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Thyroxine
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Additional Topics Details for this Page
Article Count
- 15
Cumulative Knowledge
- 121
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Quick Summary: Current access displays 2 out of 16 associated Diseases
Name
Cumulative Knowledge
Article Count
Focus Articles
Hypothyroidism
50
5
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Hypoglycemia
20
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Quick Summary: 2 associated Adverse Pharmacological Actions
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Oxidant
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View the Evidence: Problem Substances
"Levothyroxine Medication is Associated with Adiposity Independent of TSH.
Click here to read the entire abstract
Pubmed Data
: Exp Clin Endocrinol Diabetes. 2012 May 25. Epub 2012 May 25. PMID:
22639395
Article Published Date
: May 25, 2012
Study Type
: Human Study
Additional Links
Diseases
:
Overweight : CK(2176) : AC(342)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
Among adults aged 70 or more, current levothyroxine treatment was associated with a significantly increased risk of fracture, with a strong dose-response relation.
Click here to read the entire abstract
Pubmed Data
: BMJ. 2011;342:d2238. Epub 2011 Apr 28. PMID:
21527461
Article Published Date
: Jan 01, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Bone Fractures : CK(1610) : AC(69)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
Bisphosphonates are less effective in women receiving TSH-suppressing doses of thyroxine.
Click here to read the entire abstract
Pubmed Data
: Thyroid. 2009 May;19(5):437-42. PMID:
19415993
Article Published Date
: May 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity: L-Thyroxine : CK(23) : AC(8)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
,
Thyroxine : CK(104) : AC(15)
Dessicated thyroid (Armour) has been associated with superior clinical outcomes compared to levothyroxine in the treatment of hypothyroidism.
Click here to read the entire abstract
Pubmed Data
: Altern Med Rev. 2004 Jun;9(2):157-79. PMID:
15253676
Article Published Date
: Jun 01, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Hypothyroidism : CK(537) : AC(78)
Additional Keywords
:
Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
In hypothyroid patients L-T4-replacement, that is sufficient to maintain a normal serum TSH, is accompanied by a serum free T4 that is higher than that in untreated euthyroid patients or normal individuals and may not result in an appropriately normal ser
Click here to read the entire abstract
Pubmed Data
: J Endocrinol Invest. 2002 Feb ;25(2):106-9. PMID:
11929079
Article Published Date
: Feb 01, 2002
Study Type
: Human Study
Additional Links
Diseases
:
Hypothyroidism : CK(537) : AC(78)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
Increasing levels of free thyroxine as a risk factor for a first venous thrombosis.
Click here to read the entire abstract
Pubmed Data
: Blood. 2010 Jun 3;115(22):4344-9. Epub 2010 Mar 22. PMID:
20308594
Article Published Date
: Jun 03, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Venous Thrombosis : CK(30) : AC(3)
Problem Substances
:
Thyroxine : CK(104) : AC(15)
Levothyroxine administration is associated with altered fibrinolysis and coagulation, indicating it may increase the risk of venous thrombosis.
Click here to read the entire abstract
Pubmed Data
: J Thromb Haemost. 2011 Jul 5. Epub 2011 Jul 5. PMID:
21729238
Article Published Date
: Jul 05, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Deep Vein Thrombosis : CK(511) : AC(10)
,
Thrombosis : CK(657) : AC(74)
,
Venous Thrombosis : CK(30) : AC(3)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
Levothyroxine may be a risk factor for hypoglycaemia in patients with liver disease.
Click here to read the entire abstract
Pubmed Data
: J Clin Pharm Ther. 2003 Oct;28(5):355-61. PMID:
14632959
Article Published Date
: Oct 01, 2003
Study Type
: Human Study
Additional Links
Diseases
:
Hypoglycemia : CK(274) : AC(21)
,
Hypothyroidism : CK(537) : AC(78)
,
Liver Disease : CK(112) : AC(31)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
Levothyroxine replacement therapy increases coagulation (fibrinogen) following initiation of treatment.
Click here to read the entire abstract
Pubmed Data
: J Endocrinol Invest. 2005 May;28(5):398-404. PMID:
16075920
Article Published Date
: May 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Blood Coagulation Disorders : CK(42) : AC(8)
,
Drug-Induced Toxicity : CK(560) : AC(78)
,
Fibrinogen: Elevated : CK(114) : AC(13)
,
Hypothyroidism : CK(537) : AC(78)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
Levothyroxine use is associated with increased risk of hypoglycemia in patients with liver impairment.
