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Ibuprofen

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Article Count - 19
Cumulative Knowledge - 162

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Name	Cumulative Knowledge	Article Count	Focus Articles
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Hypertensive	10	1	Log in \| Sign up

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View the Evidence: Problem Substances

Nonsteroidal antinflammatory drugs increase cardiovascular events in patients after hospitalization for serious coronary heart disease.

Click here to read the entire abstract

Pubmed Data : Circ Cardiovasc Qual Outcomes. 2009 May;2(3):155-63. Epub 2009 May 5. PMID: 20031832

Article Published Date : May 01, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)

Problem Substances : Celecoxib : CK(50) : AC(4), Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Rofecoxib : CK(60) : AC(5)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.

Click here to read the entire abstract

Pubmed Data : Am J Med. 2010 Mar;123(3):231-7. PMID: 20193831

Article Published Date : Mar 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Hearing Loss : CK(97) : AC(24)

Problem Substances : Aspirin : CK(471) : AC(64), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Tylenol : CK(125) : AC(13)

A case of pulmonary hypertension following L-lysine ibuprofen therapy has been reported in a preterm infant with patent ductus arteriosus.

Click here to read the entire abstract

Pubmed Data : CMAJ. 2006 Jun 20;174(13):1843-4. PMID: 16785458

Article Published Date : Jun 20, 2006

Study Type : Human Study

Additional Links

Diseases : Hypertension: Pulmonary : CK(1830) : AC(34), Premature Birth : CK(412) : AC(43), Preterm Infants: Patent Ductus Arteriosus (PDA) : CK(20) : AC(2)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9)

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.

Click here to read the entire abstract

Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Children: Drug-Induced Toxicity : CK(10) : AC(1)

Problem Substances : Diclofenac : CK(72) : AC(7), Dipyrone : CK(10) : AC(1), Ibuprofen : CK(162) : AC(19), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Paracetamol : CK(44) : AC(6)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.

Click here to read the entire abstract

Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Febrile Seizures : CK(83) : AC(5), Fever : CK(77) : AC(14)

Problem Substances : Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Paracetamol : CK(44) : AC(6), Tylenol : CK(125) : AC(13)

Ibuprofen has mildly hypertensive properties.

Click here to read the entire abstract

Pubmed Data : J Hypertens. 2008 Aug;26(8):1695-702. PMID: 18622250

Article Published Date : Aug 01, 2008

Study Type : Human Study

Additional Links

Diseases : Hypertension : CK(2783) : AC(271)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Ibuprofen use is associated wtih increased mortality.

Click here to read the entire abstract

Pubmed Data : Am J Ther. 2004 May-Jun;11(3):156-63. PMID: 15133529

Article Published Date : May 01, 2004

Study Type : Human Study

Additional Links

Diseases : Mortality: All-Cause : CK(644) : AC(55)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Ibuprofen use may increase the risk of thrombotic and congestive heart failure events.

Click here to read the entire abstract

Pubmed Data : Ann Rheum Dis. 2007 Jun;66(6):764-70. Epub 2007 Apr 5. PMID: 17412741

Article Published Date : Jun 01, 2007

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Congestive Heart Failure : CK(256) : AC(33), Heart Attack : CK(2598) : AC(117), Heart Failure : CK(711) : AC(97), Thrombosis : CK(657) : AC(74)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

NSAIDs are associated with an increased risk of myocardial infarction and death.

Click here to read the entire abstract

Pubmed Data : Clin Pharmacol Ther. 2009 Feb;85(2):190-7. Epub 2008 Nov 5. PMID: 18987620

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Myocardial Infarction : CK(2632) : AC(117)

Problem Substances : Celecoxib : CK(50) : AC(4), Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Rofecoxib : CK(60) : AC(5)

NSAIDs are frequently used in patients with heart failure and are associated with increased risk of death and cardiovascular morbidity.

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2009 Jan 26;169(2):141-9. PMID: 19171810

Article Published Date : Jan 26, 2009

Study Type : Human Study

Additional Links

Diseases : Heart Failure : CK(711) : AC(97), Myocardial Infarction : CK(2632) : AC(117)

Problem Substances : Celecoxib : CK(50) : AC(4), Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Rofecoxib : CK(60) : AC(5)

Patients taking aspirin plus ibuprofen have an increased risk of all-cause mortality.

