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Parabens

Parabens

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Article Count - 21
Cumulative Knowledge - 68

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Quick Summary: Current access displays 2 out of 13 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
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Infertility: Male	6	4	Log in \| Sign up

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View the Evidence: Problem Substances

100% of male subjects tested had measurable urinary concentrations of parabens, and concentrations correlate with DNA damage in sperm.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2011 Feb ;119(2):252-7. Epub 2010 Sep 28. PMID: 20876036

Article Published Date : Feb 01, 2011

Study Type : Human Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Infertility: Male : CK(209) : AC(52)

Problem Substances : Parabens : CK(59) : AC(21)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Parabens are found in significant concentration in human breast tumors.

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2004 Jan-Feb;24(1):5-13. PMID: 14745841

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Parabens : CK(59) : AC(21)

Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006.

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Pubmed Data : Environ Health Perspect. 2010 May ;118(5):679-85. Epub 2010 Jan 4. PMID: 20056562

Article Published Date : May 01, 2010

Study Type : Human Study

Additional Links

Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Parabens-Associated Toxicity : CK(6) : AC(4)

Problem Substances : Parabens : CK(59) : AC(21)

"Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum."

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Pubmed Data : J Appl Toxicol. 2012 Mar ;32(3):219-32. Epub 2012 Jan 12. PMID: 22237600

Article Published Date : Mar 01, 2012

Study Type : Human In Vitro

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Parabens : CK(59) : AC(21)

Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF-7 human breast cancer cells.

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2013 May ;33(5):390-8. Epub 2013 Jan 31. PMID: 23364952

Article Published Date : Apr 30, 2013

Study Type : Human In Vitro

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Parabens : CK(59) : AC(21)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Estrogenic : CK(59) : AC(12)

Exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system.

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Pubmed Data : Toxicol Ind Health. 2001 Feb;17(1):31-9. PMID: 12004923

Article Published Date : Feb 01, 2001

Study Type : Animal Study

Additional Links

Diseases : Androgen Deficiency : CK(42) : AC(14), Infertility: Male : CK(209) : AC(52), Testosterone: Too Low : CK(369) : AC(70)

Problem Substances : Parabens : CK(59) : AC(21)

Isobutyl-parabenexposure during gestation has adverse effects on anxiety and learning abilities in offspring, especially males, and into adulthood.

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Pubmed Data : Neurosci Res. 2009 Oct;65(2):136-40. Epub 2009 Jun 26. PMID: 19560493

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Parabens : CK(59) : AC(21)

Maternal exposure to butyl paraben decreases sperm number and motility in offspring.

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Pubmed Data : J Vet Med Sci. 2002 Mar;64(3):227-35. PMID: 11999442

Article Published Date : Mar 01, 2002

Study Type : Animal Study

Additional Links

Diseases : Infertility: Female : CK(182) : AC(33), Prenatal Chemical Exposures : CK(322) : AC(86), Sperm Quality: Low : CK(162) : AC(28)

Problem Substances : Parabens : CK(59) : AC(21)

Occurrence of and dietary exposure to parabens in foodstuffs from the United States.

Click here to read the entire abstract

Pubmed Data : Environ Sci Technol. 2013 Apr 16 ;47(8):3918-25. Epub 2013 Apr 2. PMID: 23506043

Article Published Date : Apr 15, 2013

Study Type : Environmental

Additional Links

Diseases : Chemical Poisoning: Accumulated Environmental Toxins : CK(17) : AC(4)

Problem Substances : Parabens : CK(59) : AC(21)

Paraben exhibits uterotrphic activity in both immature and adult oavariectomized mice.

Click here to read the entire abstract

Pubmed Data : Environ Res. 1997 Nov;75(2):130-4. PMID: 9417843

Article Published Date : Nov 01, 1997

Study Type : Animal Study

Additional Links

Diseases : Uterine Cancer : CK(24) : AC(10)

Problem Substances : Parabens : CK(59) : AC(21)

Parabens increases the proliferation of breast cancer cell lines and increases uterine weight.

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2003 Jan-Feb;23(1):43-51. PMID: 12518336

Article Published Date : Jan 01, 2003

Study Type : Animal Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621), Uterine Cancer : CK(24) : AC(10)

Problem Substances : Parabens : CK(59) : AC(21)

Parabens may interfere with steroidogenesis.

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2008 Nov;106(1):206-13. Epub 2008 Jul 22. PMID: 18648085

Article Published Date : Nov 01, 2008

Study Type : Animal Study

Additional Links

Diseases : Hormone Insufficency : CK(29) : AC(7)

Problem Substances : Parabens : CK(59) : AC(21)

Prolonged exposure to a low-dose of bisphenol A increases spontaneous motor activity in adult male rats.

