Histamine Receptor Antagonists

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View the Evidence: Problem Substances

Acid-suppressing drug use substantially increased the likelihood of recurrent pneumonia in high-risk elderly patients.

Pubmed Data : Am J Med. 2010 Jan;123(1):47-53. PMID: 20102991
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Elderly: Age Specific Diseases : CK(442) : AC(37), Pneumonia : CK(330) : AC(40)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Current use of gastric acid-suppressive therapy was associated with an increased risk of community-acquired pneumonia.

Pubmed Data : JAMA. 2004 Oct 27;292(16):1955-60. PMID: 15507580
Article Published Date : Oct 27, 2004
Study Type : Human Study
Additional Links
Diseases : Pneumonia : CK(330) : AC(40)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Increasing levels of pharmacologic acid suppression are associated with increased risks of nosocomial C difficile infection.

Pubmed Data : Arch Intern Med. 2010 May 10;170(9):784-90. PMID: 20458086
Article Published Date : May 10, 2010
Study Type : Human Study
Additional Links
Diseases : Bacterial Infections and Mycoses : CK(127) : AC(51), Clostridium Infections : CK(171) : AC(29)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Patients in hospital who received proton pump inhibitors were at increased risk of Clostridium difficile diarrhea.

Pubmed Data : CMAJ. 2004 Jul 6;171(1):33-8. PMID: 15238493
Article Published Date : Jul 06, 2004
Study Type : Human Study
Additional Links
Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.

Pubmed Data : Gastroenterology. 2010 Jul;139(1):93-101. Epub 2010 Mar 27. PMID: 20353792
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acid Reflux : CK(288) : AC(42), Gastroesophageal Reflux : CK(278) : AC(41), Osteoporosis : CK(1171) : AC(205)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12)

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12

Pubmed Data : Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642
Article Published Date : Apr 01, 1983
Study Type : Human Study
Additional Links
Substances : Vitamin B-12 : CK(752) : AC(94)
Diseases : Acid Reflux : CK(288) : AC(42), Drug-Induced Nutrient Depletion: Vitamin B-12 : CK(20) : AC(2), Vitamin B 12 Deficiency : CK(220) : AC(34)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Ranitidine : CK(10) : AC(1)

The use of acid-suppressive therapy, particularly proton pump inhibitors, and NSAIDs are associated with an increased risk of community-acquired C difficile.

Pubmed Data : JAMA. 2005 Dec 21;294(23):2989-95. PMID: 16414946
Article Published Date : Dec 21, 2005
Study Type : Human Study
Additional Links
Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72), Low Immune Function: Natural Killer Cells : CK(108) : AC(21)
Problem Substances : Antacids: Aluminium-Containing : CK(22) : AC(3), Histamine Receptor Antagonists : CK(97) : AC(12), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.

Pubmed Data : Pediatrics. 2006 May;117(5):e817-20. PMID: 16651285
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Diseases : Childhood Infections : CK(275) : AC(29), Gastroenteritis : CK(96) : AC(11), Infection: In Infants & Children : CK(111) : AC(11), Pneumonia : CK(330) : AC(40)
Additional Keywords : Drug: Omeprazole : CK(90) : AC(15)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Acid blockers (H2 receptor blockers) have anti-ovulatory activity in rabbits.

Pubmed Data : Eur J Contracept Reprod Health Care. 2011 Apr;16(2):142-6. Epub 2011 Jan 31. PMID: 21281096
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Gastroesophageal Reflux : CK(278) : AC(41), Infertility: Female : CK(182) : AC(33)
Problem Substances : Acid Blockers : CK(244) : AC(31), Histamine Receptor Antagonists : CK(97) : AC(12)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Histamine receptor antagonists and proton pump inhibitors cause gastric hyperplasia and cancer in rats.

Pubmed Data : Toxicol Pathol. 1988;16(2):288-98. PMID: 2903544
Article Published Date : Jan 01, 1988
Study Type : Animal Study
Additional Links
Diseases : Gastric Cancer : CK(373) : AC(111)
Additional Keywords : Drug: Omeprazole : CK(90) : AC(15)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Omeprazole (trade name Prisolec) : CK(46) : AC(7), Proton-Pump Inhibitors : CK(218) : AC(27)

Long-acting inhibitors of gastric acid secretion may result in endocrine cell hyperplasia and cancer in the gastric mucosa.

Pubmed Data : Eur J Clin Invest. 1990 Oct;20 Suppl 1:S65-71. PMID: 2125000
Article Published Date : Oct 01, 1990
Study Type : Animal Study
Additional Links
Diseases : Gastric Cancer : CK(373) : AC(111)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

There are a number of risks associated with long-term acid blocking treatment.

Pubmed Data : Vnitr Lek. 2010 Feb;56(2):115-9. PMID: 20329581
Article Published Date : Feb 01, 2010
Study Type : Commentary
Additional Links
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12)

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