Oseltamivir (trade name Tamiflu)

Oseltamivir (trade name Tamiflu)

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View the Evidence: Problem Substances

Oseltamivir for treatment of influenza in infants less than one year results in complications in 54% of the patients with the most serious of which were meningitis in 1 infant (1%), pneumonia in 9 (6%), and otitis media in 2 (1%)

Pubmed Data : Pediatr Infect Dis J. 2010 Jun;29(6):495-8. PMID: 20035245
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Infant Infections : CK(420) : AC(45), Influenza : CK(654) : AC(102), Meningitis: Drug-Induced : CK(20) : AC(1), Pneumonia: Drug-Induced : CK(24) : AC(3)
Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Oseltamivir has been reported to cause neuropsychiatric disorders in children and may be particularly dangerous to infants.

Pubmed Data : Prescrire Int. 2006 Oct;15(85):182-3. PMID: 17128526
Article Published Date : Oct 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Lyell syndrome : CK(20) : AC(1), Psychiatric Disorders : CK(71) : AC(10)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus has been reported.

Pubmed Data : Emerg Infect Dis. 2010 Jul;16(7):1068-75. PMID: 20587176
Article Published Date : Jul 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Swine Flu Associated Virus : CK(156) : AC(33)
Additional Keywords : Drug Resistant Pathogens : CK(46) : AC(7)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

The data is inconclusive as to whether or not neuraminidase inhibitors are effective at preventing and treating influenza in healthy adults.

Pubmed Data : Health Technol Assess. 2010 Oct;14(46):355-458. PMID: 20945587
Article Published Date : Oct 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Influenza : CK(654) : AC(102), Influenza A : CK(305) : AC(73), Influenza B : CK(72) : AC(14)
Problem Substances : Neuraminidase inhibitors : CK(20) : AC(1), Oseltamivir (trade name Tamiflu) : CK(142) : AC(14), Zanamivir : CK(20) : AC(1)

Adverse drug effects following oseltamivir mass treatment and prophylaxis in a school outbreak of 2009 pandemic influenza A(H1N1) in June 2009, Sheffield, United Kingdom has been reported.

Pubmed Data : Euro Surveill. 2010 May 13;15(19):pii/19565. Epub 2010 May 13. PMID: 20483106
Article Published Date : May 13, 2010
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Swine Flu Associated Virus : CK(156) : AC(33)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Oseltamivir is not sufficiently effective or safe for the prevention of influenza in children.

Pubmed Data : Prescrire Int. 2007 Feb;16(87):9-11. PMID: 17323516
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Diseases : Childhood Infections : CK(275) : AC(29), Influenza : CK(654) : AC(102), Vaccine-induced Toxicity : CK(1130) : AC(163)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Oseltamivir resistance during treatment of influenza A (H5N1) infection has been reported.

Pubmed Data : N Engl J Med. 2005 Dec 22;353(25):2667-72. PMID: 16371632
Article Published Date : Dec 22, 2005
Study Type : Human Study
Additional Links
Diseases : Avian Influenza : CK(23) : AC(11), Influenza A : CK(305) : AC(73)
Additional Keywords : Drug Resistant Pathogens : CK(46) : AC(7)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Prophylactic oseltamivir treatment in children resulted in 51% experiencing adverse reactions.

Pubmed Data : Euro Surveill. 2009 Jul 30;14(30):19285. Epub 2009 Jul 30. PMID: 19643061
Article Published Date : Jul 30, 2009
Study Type : Human Study
Additional Links
Diseases : Childhood Infections : CK(275) : AC(29), Drug-Induced Toxicity : CK(560) : AC(78), Influenza : CK(654) : AC(102)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

The prophylactic use of oseltamivir in children results in side effects including high rates of gastrointestinal and neuropsychiatric reactions.

Pubmed Data : Euro Surveill. 2009 Jul 30;14(30):19287. Epub 2009 Jul 30. PMID: 19643062
Article Published Date : Jul 30, 2009
Study Type : Human Study
Additional Links
Diseases : Childhood Infections : CK(275) : AC(29), Drug-Induced Toxicity : CK(560) : AC(78)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Oseltamivir-resistance to pandemic (H1N1) 2009 influenza has been reported in a severely ill patient.

Pubmed Data : Med J Aust. 2010 Feb 1;192(3):166-8. PMID: 20121687
Article Published Date : Feb 01, 2010
Study Type : Human: Case Report
Additional Links
Additional Keywords : Drug Resistant Pathogens : CK(46) : AC(7)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Severe, delayed-onset neuropsychiatric symptoms after administration of high-dose oseltamivir has been reported in a critically ill patient.

Pubmed Data : Clin Infect Dis. 2010 Apr 1;50(7):e47-9. PMID: 20192728
Article Published Date : Apr 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Psychiatric Disorders : CK(71) : AC(10)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Toxic epidermal necrolysis after treatment with oseltamivir has been reported.

Pubmed Data : Arch Argent Pediatr. 2010 Jun;108(3):e76-8. PMID: 20544126
Article Published Date : Jun 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Toxic Epidermal Necrolysis : CK(7) : AC(3)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

"Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats."

Pubmed Data : J Toxicol Sci. 2012 ;37(6):1217-23. PMID: 23208436
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Animal research on Tamiflu shows that the infant brain absorbs it more readily than those who are older. This may explain why neuropsychiatric side effects of oseltamivir occur in young patients.

Pubmed Data : Neurosci Lett. 2011 May 20 ;495(3):187-91. Epub 2011 Apr 2. PMID: 21443926
Article Published Date : May 19, 2011
Study Type : Animal Study
Additional Links
Diseases : Infant Chemical Exposures : CK(162) : AC(22)
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Biodistribution and metabolism of the anti-influenza drug [11C]oseltamivir and its active metabolite [11C]Ro 64-0802 in mice.

Pubmed Data : Nucl Med Biol. 2009 Jan ;36(1):47-55. PMID: 19181268
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Lipopolysaccharide-induced inflammation in mice increases the penetration of oseltamivir and its active metabolite into the brain.

Pubmed Data : J Pharm Pharmacol. 2009 Oct;61(10):1397-400. PMID: 19814874
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Cases of early deterioration leading to death have been reported to occur as a result of oseltamivir use.

Pubmed Data : Int J Risk Saf Med. 2011 ;23(4):201-15. PMID: 22156085
Article Published Date : Dec 31, 2010
Study Type : Review
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(78)
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Neuropsychiatric disorders have been reported in connection with oseltamivir use.

Pubmed Data : Prescrire Int. 2007 Oct;16(91):200. PMID: 17926837
Article Published Date : Oct 01, 2007
Study Type : Commentary
Additional Links
Diseases : Delirium: Drug-Induced : CK(26) : AC(6), Drug-Induced Toxicity : CK(560) : AC(78), Hallucinations : CK(1) : AC(1), Parasuicide : CK(11) : AC(2), Psychiatric Disorders : CK(71) : AC(10), Suicidal Behavior : CK(83) : AC(10)
Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Related Blogs

FDA Approves Neurotoxic Flu Drug For Infants Less Than One
Written by Sayer Ji, Founder
The recent decision by the FDA to approve the use of the antiviral drug Tamiflu for infants as young as 2 weeks old, belies an underlying trajectory within our regulatory agencies towards sheer insanity.
Research Confirms Herbal Medicines Inhibit Influenza
Written by Case Adams, Naturopath
New research from Japan and China have confirmed that certain medicinal herbs and their constituents have the ability to directly inhibit influenza as well as stimulate the body's own immune system in order to counteract the flu virus.

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