Tamoxifen

Tamoxifen

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Tamoxifen is a Sub of the following Topic

Quick Summary: Current access displays 2 out of 29 associated Diseases
NameCumulative KnowledgeArticle CountFocus Articles
Endometrial Cancer11615Log in | Sign up
Breast Cancer9311Log in | Sign up
View the Evidence: Problem Substances

Five or more years of tamoxifen use increases risk of cataracts in breast cancer patients.

Pubmed Data : Breast Cancer Res Treat. 2000 Mar;60(2):167-72. PMID: 10845279
Article Published Date : Mar 01, 2000
Study Type : Meta Analysis
Additional Links
Diseases : Cataract : CK(175) : AC(55), Drug-Induced Toxicity : CK(538) : AC(78)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)

Tamoxifen interferes with cognitive function in breast cancer patients.

Pubmed Data : Breast Cancer Res Treat. 2000 Nov;64(2):165-76. PMID: 11194452
Article Published Date : Nov 01, 2000
Study Type : Meta Analysis
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Drug-Induced Toxicity : CK(538) : AC(78), Memory Disorders: Drug-Induced : CK(74) : AC(12)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Tamoxifen use may cause endometrial cancer, as well as being associated with poorer prognosis.

Pubmed Data : Int J Cancer. 1998 May 4;76(3):325-30. PMID: 9579567
Article Published Date : May 04, 1998
Study Type : Meta Analysis
Additional Links
Diseases : Endometrial Cancer : CK(260) : AC(45)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Two year treatment with Tamoxifen and Arimidex result in a number of side effects which reduce quality of life.

Pubmed Data : Breast Cancer Res Treat. 2006 Dec;100(3):273-84. Epub 2006 Jun 21. PMID: 16944295
Article Published Date : Dec 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity : CK(538) : AC(78)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Arimidex : CK(122) : AC(12), Tamoxifen : CK(296) : AC(39)

Adjuvant tamoxifen therapy for early stage breast cancer increases the risk of second primarly malignancies such as endometrial, colon and somatch cancer.

Pubmed Data : J Natl Cancer Inst. 1995 May 3;87(9):645-51. PMID: 7752269
Article Published Date : May 03, 1995
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Colorectal Cancer : CK(809) : AC(303), Endometrial Cancer : CK(260) : AC(45), Gastric Cancer : CK(381) : AC(111)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.

Pubmed Data : J Psychosoc Oncol. 2011 Sep-Oct;29(5):499-514. PMID: 21882931
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity : CK(692) : AC(184), Memory Disorders: Drug-Induced : CK(74) : AC(12), Memory Loss : CK(113) : AC(32)
Anti Therapeutic Actions : Chemotherapy : CK(248) : AC(36)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Tamoxifen and Arimidex (anastrozole) can have detrimental effects on higher brain funtions.

Pubmed Data : J Clin Exp Neuropsychol. 2010 Mar 24:1-11. Epub 2010 Mar 24. PMID: 20336566
Article Published Date : Mar 24, 2010
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Cognitive Decline/Dysfunction : CK(514) : AC(87)
Problem Substances : Arimidex : CK(122) : AC(12), Tamoxifen : CK(296) : AC(39)

Tamoxifen and raloxifene adversely affect cognitive function in older women.

Pubmed Data : J Womens Health (Larchmt). 2010 Mar ;19(3):371-9. PMID: 20136553
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)
Anti Therapeutic Actions : Chemotherapy : CK(248) : AC(36)
Problem Substances : Raloxifene : CK(103) : AC(11), Tamoxifen : CK(296) : AC(39)

Tamoxifen causes DNA adducs in the endometrium of women.

Pubmed Data : Carcinogenesis. 2000 Aug;21(8):1461-7. PMID: 10910945
Article Published Date : Aug 01, 2000
Study Type : Human Study
Additional Links
Diseases : Endometrial Cancer : CK(260) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110), Genotoxic : CK(109) : AC(50), Mutagenic : CK(22) : AC(11)

Tamoxifen has been shown to cause endometrial cancer in humans.

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):105-10. PMID: 11267730
Article Published Date : Mar 01, 2001
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Endometrial Cancer : CK(260) : AC(45)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Tamoxifen increases the risk of endometrial hyperplasia and carcinoma in breast cancer patients.

Pubmed Data : Vopr Onkol. 2003;49(2):198-204. PMID: 12785205
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Endometrial Cancer : CK(260) : AC(45)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Tamoxifen may induce fatty liver in patients with breast cancer.

