Sucralose

Sucralose

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Article Count - 10
Cumulative Knowledge - 28

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What is Cumulative Knowledge?

Cumulative Knowledge is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.

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Quick Summary: 6 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Immune Disorders: Low Immune Function	2	1	Log in \| Sign up
Crohn's Disease	1	1	Log in \| Sign up
DNA damage	1	1	Log in \| Sign up
Inflammatory Bowel Diseases	1	1	Log in \| Sign up
Migraine Disorders	1	1	Log in \| Sign up
Ulcerative Colitis	1	1	Log in \| Sign up

Quick Summary: 1 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Inflammatory	1	1	Log in \| Sign up

View the Evidence: Problem Substances

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load.

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Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524

Article Published Date : Apr 29, 2013

Study Type : Human Study

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Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Insulin Resistance : CK(1034) : AC(221)

Problem Substances : Sucralose : CK(15) : AC(10)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Sucralose causes bowel enlargement, kidney mineralization and abnormal pelvic tissue changes in rats.

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Pubmed Data : Food Chem Toxicol. 1990 Jun;28(6):449-55. PMID: 2210518

Article Published Date : Jun 01, 1990

Study Type : Animal Study

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Problem Substances : Sucralose : CK(15) : AC(10)

Sucralose has been demonstrated to be carcinogenic and otherwise toxic in rats.

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Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S71-89. PMID: 10882819

Article Published Date : Jan 01, 2000

Study Type : Animal Study

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Problem Substances : Sucralose : CK(15) : AC(10)

Sucralose reduces the weight of spleen and thymus in rats.

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Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S53-69. PMID: 10882818

Article Published Date : Aug 01, 2005

Study Type : Animal Study

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Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115)

Problem Substances : Sucralose : CK(15) : AC(10)

Sucralose represents an ecotoxicological contaminant that significantly affects the behavior of animals.

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Pubmed Data : Chemosphere. 2012 Jan ;86(1):50-5. Epub 2011 Sep 28. PMID: 21955350

Article Published Date : Jan 01, 2012

Study Type : Animal Study

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Additional Keywords : Environmental Pollutant : CK(32) : AC(15), Environmental Toxicity : CK(6) : AC(4)

Problem Substances : Sucralose : CK(15) : AC(10)

The administration of Splenda (sucralose) to rats at a dose far below the US FDA Acceptable Daily intake for sucralose exhibited numerous adverse effects in the gastrointesintal tract of male rats.

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Pubmed Data : J Toxicol Environ Health A. 2008;71(21):1415-29. PMID: 18800291

Article Published Date : Jan 01, 2008

Study Type : Animal Study

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Problem Substances : Sucralose : CK(15) : AC(10)

two-week supplementation of a low carbohydrate diet with sucralose, saccharin or acesulfame-K up-regulated intestinal SGLT1 expression levels to

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Pubmed Data : Proc Natl Acad Sci U S A. 2007 Sep 18 ;104(38):15075-80. Epub 2007 Aug 27. PMID: 17724332

Article Published Date : Sep 17, 2007

Study Type : Animal Study

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Additional Keywords : cephalic phase effect

Problem Substances : Acesulfame potassium : CK(22) : AC(8), Saccharin : CK(18) : AC(7), Sucralose : CK(15) : AC(10)

Increased sucralose consumption may explain why Canada has the highest incidence of inflammatory bowel disease in the world.

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Pubmed Data : Can J Gastroenterol. 2011 Sep ;25(9):511. PMID: 21912763

Article Published Date : Sep 01, 2011

Study Type : Review

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Diseases : Crohn's Disease : CK(122) : AC(22), Inflammatory Bowel Diseases : CK(1227) : AC(103), Ulcerative Colitis : CK(429) : AC(39)

Problem Substances : Sucralose : CK(15) : AC(10)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Sucralose consumption may contribute to inflammatory bowel disease.

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Pubmed Data : World J Gastroenterol. 2012 Apr 21 ;18(15):1708-22. PMID: 22553395

Article Published Date : Apr 21, 2012

Study Type : Review

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Diseases : Clostridium Enterocolitis : CK(1) : AC(1), Crohn's Disease : CK(122) : AC(22), Inflammatory Bowel Diseases : CK(1227) : AC(103)

Problem Substances : Sucralose : CK(15) : AC(10)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Sucralose is found in drinking water tested with a low rate of removal (11%) and serving 28 million people.

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Pubmed Data : Environ Sci Technol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21879743

Article Published Date : Aug 31, 2011

Study Type : Review

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Problem Substances : Sucralose : CK(15) : AC(10)

Sucralose is largely resistant to natural breakdown processes and accumulates in the environment with unknown consequences for human and environmental health.

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Pubmed Data : Environ Sci Technol. 2011 Jan 14. [Epub ahead of print]. PMID: 21235203

Study Type : In Vitro Study

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Problem Substances : Sucralose : CK(15) : AC(10)

Sucralose may be a migraine trigger.

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Pubmed Data : Headache. 2006 Sep;46(8):1303-4. PMID: 16942478

Article Published Date : Sep 01, 2006

Study Type : Commentary

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Diseases : Migraine Disorders : CK(486) : AC(58)

Problem Substances : Sucralose : CK(15) : AC(10)

Various food additives, preservatives, fungicides and artificial sweeteners have been demonstrated to have the potential to damage DNA in gastrointestinal organs.

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Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896

Article Published Date : Aug 26, 2002

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Biphenyl : CK(1) : AC(1), Butylated hydroxyanisole (BHA) : CK(9) : AC(7), Butylated Hydroxytoluene (BHT) : CK(74) : AC(44), Saccharin : CK(18) : AC(7), Sodium Cyclamate : CK(15) : AC(4), Sodium o-phenylphenol : CK(1) : AC(1), Sucralose : CK(15) : AC(10), Thiabendazole : CK(1) : AC(1)

Related Blogs

Splenda (Sucralose) Found To Have Diabetes-Promoting Effects

Written by Sayer Ji, Founder

Promoted for decades as a "safe" sugar alternative, presumably to prevent or reduce symptoms of diabetes, Splenda (sucralose) has been found to have diabetes-promoting effects in human subjects.

Have We Stripped Our Food Of Its Story?

Written by Sayer Ji & Tania Melkonian

Food has lost its story. Stripped of context, meaning, and reduced to its molecular composition, ancient recipes for health and joy long to be recovered.

Sweet! Dieting without Deprivation

Written by Sayer Ji, Founder

So, you are looking to lose a few pounds, or keep them off. What better way to accomplish this feat than to eliminate both empty sugar calories and synthetic sweeteners, which studies show can generate excessive cravings for sweets and actually increase weight gain.

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