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Organochlorine compounds

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Article Count - 13
Cumulative Knowledge - 105

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Quick Summary: Current access displays 2 out of 18 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Hypothyroidism	31	4	Log in \| Sign up
Pesticide Toxicity	22	3	Log in \| Sign up

Quick Summary: Current access displays 2 out of 6 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Carcinogenic	31	4	Log in \| Sign up
Endocrine Disruptor	22	4	Log in \| Sign up

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View the Evidence: Problem Substances

Serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure.

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Pubmed Data : Environ Health Perspect. 2011 Mar ;119(3):319-25. PMID: 21362590

Article Published Date : Mar 01, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Hypertension : CK(2783) : AC(271)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9)

Environmental exposure to some POPs substantially increased risk of future type 2 diabetes in an elderly population.

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Pubmed Data : Diabetes Care. 2011 Jun 23. Epub 2011 Jun 23. PMID: 21700918

Article Published Date : Jun 23, 2011

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Pesticide-Induced Toxicity: Organochlorines : CK(32) : AC(4), Pesticide Toxicity : CK(147) : AC(45)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Persistent organic pollutants (POPs) : CK(93) : AC(12), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Exposure to organochloride compounds alter thyroid hormone levels during pregnancy.

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Pubmed Data : Environ Sci Technol. 2009 Oct 15;43(20):7909-15. PMID: 19921913

Article Published Date : Oct 15, 2009

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism : CK(537) : AC(78), Pregnancy: Environmental Exposures : CK(29) : AC(6)

Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) : CK(70) : AC(7), Hexachlorobenzene (HCB) : CK(20) : AC(2), Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Higher polychlorinated biphenyl (PCB) concentrations in breast tumors are strongly associated with tumors of poor prognosis.

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Pubmed Data : Cancer Causes Control. 2001 Jun;12(5):395-404. PMID: 11545454

Article Published Date : Jun 01, 2001

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

In a population of women in New York City breast cancer was strongly associated with DDE in serum.

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Pubmed Data : J Natl Cancer Inst. 1993 Apr 21;85(8):648-52. PMID: 8468722

Article Published Date : Apr 21, 1993

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Organochlorine compound exposures may disrupt thyroid function, resulting in neurotoxicity in preschool children.

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Pubmed Data : Environ Health Perspect. 2011 Jun 30. Epub 2011 Jun 30. PMID: 21719373

Article Published Date : Jun 30, 2011

Study Type : Human Study

Additional Links

Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Hypothyroidism : CK(537) : AC(78), Pesticide-Induced Toxicity: Organochlorines : CK(32) : AC(4), Pesticide Toxicity : CK(147) : AC(45), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Organochlorine compounds : CK(105) : AC(13)

Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid : CK(67) : AC(14)

Organochlorine pesticides are a potent risk factor for peripheral arterial diseases in obese persons.

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Pubmed Data : Atherosclerosis. 2011 May 10. Epub 2011 May 10. PMID: 21620405

Article Published Date : May 10, 2011

Study Type : Human Study

Additional Links

Diseases : Peripheral Arterial Disease : CK(260) : AC(26)

Problem Substances : Organochlorine compounds : CK(105) : AC(13)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Self-reported organochloride insecticide and fungicide use is associated with increased rates of thyroid disease.

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Pubmed Data : Am J Epidemiol. 2010 Feb 15;171(4):455-64. Epub 2010 Jan 8. PMID: 20061368

Article Published Date : Feb 15, 2010

Study Type : Human Study

Additional Links

Diseases : Hyperthyroidism : CK(189) : AC(33), Hypothyroidism : CK(537) : AC(78), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

There is a significant association between prostate cancer risk and exposure to the pesticides DDT, simazine, lindane and some of their active constituents.

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Pubmed Data : Prostate. 2010 Aug 26. Epub 2010 Aug 26. PMID: 20799287

Article Published Date : Aug 26, 2010

Study Type : Human Study

Additional Links

Diseases : Prostate Cancer : CK(998) : AC(288)

Additional Keywords : Increased Risk : CK(50) : AC(5)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens.

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Pubmed Data : Toxicol Lett. 2010 Oct 21. Epub 2010 Oct 21. PMID: 20920556

Article Published Date : Oct 21, 2010

Study Type : Animal Study

Additional Links

Diseases : Allergies : CK(502) : AC(92), Autoimmune Diseases : CK(5317) : AC(779), Pesticide Toxicity : CK(147) : AC(45)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Organophosphates : CK(38) : AC(7), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Allergenic : CK(25) : AC(5)

Organochlorine chemical exposure (e.g. dioxin) may be contributing to increasing prevalence of endometriosis.

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Pubmed Data : Environ Health Perspect. 2002 Jan;110(1):15-21. PMID: 11781160

Article Published Date : Jan 01, 2002

Study Type : Review

Additional Links

Diseases : Endometriosis : CK(156) : AC(32)

Problem Substances : Dioxins : CK(28) : AC(9), Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Organochlorine pesticide residues may generate an estrogenic pro-carcinogenic microenvironment in adipose mammary tissue.

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Pubmed Data : Breast Cancer Res. 2006;8(4):R47. PMID: 16859517

Article Published Date : Jan 01, 2006

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Estrogen Agonist : CK(13) : AC(4)

Various environmental toxins are associated with thyroid disruption.

Click here to read the entire abstract

Pubmed Data : Altern Med Rev. 2009 Dec;14(4):326-46. PMID: 20030460

Article Published Date : Dec 01, 2009

Study Type : Commentary

Additional Links

Diseases : Autoimmune Thyroiditis : CK(134) : AC(17), Hyperthyroidism : CK(189) : AC(33), Hypothyroidism : CK(537) : AC(78), Thyroid Cancer : CK(162) : AC(32), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Dioxins : CK(28) : AC(9), Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Phthalates : CK(151) : AC(24), Polybrominated diphenylethers (PBDEs) : CK(26) : AC(5), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

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