Trans Fatty Acids

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View the Evidence: Problem Substances

Consumption of trans-fatty acids from partially hydrogenated oils adversely affects multiple cardiovascular risk factors and contributes significantly to increased risk of oronary heart disease events.

Pubmed Data : Eur J Clin Nutr. 2009 May;63 Suppl 2:S5-21. PMID: 19424218
Article Published Date : May 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173), Inflammation : CK(1077) : AC(363), Insulin Resistance : CK(1034) : AC(221), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Dietary intake of trans fatty acids is associated with increase in the risk of coronary artery disease.

Pubmed Data : Ann Nutr Metab. 2008;52(1):24-8. Epub 2008 Jan 30. PMID: 18230967
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

High consumption of trans-fatty acids is associated with an increased risk of colorectal cancer.

Pubmed Data : Am J Epidemiol. 2008 Aug 1;168(3):289-97. Epub 2008 Jun 27. PMID: 18587137
Article Published Date : Aug 01, 2008
Study Type : Human Study
Additional Links
Diseases : Colorectal Cancer : CK(877) : AC(321)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

High consumption of trans-fatty acids was positively associated with distal colorectal cancer among Whites.

Pubmed Data : Cancer Causes Control. 2010 Jan;21(1):171-80. Epub 2009 Oct 20. PMID: 19842051
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Colorectal Cancer : CK(877) : AC(321)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

High trans fat consumption remains a significant risk factor for coronary heart disease.

Pubmed Data : Circulation. 2007 Apr 10;115(14):1858-65. Epub 2007 Mar 26. PMID: 17389261
Article Published Date : Apr 10, 2007
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136)
Problem Substances : Trans Fatty Acids : CK(281) : AC(39)

Higher intake of hydrogenated fats may increase the risk of Alzheimer disease.

Pubmed Data : Arch Neurol. 2003 Feb;60(2):194-200. PMID: 12580703
Article Published Date : Feb 01, 2003
Study Type : Human Study
Additional Links
Diseases : Alzheimer's Disease : CK(886) : AC(160)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

Industrially produced trans fatty acids increase tumor necrosis factor, an indicator of systemic inflammation.

Pubmed Data : J Lipid Res. 2011 Jul 27. Epub 2011 Jul 27. PMID: 21795740
Article Published Date : Jul 27, 2011
Study Type : Human Study
Additional Links
Diseases : Experimental Lung Inflammation : CK(361) : AC(1)
Problem Substances : Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Tumor necrosis factorα (TNFα) up-regulation : CK(42) : AC(4)

Intake of trans-fatty acids contributes to a sizeable proportion of coronary heart disease events in Iran.

Pubmed Data : Eur J Clin Nutr. 2007 Aug;61(8):1004-10. Epub 2007 Jan 31. PMID: 17268422
Article Published Date : Aug 01, 2007
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

The consumption of hydrogenated oil is associated with systemic inflammation and endothelial function.

Pubmed Data : Atheroscler Suppl. 2006 May;7(2):29-32. Epub 2006 May 18. PMID: 16713393
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Diseases : Arteriosclerosis : CK(2154) : AC(123), Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173), Inflammation : CK(1077) : AC(363)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

The consumption of trans fatty acids is associated with increased risk for sudden cardiac death in women.

Pubmed Data : Am Heart J. 2009 Nov;158(5):761-7. Epub 2009 Sep 22. PMID: 19853694
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality : CK(703) : AC(67)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

The intake of partially hydrogenated vegetable oils may contribute to the risk of myocardial infarction.

Pubmed Data : Circulation. 1994 Jan;89(1):94-101. PMID: 8281700
Article Published Date : Jan 01, 1994
Study Type : Human Study
Additional Links
Diseases : Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

The intake of trans fatty acids and risk of coronary heart disease among women.

Pubmed Data : Lancet. 1993 Mar 6;341(8845):581-5. PMID: 8094827
Article Published Date : Mar 06, 1993
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Hypertension : CK(2783) : AC(271)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

There is a higher content of 18:1 trans fatty acids in subcutaneous fat of persons with coronarographically documented atherosclerosis of the coronary arteries.

Pubmed Data : Ann Nutr Metab. 2003;47(6):302-5. PMID: 14520026
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136)
Problem Substances : Trans Fatty Acids : CK(281) : AC(39)

Topical hydrogenated castor oil has been reported to cause severe contact dermatitis.

Pubmed Data : Dermatitis. 2009 Dec;20(6):E16-20. PMID: 19958732
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Problem Substances : Hydrogenated Castor Oil : CK(12) : AC(2)

Trans fatty acid consumption has been linked to increased aggression and irritability in humans.

Pubmed Data : PLoS One. 2012 ;7(3):e32175. Epub 2012 Mar 5. PMID: 22403632
Article Published Date : Jan 01, 2012
Study Type : Human Study
Additional Links
Diseases : Aggression : CK(143) : AC(15), Psychiatric Disorder: Aggression : CK(50) : AC(5)
Problem Substances : Trans Fatty Acids : CK(281) : AC(39)

Trans-fatty acid levels in the blood are associated with increased risk of prostate cancer.

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):95-101. PMID: 18199715
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : Prostate Cancer : CK(998) : AC(288)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

Hydrogenated castor oil has been shown to be toxic in experimental animals.

Pubmed Data : J Toxicol Sci. 1993 Aug;18 Suppl 3:1-9. PMID: 7505032
Article Published Date : Aug 01, 1993
Study Type : Animal Study
Additional Links
Problem Substances : Hydrogenated Castor Oil : CK(12) : AC(2)

Hydrogenated oil decreases concentrations of n-6 polyunsaturated fatty acids and may contribute to dyschondroplasia in broilers.

Pubmed Data : Br Poult Sci. 1991 Dec;32(5):1109-19. PMID: 1786572
Article Published Date : Dec 01, 1991
Study Type : Animal Study
Additional Links
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

Hydrogenated oil may compete with the metabolism of normal polyunsaturated fatty acids and may adversely alter liver phospholipids.

Pubmed Data : Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4830-4. PMID: 2052561
Article Published Date : Jun 01, 1991
Study Type : Animal Study
Additional Links
Problem Substances : Hydrogenated Oil : CK(148) : AC(23)

Intake of trans fatty acid-rich hydrogenated fat during pregnancy and lactation inhibits the appetite suppressing effects of central insulin in the adult offspring.

Pubmed Data : Nutrition. 2006 Jul-Aug;22(7-8):820-9. PMID: 16815496
Article Published Date : Jul 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Trans Fatty Acids : CK(281) : AC(39)

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In the first study of its kind researchers have linked trans fatty acid consumption to increased aggression in humans. Published in the Public Library of Science’s own journal, PLoS, March 5th 2012, researchers at the Dept. of Medicine at the University of California, San Diego, reported: "This study provides the first evidence linking dTFA [dietary trans fatty acids] with behavioral irritability and aggression."

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