Saccharin

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View the Evidence: Problem Substances

Artificial sweetener consumption is associated with urinary tract tumors.

Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Urinary Tract Cancer : CK(22) : AC(4)
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

Intense sweetness can surpass cocaine reward in the animal model.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2007 ;2(8):e698. Epub 2007 Aug 1. PMID: 17668074
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Problem Substances : Saccharin : CK(18) : AC(7)

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult rats, at similar total caloric intake levels.

Pubmed Data : Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID: 23088901
Article Published Date : Oct 18, 2012
Study Type : Animal Study
Additional Links
Diseases : Appetite Disorders : CK(105) : AC(13), Obesity : CK(1849) : AC(275), Overweight : CK(2176) : AC(342)
Problem Substances : Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

two-week supplementation of a low carbohydrate diet with sucralose, saccharin or acesulfame-K up-regulated intestinal SGLT1 expression levels to

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Sep 18 ;104(38):15075-80. Epub 2007 Aug 27. PMID: 17724332
Article Published Date : Sep 17, 2007
Study Type : Animal Study
Additional Links
Additional Keywords : cephalic phase effect
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Saccharin : CK(18) : AC(7), Sucralose : CK(15) : AC(10)

Aspartame, Acesulfame potassium and Saccharin have potential genotoxicity.

Pubmed Data : Drug Chem Toxicol. 2008;31(4):447-57. PMID: 18850355
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

Long term consumption of artificial sweeteners might accelerate atherosclerosis and aging.

Pubmed Data : Mol Cells. 2011 May ;31(5):461-70. Epub 2011 Apr 21. PMID: 21533907
Article Published Date : May 01, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Aging : CK(1351) : AC(369), Atherosclerosis : CK(523) : AC(77)
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Aspartame : CK(103) : AC(30), Saccharin : CK(18) : AC(7)

The artificial sweeteners sodium cyclamate, aspartame, acesulfame potassium, and saccharin have insulin-releasing action on pancreatic beta cells.

Pubmed Data : Cell Signal. 1998 Nov;10(10):727-33. PMID: 9884024
Article Published Date : Nov 01, 1998
Study Type : In Vitro Study
Additional Links
Diseases : Hyperinsulinism : CK(1182) : AC(41)
Problem Substances : Acesulfame potassium : CK(22) : AC(8), Artificial Sweeteners : CK(209) : AC(51), Saccharin : CK(18) : AC(7), Sodium Cyclamate : CK(15) : AC(4)

Various food additives, preservatives, fungicides and artificial sweeteners have been demonstrated to have the potential to damage DNA in gastrointestinal organs.

Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896
Article Published Date : Aug 26, 2002
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Biphenyl : CK(1) : AC(1), Butylated hydroxyanisole (BHA) : CK(9) : AC(7), Butylated Hydroxytoluene (BHT) : CK(74) : AC(44), Saccharin : CK(18) : AC(7), Sodium Cyclamate : CK(15) : AC(4), Sodium o-phenylphenol : CK(1) : AC(1), Sucralose : CK(15) : AC(10), Thiabendazole : CK(1) : AC(1)

Related Blogs

Artificial Sweeteners Found More Weight-Promoting Than Sugar
Written by Sayer Ji, Founder
A new study published this month in the journal Appetite revealed that when rats were given the synthetic sweeteners saccharin and aspartame, compared to sucrose (table sugar), they gained more weight even at similar total caloric intake levels
Study: Saccharin And Sugar Found More Addictive Than Cocaine
Written by Sayer Ji, Founder
Sugar and artificial sweeteners are so accessible, affordable and socially sanctioned, that few consider their habitual consumption to be a problem on the scale of say, addiction to cocaine. But if recent research is correct, their addictive potential could be even worse.
Sweet! Dieting without Deprivation
Written by Sayer Ji, Founder
So, you are looking to lose a few pounds, or keep them off. What better way to accomplish this feat than to eliminate both empty sugar calories and synthetic sweeteners, which studies show can generate excessive cravings for sweets and actually increase weight gain.

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