Click here to read the entire abstract

Pubmed Data : Lancet. 2003 Feb 15;361(9357):573-4. PMID: 12598144

Article Published Date : Feb 15, 2003

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Mortality: All-Cause : CK(644) : AC(55)

Problem Substances : Aspirin : CK(471) : AC(64), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Taking non-aspirin NSAIDs in early pregnancy doubles the risk of miscarriage.

Click here to read the entire abstract

Pubmed Data : BMJ. 2011 ;343:d5769. Epub 2011 Sep 9. PMID: 21908536

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous : CK(204) : AC(29), Drug-Induced Toxicity : CK(560) : AC(78), Miscarriage : CK(507) : AC(35)

Pharmacological Actions : Teratogens : CK(10) : AC(1)

Problem Substances : Celecoxib : CK(50) : AC(4), Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Rofecoxib : CK(60) : AC(5)

Adverse Pharmacological Actions : Teratogenic : CK(304) : AC(59)

The use of ibuprofen in preterm infants with PDA increases the risk of chronic lung disease by 30%.

Click here to read the entire abstract

Pubmed Data : Arch Dis Child Fetal Neonatal Ed. 2010 Sep 27. Epub 2010 Sep 27. PMID: 20876595

Article Published Date : Sep 27, 2010

Study Type : Human Study

Additional Links

Diseases : Childhood Chronic Lung Diseases : CK(40) : AC(4), Preterm Infant Care : CK(121) : AC(12)

Problem Substances : Ibuprofen : CK(162) : AC(19)

Ibuprofen has been reported to cause cardiac arrhythmia.

Click here to read the entire abstract

Pubmed Data : J Med Case Reports. 2010;4:76. Epub 2010 Mar 2. PMID: 20193088

Article Published Date : Jan 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Arrhythmias: Cardiac : CK(451) : AC(63)

Problem Substances : Ibuprofen : CK(162) : AC(19)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Antipyretics increase influenza-associated mortality.

Click here to read the entire abstract

Pubmed Data : J R Soc Med. 2010 Oct;103(10):403-11. PMID: 20929891

Article Published Date : Oct 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Aspirin-Induced Toxicity : CK(83) : AC(24), Influenza : CK(654) : AC(102), Influenza: Mortality : CK(2) : AC(1)

Problem Substances : Aspirin : CK(471) : AC(64), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Ibuprofen augments pro-inflammatory cytokine release and increases mortality in a mouse model of Vibrio vulnificus infection.

Click here to read the entire abstract

Pubmed Data : Microbiol Immunol. 2010 Sep;54(9):542-50. PMID: 20840153

Article Published Date : Sep 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Vibrio Infections : CK(13) : AC(12)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Ibuprofen has a genotoxic affect in mouse bone marrow cells.

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2012 Jan 27. Epub 2012 Jan 27. PMID: 22283434

Article Published Date : Jan 27, 2012

Study Type : Animal Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Ibuprofen : CK(162) : AC(19)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Ibuprofen increased the mortality significantly in the GAS-infected mice.

Click here to read the entire abstract

Pubmed Data : J Microbiol Immunol Infect. 2011 Dec ;44(6):418-23. Epub 2011 Jun 22. PMID: 21697021

Article Published Date : Dec 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Ibuprofen Toxicity : CK(2) : AC(1), Streptococcus infections: Group A : CK(10) : AC(6)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Non-steroidal anti-inflammatory drugs exhibit direct cytotoxicity against erthyrocytes (red blood cells) in vitro in an acidic media.

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2002 Dec;57(12):848-51. PMID: 12561250

Article Published Date : Dec 01, 2002

Study Type : In Vitro Study

Additional Links

Diseases : Anemia : CK(89) : AC(12)

Problem Substances : Aspirin : CK(471) : AC(64), Ibuprofen : CK(162) : AC(19), Indomethacin : CK(13) : AC(2), Meloxicam : CK(1) : AC(1), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Paracetamol : CK(44) : AC(6)

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