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Statin Drugs

Statin Drugs

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View the Evidence: Problem Substances

In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Pubmed Data : JAMA. 2011 Jun 22;305(24):2556-64. PMID: 21693744
Article Published Date : Jun 22, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Simvastatin contributes to insulin resistance in non-diabetic patients.

Pubmed Data : Diabetes Res Clin Pract. 2010 Jan ;87(1):98-107. Epub 2009 Nov 12. PMID: 19913318
Article Published Date : Jan 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperglycemia : CK(2892) : AC(59), Insulin Resistance : CK(1034) : AC(221)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Statin drugs increase the risk of diabetes.

Pubmed Data : Curr Opin Cardiol. 2011 Jul;26(4):342-7. PMID: 21499090
Article Published Date : Jul 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Drug-Induced Toxicity : CK(560) : AC(78), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

There are 17 randomized trials on statin treatment showing an increased incidence of diabetes.

Pubmed Data : QJM. 2010 Oct 7. Epub 2010 Oct 7. PMID: 20934984
Article Published Date : Oct 07, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Blood Sugar Problems : CK(4050) : AC(693), Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Rosuvastatin treatment is associated with an increase in insulin resistance in hyperlipidaemic patients with impaired fasting glucose.

Pubmed Data : Int J Clin Pract. 2009 Sep ;63(9):1308-13. PMID: 19691613
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hyperlipidemia : CK(1211) : AC(109), Insulin Resistance : CK(1034) : AC(221), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Rosuvastatin : CK(68) : AC(16)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Statin medication use in postmenopausal women is associated with an increased risk for diabetes.

Pubmed Data : Arch Intern Med. 2012 Jan 23 ;172(2):144-52. Epub 2012 Jan 9. PMID: 22231607
Article Published Date : Jan 23, 2012
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Statin therapy is associated with 14% increased risk of type 2 diabetes.

Pubmed Data : Diabetes Care. 2012 Dec 17. Epub 2012 Dec 17. PMID: 23248196
Article Published Date : Dec 16, 2012
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8)
Problem Substances : Atorvastatin : CK(491) : AC(90), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Acute onset and worsening of diabetes concurrent with administration of statins has been reported.

Pubmed Data : Endocr J. 2005 Jun ;52(3):369-72. PMID: 16006732
Article Published Date : Jun 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : A1C : CK(253) : AC(35), Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90), Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

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