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Organochlorine pesticides

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Article Count - 30
Cumulative Knowledge - 268

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View the Evidence: Problem Substances

Chronic exposure to organochlorine compounds may contribute to type 2 diabetes and thyroid diseases.

Click here to read the entire abstract

Pubmed Data : Ann Ig. 2010 May-Jun;22(3):185-98. PMID: 20677670

Article Published Date : May 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Hyperthyroidism : CK(189) : AC(33), Hypothyroidism : CK(537) : AC(78), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2011 Mar ;119(3):319-25. PMID: 21362590

Article Published Date : Mar 01, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Hypertension : CK(2783) : AC(271)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9)

An association exists between increased PCB and p,p'-DDE serum concentrations and the risk of endometriosis.

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Pubmed Data : Environ Health Perspect. 2009 Jul;117(7):1070-5. Epub 2009 Mar 31. PMID: 19654915

Article Published Date : Jul 01, 2009

Study Type : Human Study

Additional Links

Diseases : Endometriosis : CK(156) : AC(32)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Background exposure to some organochlorine pesticides appears to lead to vitamin D deficiency in human.

Click here to read the entire abstract

Pubmed Data : PLoS One. 2012 ;7(1):e30093. Epub 2012 Jan 25. PMID: 22295072

Article Published Date : Jan 01, 2012

Study Type : Human Study

Additional Links

Substances : Vitamin D : CK(1682) : AC(238)

Diseases : Pesticide-Induced Toxicity: Organochlorines : CK(32) : AC(4), Vitamin D Deficiency : CK(495) : AC(45)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30)

Breast cancer patients have elevated levels of pesticides in their adipose tissue.

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 1994 Nov;15(11):2581-5. PMID: 7955109

Article Published Date : Nov 01, 1994

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Pesticide Toxicity : CK(147) : AC(45)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Concentrations of persistent organic chemicals do not consistently decline during lactation and can increase for some women.

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Pubmed Data : Environ Health Perspect. 2009 Oct;117(10):1625-31. Epub 2009 Jun 15. PMID: 20019916

Article Published Date : Oct 01, 2009

Study Type : Human Study

Additional Links

Diseases : Breastfeeding Concerns: Chemical Exposure : CK(91) : AC(15), Infant Chemical Exposures : CK(162) : AC(22)

Problem Substances : Dioxins : CK(28) : AC(9), Organochlorine pesticides : CK(260) : AC(30), Persistent organic pollutants (POPs) : CK(93) : AC(12), Polybrominated diphenylethers (PBDEs) : CK(26) : AC(5), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Bioaccumulator : CK(104) : AC(23)

DTT exposure is associated with increased breast cancer risk.

Click here to read the entire abstract

Pubmed Data : Asian Pac J Cancer Prev. 2010;11(1):173-80. PMID: 20593953

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621)

Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) : CK(70) : AC(7), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Exposure to low-dose persistent organic pollutants appears to contribute to development of obesity, dyslipidemia, and insulin resistance.

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Pubmed Data : PLoS One. 2011;6(1):e15977. Epub 2011 Jan 26. PMID: 21298090

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Dyslipidemias : CK(176) : AC(33), Insulin Resistance : CK(1034) : AC(221), Obesity : CK(1869) : AC(275)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Persistent organic pollutants (POPs) : CK(93) : AC(12), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Exposure to organochloride compounds alter thyroid hormone levels during pregnancy.

Click here to read the entire abstract

Pubmed Data : Environ Sci Technol. 2009 Oct 15;43(20):7909-15. PMID: 19921913

Article Published Date : Oct 15, 2009

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism : CK(537) : AC(78), Pregnancy: Environmental Exposures : CK(29) : AC(6)

Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) : CK(70) : AC(7), Hexachlorobenzene (HCB) : CK(20) : AC(2), Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Exposure to organochlorine pesticides during fetal life or via breast feeding may increase the risk of TGCT in young men.

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Pubmed Data : J Natl Cancer Inst. 2008 May 7;100(9):663-71. Epub 2008 Apr 29. PMID: 18445826

Article Published Date : May 07, 2008

Study Type : Human Study

Additional Links

Diseases : Breastfeeding Concerns: Chemical Exposure : CK(91) : AC(15), Prenatal Chemical Exposures : CK(322) : AC(86), Testicular Cancer : CK(37) : AC(7), Testicular Diseases : CK(38) : AC(15), Testicular Dysgenesis : CK(13) : AC(3), Testicular Neoplasms : CK(11) : AC(2)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Exposure to organochlorine pesticides is an independent risk factor of hepatocellular carcinoma.

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Pubmed Data : J Expo Sci Environ Epidemiol. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21915153

Article Published Date : Sep 14, 2011

Study Type : Human Study

Additional Links

Diseases : Pesticide-Induced Toxicity: Organochlorines : CK(32) : AC(4)

Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) : CK(70) : AC(7), Organochlorine pesticides : CK(260) : AC(30)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Higher polychlorinated biphenyl (PCB) concentrations in breast tumors are strongly associated with tumors of poor prognosis.

Click here to read the entire abstract

Pubmed Data : Cancer Causes Control. 2001 Jun;12(5):395-404. PMID: 11545454

Article Published Date : Jun 01, 2001

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

In a population of women in New York City breast cancer was strongly associated with DDE in serum.

Click here to read the entire abstract

Pubmed Data : J Natl Cancer Inst. 1993 Apr 21;85(8):648-52. PMID: 8468722

Article Published Date : Apr 21, 1993

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Maternal adipose tissue releases organochlorine pesticides into blood serum and they are carried over to umbilical cord blood.

