Statin Drugs

Statin Drugs

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View the Evidence: Problem Substances

A combination of ezetimibe and simvastatin do not reduce aortic valve stenosis.

Pubmed Data : Am J Cardiol. 2010 Dec 1;106(11):1634-9. Epub 2010 Oct 14. PMID: 21094366
Article Published Date : Dec 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Aortic Stenosis : CK(44) : AC(11)
Problem Substances : Ezetimibe (trade name Zetia) : CK(30) : AC(2), Simvastatin : CK(713) : AC(143)

Ezetimibe and simvastatin use is associated with increased cancer incidence and death.

Pubmed Data : Heart Lung Circ. 2009 Oct;18(5):343-6. Epub 2009 Jul 7. PMID: 19586799
Article Published Date : Oct 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Carcinogenic : CK(936) : AC(130)

In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Pubmed Data : JAMA. 2011 Jun 22;305(24):2556-64. PMID: 21693744
Article Published Date : Jun 22, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3507) : AC(341), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Insomnia is a possible statin-associated psychiatric adverse effect.

Pubmed Data : Drug Saf. 2008;31(12):1115-23. PMID: 19026028
Article Published Date : Jan 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Insomnia : CK(471) : AC(56)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

Lipid-lowering drugs contribute to erectile dysfunction.

Pubmed Data : Fam Pract. 2002 Feb ;19(1):95-8. PMID: 11818357
Article Published Date : Feb 01, 2002
Study Type : Meta Analysis
Additional Links
Diseases : Erectile Dysfunction : CK(510) : AC(41), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3969) : AC(465)

Muscle complaints occur in 10% or more of patients started on high-dose statins.

Pubmed Data : Curr Opin Lipidol. 2007 Aug;18(4):401-8. PMID: 17620856
Article Published Date : Aug 01, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Myopathies : CK(252) : AC(51)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Pancreatitis, while rare, is a possible side effect of taking statin drugs.

Pubmed Data : Drug Saf. 2006 ;29(12):1123-32. PMID: 17147459
Article Published Date : Jan 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Pancreatitis : CK(164) : AC(40), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Pravastatin therapy was associated with an increasing risk of cancer as age increases.

Pubmed Data : CMAJ. 2007 Feb 27 ;176(5):649-54. PMID: 17325332
Article Published Date : Feb 27, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Pravastatin : CK(239) : AC(40)
Adverse Pharmacological Actions : Carcinogenic : CK(936) : AC(130)

Simvastatin contributes to insulin resistance in non-diabetic patients.

Pubmed Data : Diabetes Res Clin Pract. 2010 Jan ;87(1):98-107. Epub 2009 Nov 12. PMID: 19913318
Article Published Date : Jan 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3507) : AC(341), Hyperglycemia : CK(3073) : AC(59), Insulin Resistance : CK(1034) : AC(221)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations.

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996
Article Published Date : Sep 14, 2011
Study Type : Meta Analysis
Additional Links
Diseases : AST: Elevated : CK(26) : AC(4), Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3507) : AC(341), Elevated: ALT : CK(23) : AC(2), Elevated: Creatinine Kinase : CK(33) : AC(3), GGT : CK(73) : AC(10)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Statin drugs increase the risk of diabetes.

Pubmed Data : Curr Opin Cardiol. 2011 Jul;26(4):342-7. PMID: 21499090
Article Published Date : Jul 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1173) : AC(218), Drug-Induced Toxicity : CK(560) : AC(78), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Statin use is associated with an increased incidence of interstitial lung disease.

Pubmed Data : Chest. 2008 Oct;134(4):824-30. Epub 2008 Aug 8. PMID: 18689579
Article Published Date : Oct 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Hyperlipidemia : CK(1221) : AC(109), Interstitial Lung Diseases : CK(70) : AC(12)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

Statins are not associated with a reduced risk of pneumonia.

Pubmed Data : Eur J Clin Pharmacol. 2011 Nov 15. Epub 2011 Nov 15. PMID: 22083167
Article Published Date : Nov 15, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Pneumonia : CK(330) : AC(40)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

Statins may partially operate by lowering testosterone.

Pubmed Data : BMC Med. 2013 Feb 28 ;11(1):57. Epub 2013 Feb 28. PMID: 23448151
Article Published Date : Feb 27, 2013
Study Type : Meta Analysis
Additional Links
Diseases : Testosterone: Too Low : CK(369) : AC(70)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Endocrine Disruptor: Testes : CK(1) : AC(1)

The use of statins for LDL suppression is associated with increased risk for cancer.

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
Article Published Date : Jul 31, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869), Chemically-Induced Liver Damage : CK(489) : AC(175), High Cholesterol : CK(1718) : AC(198), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Carcinogenic : CK(936) : AC(130)

There are 17 randomized trials on statin treatment showing an increased incidence of diabetes.

Pubmed Data : QJM. 2010 Oct 7. Epub 2010 Oct 7. PMID: 20934984
Article Published Date : Oct 07, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Blood Sugar Problems : CK(4378) : AC(729), Diabetes Mellitus: Type 1 : CK(1173) : AC(218), Diabetes Mellitus: Type 2 : CK(3507) : AC(341)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Concomitant use of erythromycin and simvastatin may increase the cataract risk.

Pubmed Data : Arch Intern Med. 2001 Sep 10 ;161(16):2021-6. PMID: 11525705
Article Published Date : Sep 10, 2001
Study Type : Human Study
Additional Links
Diseases : Cataract : CK(182) : AC(55), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Forty-five of 358 statin-treated patients demonstrated a 15% increase in LDL cholesterol levels, leading to suspicion of statin escape phenomenon.

Pubmed Data : Eur J Intern Med. 2005 Jun ;16(3):192-194. PMID: 15967335
Article Published Date : Jun 01, 2005
Study Type : Human Study
Additional Links
Diseases : Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

"High antiphospholipid antibody levels are associated with statin use and may reflect chronic endothelial damage in non-autoimmune thrombosis."

Pubmed Data : J Clin Pathol. 2012 Mar 3. Epub 2012 Mar 3. PMID: 22389514
Article Published Date : Mar 03, 2012
Study Type : Human Study
Additional Links
Diseases : Endothelial Damage : CK(31) : AC(10), Thrombosis : CK(657) : AC(74)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

Related Blogs

Do the New Guidelines for Statins Make Sense?
Written by Dr. Michael Murray
Under the current guidelines, statins are recommended for about 15 percent of adults. With the new guidelines 44 percent of men and 22 percent of women would meet the criteria for taking a statin. Is this good, evidence-based medicine or misguided?
Statin Drugs Linked To Worsening Osteoarthritis Of The Knee
Written by Sayer Ji, Founder
New research flies in the face of a new theory that statin drugs, used to lower cholesterol, may be of value in those suffering from osteoarthritis. To the contrary, statin drugs are likely contributing to the epidemic of knee osteoarthritis in exposed populations.
Chocolate Gives Statins A $29 Billion Run For Their Money
Written by Sayer Ji, Founder
With the cholesterol-lowering class of drugs known as statins being widely promoted for the primary prevention of cardiovascular disease, despite their having over 300 documented adverse health effects (including heart failure!), how does chocolate sound as a viable, heart-friendly alternative?

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