Proton-Pump Inhibitors

Proton-Pump Inhibitors

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View the Evidence: Problem Substances

A number of commonly used drugs interfere with the absorption of lovothyroxine.

Pubmed Data : Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92. PMID: 19942153
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(537) : AC(78)
Problem Substances : Antacids: Aluminium-Containing : CK(22) : AC(3), Bile Acid Sequestrants : CK(10) : AC(1), Calcium Carbonate : CK(176) : AC(19), Ferrous Sulphate : CK(22) : AC(3), Phosphate Binders : CK(10) : AC(1), Proton-Pump Inhibitors : CK(218) : AC(27), Raloxifene : CK(103) : AC(11), Sucralfate : CK(10) : AC(1)

Children exposed to proton pump inhibitor therapy are at higher risk for the development of Clostridium difficile-associated disease.

Pubmed Data : Aliment Pharmacol Ther. 2009 Dec 29. Epub 2009 Dec 29. PMID: 20047577
Article Published Date : Dec 29, 2009
Study Type : Human Study
Additional Links
Diseases : Acid Reflux: In Infants & Children : CK(20) : AC(2), Childhood Infections : CK(275) : AC(29), Clostridium Infections : CK(171) : AC(29), Infant Infections : CK(420) : AC(45)
Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Chronic PPI use resulted in significant increases in CGA (including the tumor marker chromogranin A) and significant increases in gastrin compared to controls.

Pubmed Data : Pancreas. 2012 Mar 28. Epub 2012 Mar 28. PMID: 22460728
Article Published Date : Mar 28, 2012
Study Type : Human Study
Additional Links
Diseases : Neuroendocrine Tumors : CK(10) : AC(1)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Circulating Gastrin and Chromogranin A: Elevated : CK(10) : AC(1), Tumor Marker Elevation: Chromogranin : CK(10) : AC(1)

Concomitant use of a proton pump inhibitor and clopidogrel compared with clopidogrel alone was associated with a higher rate of major adverse cardiovascular events within 1 year after coronary stent placement.

Pubmed Data : Pharmacotherapy. 2010 Aug;30(8):787-96. PMID: 20653354
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Coronary Stenting : CK(33) : AC(5)
Additional Keywords : Drug Interaction : CK(64) : AC(8)
Problem Substances : Clopidogrel : CK(171) : AC(16), Proton-Pump Inhibitors : CK(218) : AC(27)

Current use of gastric acid-suppressive therapy was associated with an increased risk of community-acquired pneumonia.

Pubmed Data : JAMA. 2004 Oct 27;292(16):1955-60. PMID: 15507580
Article Published Date : Oct 27, 2004
Study Type : Human Study
Additional Links
Diseases : Pneumonia : CK(330) : AC(40)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Long-term proton pump inhibitor therapy is associated with an increased risk of hip fracture.

Pubmed Data : JAMA. 2006 Dec 27;296(24):2947-53. PMID: 17190895
Article Published Date : Dec 27, 2006
Study Type : Human Study
Additional Links
Diseases : Bone Fractures : CK(1610) : AC(69), Hip Fracture : CK(1724) : AC(21), Osteoporosis : CK(1171) : AC(205)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Medically treated patients with mild or absent GERD symptoms have significantly higher odds of adenocarcinogenesis compared with medically treated patients with severe GERD symptoms.

Pubmed Data : Arch Surg. 2011 Jul;146(7):851-8. PMID: 21768433
Article Published Date : Jul 01, 2011
Study Type : Human Study
Additional Links
Diseases : Esophageal Cancer : CK(328) : AC(55), Gastroesophageal Reflux : CK(278) : AC(41)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Omeprazole has been linked to interstitial nephritis.

Pubmed Data : Br J Clin Pharmacol. 2010 May;69(5):516-9. PMID: 20573087
Article Published Date : May 01, 2010
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Nephritis : CK(29) : AC(6)
Problem Substances : Omeprazole (trade name Prisolec) : CK(46) : AC(7)

Over-use of proton pump inhibitors may be fuelling the current epidemic of Clostridium difficile-associated diarrhoea.

Pubmed Data : J Hosp Infect. 2008 Sep;70(1):1-6. Epub 2008 Jul 3. PMID: 18602190
Article Published Date : Sep 01, 2008
Study Type : Human Study
Additional Links
Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72), Drug-Induced Toxicity : CK(560) : AC(78)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Patients in hospital who received proton pump inhibitors were at increased risk of Clostridium difficile diarrhea.

Pubmed Data : CMAJ. 2004 Jul 6;171(1):33-8. PMID: 15238493
Article Published Date : Jul 06, 2004
Study Type : Human Study
Additional Links
Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Proton pump inhibitor therapy may increased the risk of clostridium difficile-associated diarrhea.

Pubmed Data : J Natl Med Assoc. 2007 May;99(5):500-4. PMID: 17534007
Article Published Date : May 01, 2007
Study Type : Human Study
Additional Links
Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72)
Additional Keywords : Increased Risk : CK(50) : AC(5)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Proton pump inhibitors are not superior to placebo and increase the risk of respiratory tract infections in infants with symptoms of GERD.