Click here to read the entire abstract

Pubmed Data : Bull Environ Contam Toxicol. 2011 Mar ;86(3):289-93. Epub 2011 Feb 3. PMID: 21290101

Article Published Date : Mar 01, 2011

Study Type : Human Study

Additional Links

Diseases : Pesticide Toxicity : CK(147) : AC(45), Prenatal Chemical Exposures : CK(322) : AC(86), Prenatal Nutrition: Prevention of Problems : CK(357) : AC(41)

Additional Keywords : Chemical: Lindane : CK(22) : AC(7)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Bioaccumulator : CK(104) : AC(23)

Organochlorine pesticides may be associated with higher risk of peripheral neuropathic complications among those with glucose abnormalities, even beyond the influence of diabetes itself.

Click here to read the entire abstract

Pubmed Data : Diabetes. 2008 Nov;57(11):3108-11. Epub 2008 Jul 22. PMID: 18647952

Article Published Date : Nov 01, 2008

Study Type : Human Study

Additional Links

Diseases : Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetic Neuropathies : CK(203) : AC(32)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Persistent organic pollutants (POPs) : CK(93) : AC(12), Pesticides : CK(699) : AC(70)

Organochlorine pesticides may contribute to the initiation and pathogenesis of prostate cancer.

Click here to read the entire abstract

Pubmed Data : Chemosphere. 2010 Sep;81(4):464-8. PMID: 20817259

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Diseases : Prostate Cancer : CK(998) : AC(288)

Problem Substances : Dieldrin : CK(276) : AC(2), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Persistent organochlorine pesticides are commonly found in breast milk samples from women in mainland China.

Click here to read the entire abstract

Pubmed Data : Environ Pollut. 2011 Feb;159(2):524-31. Epub 2010 Nov 19. PMID: 21093969

Article Published Date : Feb 01, 2011

Study Type : Human Study

Additional Links

Diseases : Breastfeeding Concerns: Chemical Exposure : CK(91) : AC(15)

Additional Keywords : Meat-Pesticide Accumulation : CK(10) : AC(1)

Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) : CK(70) : AC(7), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Bioaccumulator : CK(104) : AC(23)

Pesticide exposure is associated with psychological distress and suicidal ideation.

Click here to read the entire abstract

Pubmed Data : Occup Environ Med. 2010 Nov;67(11):778-84. Epub 2010 Aug 25. PMID: 20798019

Article Published Date : Nov 01, 2010

Study Type : Human Study

Additional Links

Diseases : Pesticide-Induced Toxicity: Organophosphates : CK(17) : AC(6), Pesticide Toxicity : CK(147) : AC(45), Psychological Distress : CK(10) : AC(1), Suicidal Behavior : CK(83) : AC(10), Suicidal Ideation : CK(11) : AC(2)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Organophosphates : CK(38) : AC(7), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Self-reported organochloride insecticide and fungicide use is associated with increased rates of thyroid disease.

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2010 Feb 15;171(4):455-64. Epub 2010 Jan 8. PMID: 20061368

Article Published Date : Feb 15, 2010

Study Type : Human Study

Additional Links

Diseases : Hyperthyroidism : CK(189) : AC(33), Hypothyroidism : CK(537) : AC(78), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Serum concentrations of organochlorine pesticides are associated with prostate cancer incidence.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2010 Jan;118(1):60-6. PMID: 20056587

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Prostate Cancer : CK(998) : AC(288)

Problem Substances : Dieldrin : CK(276) : AC(2), Hexachlorocyclohexane : CK(23) : AC(4), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

The risk of type 2 diabetes is between 1.64-2.24 times higher in those with the greatest persistent organic pollutant exposures.

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21816981

Article Published Date : Aug 04, 2011

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Persistent organic pollutants (POPs) : CK(93) : AC(12)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

There is a relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults.

Click here to read the entire abstract

Pubmed Data : Diabetologia. 2007 Sep;50(9):1841-51. Epub 2007 Jul 12. PMID: 17624515

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Insulin Resistance : CK(1034) : AC(221), Metabolic Syndrome X : CK(645) : AC(122)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Persistent organic pollutants (POPs) : CK(93) : AC(12)

There is a significant association between prostate cancer risk and exposure to the pesticides DDT, simazine, lindane and some of their active constituents.

Click here to read the entire abstract

Pubmed Data : Prostate. 2010 Aug 26. Epub 2010 Aug 26. PMID: 20799287

Article Published Date : Aug 26, 2010

Study Type : Human Study

Additional Links

Diseases : Prostate Cancer : CK(998) : AC(288)

Additional Keywords : Increased Risk : CK(50) : AC(5)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

There is an association between serum concentrations of persistent organic pollutants and self-reported cardiovascular disease prevalence in women.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2007 Aug;115(8):1204-9. PMID: 17687448

Article Published Date : Aug 01, 2007

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases : CK(5138) : AC(641)

Problem Substances : Dioxins : CK(28) : AC(9), Organochlorine pesticides : CK(260) : AC(30), Persistent organic pollutants (POPs) : CK(93) : AC(12), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens.

Click here to read the entire abstract

Pubmed Data : Toxicol Lett. 2010 Oct 21. Epub 2010 Oct 21. PMID: 20920556

Article Published Date : Oct 21, 2010

Study Type : Animal Study

Additional Links

Diseases : Allergies : CK(502) : AC(92), Autoimmune Diseases : CK(5317) : AC(779), Pesticide Toxicity : CK(147) : AC(45)

Problem Substances : Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Organophosphates : CK(38) : AC(7), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Allergenic : CK(25) : AC(5)

Health Guide: Chemical Exposures

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