Click here to read the entire abstract
Pubmed Data
: Int J Clin Pharmacol Ther. 2008 Jan;46(1):1-13. PMID:
18218292
Article Published Date
: Jan 01, 2008
Study Type
: Human Study
Additional Links
Diseases
:
Hypoglycemia : CK(274) : AC(21)
,
Hypothyroidism : CK(537) : AC(78)
,
Liver Disease : CK(112) : AC(31)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
Thyroid hormone replacement therapy may result in acute delerium in patients with primary hypothyroidism.
Click here to read the entire abstract
Pubmed Data
: Thyroid. 2005 Sep;15(9):1099-101. PMID:
16187922
Article Published Date
: Sep 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Delerium: Acute : CK(10) : AC(1)
,
Hypothyroidism : CK(537) : AC(78)
Problem Substances
:
Levothyroxine : CK(92) : AC(10)
L-thyroxine increases oxidative stress in rat renal cortex.
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2011 Feb;38(2):1047-54. Epub 2010 Jun 24. PMID:
20574713
Article Published Date
: Feb 01, 2011
Study Type
: Animal Study
Additional Links
Problem Substances
:
Thyroxine : CK(104) : AC(15)
Adverse Pharmacological Actions
:
Nephrotoxic : CK(162) : AC(38)
L-thyroxine induces enhanced oxidative stress and oxygen consumption in the hyperthyroid rat liver.
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2008 May 28;173(2):105-14. Epub 2008 Mar 10. PMID:
18377885
Article Published Date
: May 28, 2008
Study Type
: Animal Study
Additional Links
Diseases
:
Oxidative Stress : CK(1945) : AC(710)
Problem Substances
:
Thyroxine : CK(104) : AC(15)
Adverse Pharmacological Actions
:
Oxidant : CK(104) : AC(37)
L-thyroxine induces oxidative stress in the rat testicle.
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2008 Nov 25;176(2-3):121-8. Epub 2008 Aug 3. PMID:
18723006
Article Published Date
: Nov 25, 2008
Study Type
: Animal Study
Additional Links
Diseases
:
Drug-Induced Toxicity: L-Thyroxine : CK(23) : AC(8)
,
Oxidative Stress : CK(1945) : AC(710)
Problem Substances
:
Thyroxine : CK(104) : AC(15)
Adverse Pharmacological Actions
:
Oxidant : CK(104) : AC(37)
Synthetic thyroxine products are below 100% purity.
Click here to read the entire abstract
Pubmed Data
: Arch Pharm Res. 2010 Sep;33(9):1419-23. Epub 2010 Oct 14. PMID:
20945141
Article Published Date
: Sep 01, 2010
Study Type
: Animal Study
Additional Links
Problem Substances
:
D-Thyroxine : CK(2) : AC(1)
,
Levothyroxine : CK(92) : AC(10)
Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biol Chem. 2011 May 6 ;286(18):16163-73. Epub 2011 Feb 16. PMID:
21325280
Article Published Date
: May 05, 2011
Study Type
: In Vitro Study
Additional Links
Additional Keywords
:
thyroxine conformation
Problem Substances
:
Thyroxine : CK(104) : AC(15)
Review: Thyroid hormone-induced oxidative stress.
Click here to read the entire abstract
Pubmed Data
: Cell Mol Life Sci. 2006 Feb;63(4):414-34. PMID:
16389448
Article Published Date
: Feb 01, 2006
Study Type
: Review
Additional Links
Diseases
:
Drug-Induced Toxicity: L-Thyroxine : CK(23) : AC(8)
,
Hyperthyroidism : CK(189) : AC(33)
,
Lipid Peroxidation : CK(403) : AC(127)
,
Oxidative Stress : CK(1945) : AC(710)
Problem Substances
:
Thyroxine : CK(104) : AC(15)
Adverse Pharmacological Actions
:
Oxidant : CK(104) : AC(37)
TSH suppression therapy with thyroxine replacement does not significantly improve the condition of those with low-risk thyroid cancer.
Click here to read the entire abstract
Pubmed Data
: Nat Clin Pract Endocrinol Metab. 2005 Nov;1(1):32-40. PMID:
16929364
Article Published Date
: Nov 01, 2005
Study Type
: Review
Additional Links
Diseases
:
Thyroid Cancer : CK(162) : AC(32)
Problem Substances
:
Thyroxine : CK(104) : AC(15)
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