Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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Quick Summary: Current access displays 2 out of 100 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Cardiovascular Diseases	231	11	Log in \| Sign up
Cardiac Mortality	220	10	Log in \| Sign up

Quick Summary: Current access displays 2 out of 16 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Cardiotoxic	186	10	Log in \| Sign up
Ulcerogenic	60	3	Log in \| Sign up

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View the Evidence: Problem Substances

Aspirin does not prevent cardiovascular events in diabetes mellitus.

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Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671

Article Published Date : Jun 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Cardiovascular Diseases : CK(5007) : AC(648), Diabetes: Cardiovascular Illness : CK(654) : AC(104), Diabetes Mellitus: Type 2 : CK(3142) : AC(328)

Problem Substances : Aspirin : CK(424) : AC(56)

long-term, low-dose aspirin treatment has little effect on the prevention of venous thromboembolism in initially healthy women.

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Pubmed Data : Ann Intern Med. 2007 Oct 16;147(8):525-33. PMID: 17938390

Article Published Date : Oct 16, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Thromboembolism : CK(247) : AC(19)

Problem Substances : Aspirin : CK(424) : AC(56)

Nonsteroidal antinflammatory drugs increase cardiovascular events in patients after hospitalization for serious coronary heart disease.

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Pubmed Data : Circ Cardiovasc Qual Outcomes. 2009 May;2(3):155-63. Epub 2009 May 5. PMID: 20031832

Article Published Date : May 01, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Cardiac Mortality : CK(713) : AC(67), Cardiovascular Diseases : CK(5007) : AC(648), Coronary Artery Disease : CK(1303) : AC(136), Myocardial Infarction : CK(2598) : AC(117)

Problem Substances : Celecoxib : CK(50) : AC(4), Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105), Rofecoxib : CK(60) : AC(5)

Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74)

NSAIDs may contribute to necrotising fascilitis and dermal linfections.

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Pubmed Data : Prescrire Int. 2007 Feb ;16(87):17. PMID: 17323524

Article Published Date : Feb 01, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Fasciitis: Necrotizing : CK(22) : AC(2), Skin Infections : CK(21) : AC(1)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105)

Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.

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Pubmed Data : J Am Coll Cardiol. 2010 Oct 19;56(17):1376-85. PMID: 20946994

Article Published Date : Oct 19, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Coronary Artery Disease : CK(1303) : AC(136), Myocardial Infarction : CK(2598) : AC(117)

Problem Substances : Aspirin : CK(424) : AC(56)

Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74)

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.

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Pubmed Data : Am J Med. 2010 Mar;123(3):231-7. PMID: 20193831

Article Published Date : Mar 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Drug-Induced Toxicity : CK(538) : AC(78), Hearing Loss : CK(97) : AC(24)

Problem Substances : Aspirin : CK(424) : AC(56), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105), Tylenol : CK(125) : AC(13)

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.

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Pubmed Data : Cochrane Database Syst Rev. 2002(2):CD003676. PMID: 12076499

Article Published Date : Jan 01, 2002

Study Type : Meta Analysis

Additional Links

Diseases : Fever : CK(77) : AC(14)

Problem Substances : Paracetamol : CK(42) : AC(5), Tylenol : CK(125) : AC(13)

A case of pulmonary hypertension following L-lysine ibuprofen therapy has been reported in a preterm infant with patent ductus arteriosus.

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Pubmed Data : CMAJ. 2006 Jun 20;174(13):1843-4. PMID: 16785458

Article Published Date : Jun 20, 2006

Study Type : Human Study

Additional Links

Diseases : Hypertension: Pulmonary : CK(1830) : AC(34), Premature Birth : CK(412) : AC(43), Preterm Infants: Patent Ductus Arteriosus (PDA) : CK(20) : AC(2)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105)

Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9)

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe.

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Pubmed Data : Transfus Med Rev. 2007 Jan;21(1):1-12. PMID: 17174216

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(96) : AC(26), Blood Transfusion : CK(60) : AC(4)

Problem Substances : Diphenhydramine : CK(72) : AC(9), Tylenol : CK(125) : AC(13)

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.

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Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737

Article Published Date : May 01, 2008

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(96) : AC(26), Autism Spectrum Disorders : CK(1118) : AC(108)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105), Tylenol : CK(125) : AC(13)

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.

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Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Children: Drug-Induced Toxicity : CK(10) : AC(1)

Problem Substances : Diclofenac : CK(72) : AC(7), Dipyrone : CK(10) : AC(1), Ibuprofen : CK(162) : AC(19), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105), Paracetamol : CK(42) : AC(5)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Alendronate and naproxen are synergistic for development of gastric ulcers.

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Pubmed Data : Arch Intern Med. 2001 Jan 8;161(1):107-10. PMID: 11146706

Article Published Date : Jan 08, 2001

Study Type : Human Study

Additional Links

Diseases : Duodenal Ulcer : CK(99) : AC(27), Gastric Ulcer : CK(254) : AC(97)

Additional Keywords : Toxic Drug Synergy : CK(10) : AC(1)

Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105)

Adverse Pharmacological Actions : Ulcerogenic : CK(66) : AC(9)

Alendronate is associated with injury and ulceration of the gastric mucosa.

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Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity: Gastrointestinal : CK(21) : AC(3), Gastric Ulcer : CK(254) : AC(97), Osteoporosis : CK(1090) : AC(205)

Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Aspirin : CK(424) : AC(56), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1212) : AC(105)

Adverse Pharmacological Actions : Gastrotoxic : CK(20) : AC(2), Ulcerogenic : CK(66) : AC(9)

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