Pubmed Data : AJR Am J Roentgenol. 2003 Jan;180(1):129-34. PMID: 12490491
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Fatty Liver : CK(490) : AC(118)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Hepatotoxic : CK(266) : AC(73)

Tamoxifen therapy has been associated with the development of acute myeloid leukemia during breast cancer treatment.

Pubmed Data : Med Oncol. 1997 Mar;14(1):61-2. PMID: 9232614
Article Published Date : Mar 01, 1997
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Tamoxifen treatment for breast cancer in Japanese women results in an increased risk for endomentrial and stomach cancer.

Pubmed Data : Ann Oncol. 2000 Dec;11(12):1537-43. PMID: 11205460
Article Published Date : Dec 01, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Endometrial Cancer : CK(260) : AC(45), Gastric Cancer : CK(381) : AC(111)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Tamoxifen treatment for breast cancer may result in fatty liver.

Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(453) : AC(175), Fatty Liver : CK(490) : AC(118)
Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Drug: Doxorubicin : CK(140) : AC(54), Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Hepatotoxic : CK(266) : AC(73)

Tamoxifen treatment for breast cancer results in one-third of all patients developing endometrial polyps, hyperplasia, metaplasia, consistent with an estrogen-agonist effect.

Pubmed Data : Gynecol Oncol. 2000 Aug;78(2):181-6. PMID: 10926800
Article Published Date : Aug 01, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Endometrial Cancer : CK(260) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Estrogen Agonist : CK(13) : AC(4), Estrogenic : CK(51) : AC(12)

Tamoxifen treatment in breast cancer may induce non-alcoholic fatty liver.

Pubmed Data : Intern Med. 2002 May;41(5):345-50. PMID: 12058881
Article Published Date : May 01, 2002
Study Type : Human Study
Additional Links
Diseases : Fatty Liver : CK(490) : AC(118)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Hepatotoxic : CK(266) : AC(73)

Tamoxifen treatment increases the risk of endometrial cancer in both premenopausal and postmenopausal women

Pubmed Data : J Natl Cancer Inst. 2005 Mar 2;97(5):375-84. PMID: 15741574
Article Published Date : Mar 02, 2005
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Endometrial Cancer : CK(260) : AC(45)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Tamoxifen treatment results in adverse structural and functional changes in the brain in women.

Pubmed Data : Neuroimage. 2004 Jan;21(1):364-71. PMID: 14741674
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity : CK(538) : AC(78), Memory Disorders: Drug-Induced : CK(74) : AC(12)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Tamoxifen usage is associated with bone loss in patients who continued to menstruate after adjuvant chemotherapy.

Pubmed Data : J Clin Oncol. 2006 Feb 1;24(4):675-80. PMID: 16446340
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Diseases : Osteoporosis : CK(1090) : AC(205)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)

Tamoxifen use is associated with increased risk for endomentrial polyps and cancer.

Pubmed Data : Gynecol Obstet Fertil. 2005 Dec;33(12):975-9. PMID: 16321556
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Endometrial Cancer : CK(260) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogen : CK(59) : AC(11)

The widespread use of tamoxifen as a preventive agent against breast cancer in healthy women may result in significantly elevated levels of endometrial cancer.

Pubmed Data : Lancet. 2000 Sep 9;356(9233):881-7. PMID: 11036892
Article Published Date : Sep 09, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer : CK(2051) : AC(566), Endometrial Cancer : CK(260) : AC(45)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Women treated with tamoxifen in the adjuvant setting experienced symptoms of sexual dysfunction.

Pubmed Data : J Clin Oncol. 1999 May;17(5):1488-92. PMID: 10334535
Article Published Date : May 01, 1999
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity : CK(538) : AC(78), Sexual Dysfunction : CK(74) : AC(13)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)

Sesame seeds should be avoided during Tamoxifen therapy.

Pubmed Data : Exp Biol Med (Maywood). 2007 Jun;232(6):754-61. PMID: 17526767
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sesame Seeds : CK(151) : AC(27)
Diseases : Breast Cancer: Conventional Treatment : CK(2) : AC(1)
Additional Keywords : Drug/Natural Substance Contraindications : CK(3) : AC(2)
Problem Substances : Tamoxifen : CK(296) : AC(39)

Tamoxifen causes DNA damage in multiple organs of adult femaile cynomolgus monkeys.

Pubmed Data : Cancer Res. 2003 Sep 15;63(18):5999-6003. PMID: 14522927
Article Published Date : Sep 15, 2003
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(680) : AC(293)
Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)
Problem Substances : Tamoxifen : CK(296) : AC(39)
Adverse Pharmacological Actions : Genotoxic : CK(109) : AC(50)

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