Click here to read the entire abstract

Pubmed Data : J Physiol Sci. 2013 May 8. Epub 2013 May 8. PMID: 23653311

Article Published Date : May 07, 2013

Study Type : Animal Study

Additional Links

Diseases : Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30), Attention Deficit Hyperactivity Disorder : CK(160) : AC(14)

Problem Substances : Parabens : CK(59) : AC(21)

Propyl paraben has an adverse effect on the male reproductive system.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2002 Dec;40(12):1807-13. PMID: 12419695

Article Published Date : Dec 01, 2002

Study Type : Animal Study

Additional Links

Diseases : Androgen Deficiency : CK(42) : AC(14), Infertility: Male : CK(209) : AC(52), Testosterone: Too Low : CK(369) : AC(70)

Problem Substances : Parabens : CK(59) : AC(21)

"Parabens detection in different zones of the human breast: consideration of source and implications of findings."

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2012 May ;32(5):305-9. Epub 2012 Mar 7. PMID: 22408000

Article Published Date : May 01, 2012

Study Type : Review

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Estrogen : CK(5) : AC(2)

Problem Substances : Parabens : CK(59) : AC(21)

Bisphenol A, 17beta-estradiol, and Parabens increase rat uterine weights.

Click here to read the entire abstract

Pubmed Data : Environ Res. 2005 May;98(1):40-5. PMID: 15721882

Article Published Date : May 01, 2005

Study Type : In Vitro Study

Additional Links

Diseases : Fibroids: Uterine : CK(46) : AC(16), Uterine Cancer : CK(24) : AC(10)

Additional Keywords : Sunscreen : CK(1) : AC(1)

Problem Substances : 17beta-estradiol : CK(38) : AC(7), Bisphenol A : CK(217) : AC(54), Parabens : CK(59) : AC(21)

Endocrine disruptors, such as parabens, should be investigated as a possible contributor to increased incidence of breast cancer in women.

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2004 May-Jun;24(3):167-76. PMID: 15211609

Article Published Date : May 01, 2004

Study Type : Review

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Parabens : CK(59) : AC(21)

Methylparaben potentiates UV-induced damage of skin keratinocytes.

Click here to read the entire abstract

Pubmed Data : Toxicology. 2006 Oct 3;227(1-2):62-72. Epub 2006 Jul 28. PMID: 16938376

Article Published Date : Oct 03, 2006

Study Type : In Vitro Study

Additional Links

Diseases : Skin Diseases: Photo-Aging : CK(365) : AC(47)

Problem Substances : Parabens : CK(59) : AC(21)

Paraben exposures may contribute to breast cancer, male reproductive problems and malignant melanoma.

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2008 Jul;28(5):561-78. PMID: 18484575

Article Published Date : Jul 01, 2008

Study Type : Review

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621), Infertility: Male : CK(209) : AC(52), Malignant Melanoma : CK(189) : AC(8)

Problem Substances : Parabens : CK(59) : AC(21)

Parabens exposure, especially subcutaneous and topical routes of exposure, are associated with increased risk for breast cancer. .

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2003 Sep-Oct;23(5):285-8. PMID: 12975767

Article Published Date : Sep 01, 2003

Study Type : Commentary

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Parabens : CK(59) : AC(21)

Parabens have cytotoxic effects on rat liver cells.

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 1999 Sep 1;58(5):811-6. PMID: 10449191

Article Published Date : Sep 01, 1999

Study Type : In Vitro Study

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175)

Problem Substances : Parabens : CK(59) : AC(21)

Parabens increases proliferation in human breast cancer cell lines.

Click here to read the entire abstract

Pubmed Data : J Appl Toxicol. 2005 Jul-Aug;25(4):301-9. PMID: 16021681

Article Published Date : Jul 01, 2005

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Parabens : CK(59) : AC(21)

Parabens may adversely effect mitochondrial function in the testes of men, interfering with their fertility.

Click here to read the entire abstract

Pubmed Data : Reprod Toxicol. 2009 Jan;27(1):1-7. Epub 2008 Oct 21. PMID: 19007877

Article Published Date : Jan 01, 2009

Study Type : Commentary

Additional Links

Diseases : Infertility: Male : CK(209) : AC(52)

Problem Substances : Parabens : CK(59) : AC(21)

Various compounds used in sunscreens and musks have estrogenic activity.

Click here to read the entire abstract

Pubmed Data : J Toxicol Environ Health A. 2005 Feb 27;68(4):239-51. PMID: 15799449

Article Published Date : Feb 27, 2005

Study Type : In Vitro Study

Additional Links

Problem Substances : Homosalate : CK(11) : AC(2), Octyl P-Dimethylaminobenzoate (PABA) : CK(2) : AC(2), Parabens : CK(59) : AC(21), Sunscreen : CK(71) : AC(14)

Adverse Pharmacological Actions : Estrogenic : CK(59) : AC(12)

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