Simian virus 40 (SV40)

Simian virus 40 (SV40)

SV40 is an abbreviation for Simian vacuolating virus 40 or Simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors, but most often persists as a latent infection.

SV40 became a highly controversial subject after it was revealed that millions were exposed to the virus after receiving a contaminated polio vaccine.

[Source: Wikipedia]

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View the Evidence: Problem Substances

Investigation of human JC and BK polyomaviruses in breast carcinomas.

Pubmed Data : Breast Cancer Res Treat. 2012 Jun ;133(3):969-77. Epub 2011 Nov 23. PMID: 22108781
Article Published Date : May 31, 2012
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621)
Additional Keywords : Endogenous Retroviruses : CK(31) : AC(12)
Problem Substances : Mouse Mammary Tumour Viruses (MMTV) : CK(11) : AC(2), Simian virus 40 (SV40) : CK(84) : AC(16)

Simian virus 40 has a high prevalence in hematological malignancies and probably plays a role in tumor pathogenesis.

Pubmed Data : Cancer Res. 2004 Jun 1;64(11):3757-60. PMID: 15172980
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Diseases : Hematologic Diseases : CK(32) : AC(5), Leukemia : CK(670) : AC(258), Lymphoma: Non-Hodgkin : CK(256) : AC(67)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Simian virus 40 in humans.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Infect Agent Cancer. 2007 ;2:13. Epub 2007 Jul 9. PMID: 17620119
Article Published Date : Dec 31, 2006
Study Type : Human Study
Additional Links
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Simian virus 40 is found at far higher rates in breast tumors and probably contributes to pathogenesis in those tumors.

Pubmed Data : Breast Cancer Res Treat. 2009 Jan;113(1):43-58. Epub 2008 Jan 18. PMID: 18205041
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Metastasis : CK(272) : AC(135)
Additional Keywords : Oncoviruses : CK(21) : AC(3)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

SV40 is associated significantly with brain tumors, bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma.

Pubmed Data : Am J Med. 2003 Jun 1 ;114(8):675-84. PMID: 12798456
Article Published Date : Jun 01, 2003
Study Type : Human Study
Additional Links
Diseases : Bone Cancer : CK(65) : AC(39), Brain Cancer : CK(231) : AC(88), Mesothelioma : CK(30) : AC(10), Non-Hodgkin Lymphoma : CK(525) : AC(67), Simian virus 40 (SV40) : CK(7) : AC(5), Tumors : CK(197) : AC(110)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

The prevalence of antibodies against SV40 peptide (or a yet undetected closely related polyomavirus) within blood donors 18 to 65 years old is 18%.

Pubmed Data : Hum Immunol. 2012 Feb 21. Epub 2012 Feb 21. PMID: 22387152
Article Published Date : Feb 21, 2012
Study Type : Human Study
Additional Links
Diseases : Simian virus 40 (SV40) : CK(7) : AC(5)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

There is a high prevalance rate for simian virus 40 in diffuse large B-cell lymphomas in Tunisia.

Pubmed Data : Int J Cancer. 2007 Dec 15;121(12):2693-702. PMID: 17724719
Article Published Date : Dec 15, 2007
Study Type : Human Study
Additional Links
Diseases : Cancer Metastasis : CK(272) : AC(135), Lymphoma: B-Cell : CK(21) : AC(12)
Additional Keywords : Oncoviruses : CK(21) : AC(3)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Vertically transmitted viral infection and polyviral infection with BK virus, JC virus and SV40 virus are significantly more frequent among autistic patients compared to controls.

Pubmed Data : J Neurovirol. 2010 Mar 29. Epub 2010 Mar 29. PMID: 20345322
Article Published Date : Mar 29, 2010
Study Type : Human Study
Additional Links
Diseases : Autism : CK(1262) : AC(65), Autism Spectrum Disorders : CK(1140) : AC(108), Polyomavirus : CK(12) : AC(3)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Simian virus 40 efficiently infects human T lymphocytes and both extends their lifespan and alters their morphology.

Pubmed Data : Exp Hematol. 2012 Mar 12. Epub 2012 Mar 12. PMID: 22421183
Article Published Date : Mar 12, 2012
Study Type : Human In Vitro
Additional Links
Diseases : Simian virus 40 (SV40) : CK(7) : AC(5), T lymphocytes: Morphological Abnormalities : CK(5) : AC(1)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961.

Pubmed Data : Cancer Res. 2005 Nov 15 ;65(22):10273-9. PMID: 16288015
Article Published Date : Nov 15, 2005
Study Type : Human In Vitro
Additional Links
Diseases : Simian virus 40 (SV40) : CK(7) : AC(5)
Additional Keywords : Vaccine Contamination : CK(5) : AC(1)
Anti Therapeutic Actions : Vaccination: Polio : CK(94) : AC(15)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Res. 1997 Aug 1 ;57(15):3319-20. PMID: 9242467
Article Published Date : Jul 31, 1997
Study Type : Human In Vitro
Additional Links
Diseases : Simian virus 40 (SV40) : CK(7) : AC(5)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

SV40-like sequences are commonly found in human mesotheliomas and osteosarcomas.

