Statin Drugs

Statin Drugs

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View the Evidence: Problem Substances

A combination of ezetimibe and simvastatin do not reduce aortic valve stenosis.

Pubmed Data : Am J Cardiol. 2010 Dec 1;106(11):1634-9. Epub 2010 Oct 14. PMID: 21094366
Article Published Date : Dec 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Aortic Stenosis : CK(44) : AC(11)
Problem Substances : Ezetimibe (trade name Zetia) : CK(30) : AC(2), Simvastatin : CK(723) : AC(146)

Ezetimibe and simvastatin use is associated with increased cancer incidence and death.

Pubmed Data : Heart Lung Circ. 2009 Oct;18(5):343-6. Epub 2009 Jul 7. PMID: 19586799
Article Published Date : Oct 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(9376) : AC(2939)
Problem Substances : Simvastatin : CK(723) : AC(146)
Adverse Pharmacological Actions : Carcinogenic : CK(951) : AC(135)

In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Pubmed Data : JAMA. 2011 Jun 22;305(24):2556-64. PMID: 21693744
Article Published Date : Jun 22, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(2161) : AC(359), Statin-Induced Pathologies : CK(1600) : AC(320)
Problem Substances : Statin Drugs : CK(3971) : AC(475)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Insomnia is a possible statin-associated psychiatric adverse effect.

Pubmed Data : Drug Saf. 2008;31(12):1115-23. PMID: 19026028
Article Published Date : Jan 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Insomnia : CK(471) : AC(57)
Problem Substances : Statin Drugs : CK(3971) : AC(475)

Lipid-lowering drugs contribute to erectile dysfunction.

Pubmed Data : Fam Pract. 2002 Feb ;19(1):95-8. PMID: 11818357
Article Published Date : Feb 01, 2002
Study Type : Meta Analysis
Additional Links
Diseases : Erectile Dysfunction : CK(262) : AC(44), Statin-Induced Pathologies : CK(1600) : AC(320)
Problem Substances : Cholesterol Lowering Drugs : CK(2306) : AC(370), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3971) : AC(475)

Muscle complaints occur in 10% or more of patients started on high-dose statins.

Pubmed Data : Curr Opin Lipidol. 2007 Aug;18(4):401-8. PMID: 17620856
Article Published Date : Aug 01, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Myopathies : CK(252) : AC(53)
Problem Substances : Statin Drugs : CK(3971) : AC(475)
Adverse Pharmacological Actions : Myotoxicity : CK(327) : AC(80)

Pancreatitis, while rare, is a possible side effect of taking statin drugs.

Pubmed Data : Drug Saf. 2006 ;29(12):1123-32. PMID: 17147459
Article Published Date : Jan 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Pancreatitis : CK(164) : AC(42), Statin-Induced Pathologies : CK(1600) : AC(320)
Problem Substances : Simvastatin : CK(723) : AC(146), Statin Drugs : CK(3971) : AC(475)

Pravastatin therapy was associated with an increasing risk of cancer as age increases.

Pubmed Data : CMAJ. 2007 Feb 27 ;176(5):649-54. PMID: 17325332
Article Published Date : Feb 27, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(9376) : AC(2939), Statin-Induced Pathologies : CK(1600) : AC(320)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(140)
Problem Substances : Pravastatin : CK(239) : AC(40)
Adverse Pharmacological Actions : Carcinogenic : CK(951) : AC(135)

Simvastatin contributes to insulin resistance in non-diabetic patients.

Pubmed Data : Diabetes Res Clin Pract. 2010 Jan ;87(1):98-107. Epub 2009 Nov 12. PMID: 19913318
Article Published Date : Jan 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(2161) : AC(359), Hyperglycemia : CK(300) : AC(67), Insulin Resistance : CK(1121) : AC(235)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(140)
Problem Substances : Simvastatin : CK(723) : AC(146)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(150) : AC(36)

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations.

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996
Article Published Date : Sep 14, 2011
Study Type : Meta Analysis
Additional Links
Diseases : AST: Elevated : CK(26) : AC(4), Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(2161) : AC(359), Elevated: ALT : CK(23) : AC(2), Elevated: Creatinine Kinase : CK(33) : AC(3), GGT : CK(73) : AC(10)
Problem Substances : Atorvastatin : CK(513) : AC(97), Statin Drugs : CK(3971) : AC(475)
Adverse Pharmacological Actions : Hepatotoxic : CK(301) : AC(85)

Statin drugs increase the risk of diabetes.

