Polystyrene nanoparticles

Polystyrene nanoparticles

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Article Count - 2
Cumulative Knowledge - 16

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View the Evidence: Problem Substances

Oral exposure to polystyrene nanoparticles affects iron absorption and caused remodelling of the intestinal villi in chickens.

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Pubmed Data : Nat Nanotechnol. 2012 ;7(4):264-71. Epub 2012 Feb 12. PMID: 22327877

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Diseases : Anemia: Iron Deficiency : CK(85) : AC(11), Iron Deficiency/Malabsorption : CK(2) : AC(1), Malabsorption Syndrome : CK(34) : AC(11), Microvilli atrophy : CK(4) : AC(1)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Polystyrene nanoparticle uptake by the rat gastrointestinal mucosa results in their systemic bodily distribution.

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Pubmed Data : J Pharm Pharmacol. 1990 Dec ;42(12):821-6. PMID: 1983142

Article Published Date : Dec 01, 1990

Study Type : Animal Study

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Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Polystyrene nanoparticles are capable of entering through the blood-brain-barrier in an animal model of brain ischemia and perfusion.

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Pubmed Data : Anal Chem. 2004 Aug 1 ;76(15):4465-71. PMID: 15283589

Article Published Date : Aug 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Blood-Brain-Barrier Disorders : CK(25) : AC(15)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Polystyrene nanoparticles are preferentially absorbed through lymphoid versus non-lymphoid tissue in animals.

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Pubmed Data : J Drug Target. 1994 ;2(2):151-6. PMID: 8069593

Article Published Date : Jan 01, 1994

Study Type : Animal Study

Additional Links

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages.

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Pubmed Data : ACS Nano. 2011 Dec 27 ;5(12):9648-57. Epub 2011 Dec 8. PMID: 22111911

Article Published Date : Dec 27, 2011

Study Type : In Vitro Study

Additional Links

Diseases : Inflammation : CK(1077) : AC(363)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17), Inflammatory : CK(150) : AC(37)

Nanoparticles exhibit size dependent neurotoxicity.

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Pubmed Data : Arch Toxicol. 2011 Dec ;85(12):1575-88. Epub 2011 Sep 1. PMID: 21881955

Article Published Date : Dec 01, 2011

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Polymeric (polystyrene) nano particles have hemolytic properties.

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Pubmed Data : IEEE Trans Nanobioscience. 2011 Dec ;10(4):259-61. Epub 2011 Nov 22. PMID: 22128012

Article Published Date : Dec 01, 2011

Study Type : In Vitro Study

Additional Links

Diseases : Anemia: Hemolytic : CK(76) : AC(8), Blood Diseases : CK(30) : AC(2)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Adverse Pharmacological Actions : Hemolytic : CK(17) : AC(4)

Polystyrene nanoparticles absorption within cells can be inhibited with genistein

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Pubmed Data : PLoS One. 2011 ;6(9):e24438. Epub 2011 Sep 19. PMID: 21949717

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Genistein : CK(450) : AC(174)

Diseases : Nanoparticle Toxicity: Polystyrene : CK(1) : AC(1)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Polystyrene nanoparticles affects blood coagulation.

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Pubmed Data : Nanomedicine. 2011 Dec 23. Epub 2011 Dec 23. PMID: 22197724

Article Published Date : Dec 23, 2011

Study Type : In Vitro Study

Additional Links

Diseases : Blood Coagulation Disorders : CK(42) : AC(8)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Review: factors affecting the oral uptake and translocation of polystyrene nanoparticles

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Pubmed Data : J Drug Target. 1995 ;3(1):65-70. PMID: 7655823

Article Published Date : Jan 01, 1995

Study Type : Review

Additional Links

Additional Keywords : Lectins : CK(58) : AC(36)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Structural changes in apolipoproteins bound to nano particles have been observed.

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Pubmed Data : Langmuir. 2011 Dec 6 ;27(23):14360-9. Epub 2011 Nov 2. PMID: 21978381

Article Published Date : Dec 06, 2011

Study Type : In Vitro Study

Additional Links

Diseases : Apolipoprotein Disorders : CK(48) : AC(9)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Uptake of particulate vaccine adjuvants (e.g. nanoparticle polystyrene) by dendritic cells activates the NALP3 inflammasome.

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Pubmed Data : Proc Natl Acad Sci U S A. 2009 Jan 20 ;106(3):870-5. Epub 2009 Jan 12. PMID: 19139407

Article Published Date : Jan 20, 2009

Study Type : In Vitro Study

Additional Links

Pharmacological Actions : Interleukin-1 beta downregulation : CK(177) : AC(70)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2), Vaccine Adjuvants : CK(383) : AC(77)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17), Immunotoxic : CK(230) : AC(38)

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