorphin-7 : CK(1) : AC(1), Exorphin : CK(2) : AC(2)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Cow Milk : CK(368) : AC(46)

Opioid peptides derived from milk might be one of the etiological factors for sudden infant death syndrome and near miss sudden infant death syndrome.

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Pubmed Data : Med Hypotheses. 1988 Nov;27(3):181-7. PMID: 3062337

Article Published Date : Nov 01, 1988

Study Type : Commentary

Additional Links

Diseases : Sudden Infant Death Syndrome (SIDS) : CK(138) : AC(18)

Problem Substances : Beta-casomorphin-7 : CK(26) : AC(6), Casein : CK(135) : AC(16), Casein: A1 : CK(44) : AC(7), Cow Milk : CK(368) : AC(46)

There may be a schizophrenia-specific, genetically enhanced affinity for exorphins by opioid receptors influencing dopaminergic and other neurons.

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Pubmed Data : Schizophr Bull. 1988 ;14(4):489-94. PMID: 2851166

Article Published Date : Jan 01, 1988

Study Type : Commentary

Additional Links

Diseases : Schizophrenia : CK(247) : AC(29)

Additional Keywords : Food Opioids : CK(20) : AC(14)

Problem Substances : Casomorphins : CK(26) : AC(6), Gluten exorphins : CK(26) : AC(11)

Wheat gluten contains a novel opioid peptide named gluten exorphin C.

Click here to read the entire abstract

Pubmed Data : FEBS Lett. 1993 Jan 18;316(1):17-9. PMID: 8422933

Article Published Date : Jan 18, 1993

Study Type : In Vitro Study

Additional Links

Additional Keywords : Opioid-Like Activity : CK(5) : AC(4)

Problem Substances : Gluten : CK(1755) : AC(144), Gluten exorphins : CK(26) : AC(11), Wheat : CK(2542) : AC(309)

Wheat gluten contains opioid peptides.

Click here to read the entire abstract

Pubmed Data : FEBS Lett. 1992 Jan 13;296(1):107-11. PMID: 1309704

Article Published Date : Jan 13, 1992

Study Type : In Vitro Study

Additional Links

Diseases : Opiate Addiction/Withdrawal : CK(64) : AC(14)

Additional Keywords : Food Drugs : CK(4) : AC(2), Opioid-Like Activity : CK(5) : AC(4)

Problem Substances : Gluten : CK(1755) : AC(144), Gluten exorphins : CK(26) : AC(11), Wheat : CK(2542) : AC(309)

Wheat, rye, and barley proteins may act as aids to carcinogens.

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 1997 Sep;49(3):285-8. PMID: 9293475

Article Published Date : Sep 01, 1997

Study Type : Commentary

Additional Links

Diseases : Celiac Disease : CK(1527) : AC(215), HPA Axis Dysregulation : CK(71) : AC(11), Intestinal Permeability : CK(224) : AC(53), Lymphoma : CK(209) : AC(69)

Problem Substances : Barley : CK(13) : AC(3), Gluten exorphins : CK(26) : AC(11), Grains : CK(27) : AC(8), Rye : CK(12) : AC(3), Wheat : CK(2542) : AC(309)

Related Blogs

Do Hidden Opiates In Our Food Explain Food Addictions?

Written by Sayer Ji, Founder

Food addictions are not strictly “psychological” problems, but have a hard-wired, organic component. Many of the most commonly consumed foods in Western culture actually contain narcotic properties associated with the presence of psychoactive chemicals that bind to opioid receptors in the nervous system.

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