Pubmed Data : Curr Opin Cardiol. 2011 Jul;26(4):342-7. PMID: 21499090
Article Published Date : Jul 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(892) : AC(235), Drug-Induced Toxicity : CK(560) : AC(82), Statin-Induced Pathologies : CK(1600) : AC(320)
Problem Substances : Statin Drugs : CK(3971) : AC(475)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Statin use is associated with an increased incidence of interstitial lung disease.

Pubmed Data : Chest. 2008 Oct;134(4):824-30. Epub 2008 Aug 8. PMID: 18689579
Article Published Date : Oct 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Hyperlipidemia : CK(534) : AC(115), Interstitial Lung Diseases : CK(70) : AC(12)
Problem Substances : Statin Drugs : CK(3971) : AC(475)

Statins are not associated with a reduced risk of pneumonia.

Pubmed Data : Eur J Clin Pharmacol. 2011 Nov 15. Epub 2011 Nov 15. PMID: 22083167
Article Published Date : Nov 15, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Pneumonia : CK(330) : AC(40)
Problem Substances : Statin Drugs : CK(3971) : AC(475)

Statins may partially operate by lowering testosterone.

Pubmed Data : BMC Med. 2013 Feb 28 ;11(1):57. Epub 2013 Feb 28. PMID: 23448151
Article Published Date : Feb 27, 2013
Study Type : Meta Analysis
Additional Links
Diseases : Testosterone: Too Low : CK(401) : AC(73)
Problem Substances : Statin Drugs : CK(3971) : AC(475)
Adverse Pharmacological Actions : Endocrine Disruptor: Testes : CK(1) : AC(1)

The use of statins for LDL suppression is associated with increased risk for cancer.

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
Article Published Date : Jul 31, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(9376) : AC(2939), Chemically-Induced Liver Damage : CK(500) : AC(187), High Cholesterol : CK(1226) : AC(199), Statin-Induced Pathologies : CK(1600) : AC(320)
Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(723) : AC(146), Statin Drugs : CK(3971) : AC(475)
Adverse Pharmacological Actions : Carcinogenic : CK(951) : AC(135)

There are 17 randomized trials on statin treatment showing an increased incidence of diabetes.

Pubmed Data : QJM. 2010 Oct 7. Epub 2010 Oct 7. PMID: 20934984
Article Published Date : Oct 07, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Blood Sugar Problems : CK(4475) : AC(752), Diabetes Mellitus: Type 1 : CK(892) : AC(235), Diabetes Mellitus: Type 2 : CK(2161) : AC(359)
Problem Substances : Statin Drugs : CK(3971) : AC(475)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Concomitant use of erythromycin and simvastatin may increase the cataract risk.

Pubmed Data : Arch Intern Med. 2001 Sep 10 ;161(16):2021-6. PMID: 11525705
Article Published Date : Sep 10, 2001
Study Type : Human Study
Additional Links
Diseases : Cataract : CK(182) : AC(57), Statin-Induced Pathologies : CK(1600) : AC(320)
Pharmacological Actions : Anti-Bacterial Agents : CK(979) : AC(321)
Problem Substances : Simvastatin : CK(723) : AC(146), Statin Drugs : CK(3971) : AC(475)

Forty-five of 358 statin-treated patients demonstrated a 15% increase in LDL cholesterol levels, leading to suspicion of statin escape phenomenon.

Pubmed Data : Eur J Intern Med. 2005 Jun ;16(3):192-194. PMID: 15967335
Article Published Date : Jun 01, 2005
Study Type : Human Study
Additional Links
Diseases : Statin-Induced Pathologies : CK(1600) : AC(320)
Problem Substances : Statin Drugs : CK(3971) : AC(475)

"High antiphospholipid antibody levels are associated with statin use and may reflect chronic endothelial damage in non-autoimmune thrombosis."

Pubmed Data : J Clin Pathol. 2012 Mar 3. Epub 2012 Mar 3. PMID: 22389514
Article Published Date : Mar 03, 2012
Study Type : Human Study
Additional Links
Diseases : Endothelial Damage : CK(31) : AC(10), Thrombosis : CK(295) : AC(74)
Problem Substances : Statin Drugs : CK(3971) : AC(475)

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Are Statins Worth the Risk?
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Cholesterol lowering drugs called Statins generated $34 billion in sales in 2007 and have raked in over a quarter of a trillion dollars since they were introduced two decades ago. A new study reported in the NY Times links the use of statins with a higher risk of developing diabetes.

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