Pubmed Data : J Pediatr. 2009 Apr;154(4):514-520.e4. Epub 2008 Dec 3. PMID: 19054529
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Gastroesophageal Reflux : CK(278) : AC(41), Gastroesophageal Reflux: Infant and Children : CK(30) : AC(3)
Additional Keywords : Drugs that are Worse than Placebo : CK(10) : AC(1)
Problem Substances : Lansoprazole : CK(20) : AC(2)

Proton pump inhibitors reduce the bioavailability of dietary vitamin C.

Pubmed Data : Aliment Pharmacol Ther. 2005 Sep 15;22(6):539-45. PMID: 16167970
Article Published Date : Sep 15, 2005
Study Type : Human Study
Additional Links
Diseases : Vitamin C Deficiency : CK(12) : AC(3)
Additional Keywords : Drug: Omeprazole : CK(90) : AC(15)
Problem Substances : Omeprazole (trade name Prisolec) : CK(46) : AC(7), Proton-Pump Inhibitors : CK(218) : AC(27)

Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy, indicating the drug causes rebound acid hypersecretion (RAHS).

Pubmed Data : Gastroenterology. 2009 Jul;137(1):80-7, 87.e1. Epub 2009 Apr 10. PMID: 19362552
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acid Reflux : CK(288) : AC(42), Dyspepsia : CK(422) : AC(21)
Additional Keywords : Drug: Omeprazole : CK(90) : AC(15)
Problem Substances : Omeprazole (trade name Prisolec) : CK(46) : AC(7)

Severe hypomagnesaemia and subsequent seizure has been reported in long-term users of proton-pump inhibitors.

Pubmed Data : Clin Endocrinol (Oxf). 2008 Aug;69(2):338-41. Epub 2008 Jan 23. PMID: 18221401
Article Published Date : Aug 01, 2008
Study Type : Human Study
Additional Links
Diseases : Magnesium Deficiency : CK(81) : AC(12), Seizures : CK(122) : AC(28)
Additional Keywords : Drug: Omeprazole : CK(90) : AC(15)
Problem Substances : Omeprazole (trade name Prisolec) : CK(46) : AC(7)

The use of the proton pump inhibitor pantoprazole increases the risk of post-operative nosocomial pneumonia in cardiothoracic surgery patients versus the H2 blocker ranitidine.

Pubmed Data : Chest. 2009 Aug;136(2):440-7. Epub 2009 Mar 24. PMID: 19318661
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Diseases : Pneumonia : CK(330) : AC(40)
Problem Substances : Pantoprazole : CK(10) : AC(1), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.

Pubmed Data : Pediatrics. 2006 May;117(5):e817-20. PMID: 16651285
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Diseases : Childhood Infections : CK(275) : AC(29), Gastroenteritis : CK(96) : AC(11), Infection: In Infants & Children : CK(111) : AC(11), Pneumonia : CK(330) : AC(40)
Additional Keywords : Drug: Omeprazole : CK(90) : AC(15)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Use of proton-pump inhibitors is associated with increased risk of diarrhea in the elderly.

Pubmed Data : Scand J Prim Health Care. 2010 Sep;28(3):154-9. PMID: 20586539
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Diseases : Diarrhea : CK(544) : AC(72)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

"A patient on long-term proton pump inhibitors develops sudden seizures and encephalopathy"

Pubmed Data : Case Rep Gastrointest Med. 2012 ;2012:632721. Epub 2012 Nov 18. PMID: 23213582
Article Published Date : Dec 31, 2011
Study Type : Human: Case Report
Additional Links
Diseases : Encephalopathies : CK(11) : AC(5), Magnesium Deficiency : CK(81) : AC(12), Seizures: Drug-Induced : CK(26) : AC(6)
Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Acid blockers increase the risk of prion infection in mice.

Pubmed Data : Scand J Gastroenterol. 2011 Sep 22. Epub 2011 Sep 22. PMID: 21936725
Article Published Date : Sep 22, 2011
Study Type : Animal Study
Additional Links
Diseases : Animal Diseases: Scrapie : CK(4) : AC(2), Prion Diseases : CK(6) : AC(4), Scrapie : CK(2) : AC(1)
Problem Substances : Acid Blockers : CK(244) : AC(31), Omeprazole (trade name Prisolec) : CK(46) : AC(7)

Histamine receptor antagonists and proton pump inhibitors cause gastric hyperplasia and cancer in rats.

Pubmed Data : Toxicol Pathol. 1988;16(2):288-98. PMID: 2903544
Article Published Date : Jan 01, 1988
Study Type : Animal Study
Additional Links
Diseases : Gastric Cancer : CK(373) : AC(111)
Additional Keywords : Drug: Omeprazole : CK(90) : AC(15)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Omeprazole (trade name Prisolec) : CK(46) : AC(7), Proton-Pump Inhibitors : CK(218) : AC(27)

Long-acting inhibitors of gastric acid secretion may result in endocrine cell hyperplasia and cancer in the gastric mucosa.

Pubmed Data : Eur J Clin Invest. 1990 Oct;20 Suppl 1:S65-71. PMID: 2125000
Article Published Date : Oct 01, 1990
Study Type : Animal Study
Additional Links
Diseases : Gastric Cancer : CK(373) : AC(111)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

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