Pubmed Data : Dev Biol Stand. 1998 ;94:33-40. PMID: 9776223
Article Published Date : Jan 01, 1998
Study Type : Human In Vitro
Additional Links
Diseases : Mesothelioma : CK(30) : AC(10), Osteosarcoma : CK(80) : AC(39), Simian virus 40 (SV40) : CK(7) : AC(5)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Simian virus 40 can induce cancers in hamsters

Pubmed Data : Dev Biol Stand. 1998 ;94:273-9. PMID: 9776247
Article Published Date : Jan 01, 1998
Study Type : Animal Study
Additional Links
Diseases : Lymphoma : CK(209) : AC(69), Mesothelioma : CK(30) : AC(10), Osteosarcoma : CK(80) : AC(39), Simian virus 40 (SV40) : CK(7) : AC(5)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Simian virus 40 infection is found within malignant mesotheliomas and mesothelial cell proliferations.

Pubmed Data : J Cell Biochem. 1999 Dec;76(2):181-8. PMID: 10618635
Article Published Date : Dec 01, 1999
Study Type : Animal Study
Additional Links
Diseases : Lung Cancer : CK(496) : AC(198), Mesothelioma : CK(30) : AC(10)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

"Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40."

Pubmed Data : Virology. 1962 May ;17:65-75. PMID: 13889129
Study Type : Viral
Additional Links
Diseases : Simian virus 40 (SV40) : CK(7) : AC(5)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

60% of mesotheliomas contain SV40 DNA sequences.

Pubmed Data : Semin Cancer Biol. 2001 Feb;11(1):73-80. PMID: 11243901
Article Published Date : Feb 01, 2001
Study Type : Commentary
Additional Links
Diseases : Mesothelioma : CK(30) : AC(10)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Cancer risk associated with simian virus 40 contaminated polio vaccine.

Pubmed Data : Anticancer Res. 1999 May-Jun;19(3B):2173-80. PMID: 10472327
Article Published Date : Apr 30, 1999
Study Type : Viral
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869), Ependymoma : CK(1) : AC(1), Mesothelioma : CK(30) : AC(10), Osteosarcoma : CK(80) : AC(39)
Additional Keywords : Vaccine Contamination : CK(5) : AC(1)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Gamma-irradiation of frozen bovine serum does not inactivate simian virus 40 adventitious viral contaminant.

Pubmed Data : PDA J Pharm Sci Technol. 2010 Sep-Oct;64(5):432-5. PMID: 21502047
Article Published Date : Aug 31, 2010
Study Type : Review
Additional Links
Additional Keywords : Adventitious Viruses : CK(18) : AC(9), Vaccine Contamination : CK(5) : AC(1)
Anti Therapeutic Actions : Gamma Irradiation: "Cold Pasteurization" : CK(18) : AC(13)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Simian virus 40 infection is associated with breast, lung, and prostate cancer subtypes of greatest malignancy.

Pubmed Data : Cancer Res. 2007 Sep 1;67(17):8065-80. PMID: 17804718
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621), Lung Cancer : CK(496) : AC(198), Prostate Cancer : CK(998) : AC(288)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Simian virus 40 infection is associated with inflammatory kidney diseases and with specific tumor types: mesothelioma, lymphoma, brain, and bone.

Pubmed Data : Virology. 2004 Jan 5;318(1):1-9. PMID: 15015494
Article Published Date : Jan 05, 2004
Study Type : Commentary
Additional Links
Diseases : Bone Cancer : CK(65) : AC(39), Brain Cancer : CK(231) : AC(88), Inflammatory Kidney Diseases : CK(3) : AC(2), Kidney Diseases : CK(424) : AC(71), Lymphoma : CK(209) : AC(69), Mesothelioma : CK(30) : AC(10)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

SV40 may act as a cofactor in the pathogenesis of some tumors.

Pubmed Data : Expert Rev Respir Med. 2011 Oct ;5(5):683-97. PMID: 21955238
Article Published Date : Oct 01, 2011
Study Type : Review
Additional Links
Diseases : Simian virus 40 (SV40) : CK(7) : AC(5), Tumors : CK(197) : AC(110)
Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)
Adverse Pharmacological Actions : Tumorigenic : CK(12) : AC(8)

SV40 works synergistically with methylcholanthrene to elicit tumors.

Pubmed Data : Cancer Cell Int. 2010;10:4. Epub 2010 Feb 23. PMID: 20178601
Article Published Date : Jan 01, 2010
Study Type : Commentary
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869)
Additional Keywords : Cellular Immortalization : CK(1) : AC(1)
Problem Substances : Methylcholanthrene : CK(1) : AC(1), Simian virus 40 (SV40) : CK(84) : AC(16)

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