Tylenol

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View the Evidence: Problem Substances

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.

Pubmed Data : Am J Med. 2010 Mar;123(3):231-7. PMID: 20193831
Article Published Date : Mar 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(82), Hearing Loss : CK(100) : AC(23)
Problem Substances : Aspirin : CK(487) : AC(68), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1588) : AC(134), Tylenol : CK(125) : AC(13)

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.

Pubmed Data : Cochrane Database Syst Rev. 2002(2):CD003676. PMID: 12076499
Article Published Date : Jan 01, 2002
Study Type : Meta Analysis
Additional Links
Diseases : Fever : CK(87) : AC(14)
Problem Substances : Paracetamol : CK(44) : AC(6), Tylenol : CK(125) : AC(13)

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe.

Pubmed Data : Transfus Med Rev. 2007 Jan;21(1):1-12. PMID: 17174216
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Blood Transfusion : CK(60) : AC(4)
Problem Substances : Diphenhydramine : CK(72) : AC(9), Tylenol : CK(125) : AC(13)

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.

Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Autism Spectrum Disorders : CK(1354) : AC(112)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1588) : AC(134), Tylenol : CK(125) : AC(13)

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.

Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Febrile Seizures : CK(83) : AC(5), Fever : CK(87) : AC(14)
Problem Substances : Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1588) : AC(134), Paracetamol : CK(44) : AC(6), Tylenol : CK(125) : AC(13)

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(9):e108210. Epub 2014 Sep 24. PMID: 25251831
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity : CK(283) : AC(31), Prenatal Chemical Exposures : CK(384) : AC(92)
Problem Substances : Paracetamol : CK(44) : AC(6), Tylenol : CK(125) : AC(13)

Chronic tylenol use is associated wtih an almost two-fold increased risk of blood cancer.

Pubmed Data : J Clin Oncol. 2011 May 9. Epub 2011 May 9. PMID: 21555699
Article Published Date : May 09, 2011
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Leukemia: Chronic Lymphocytic Leukemia (CLL) : CK(56) : AC(27), Lymphoma : CK(210) : AC(69)
Problem Substances : Tylenol : CK(125) : AC(13)
Adverse Pharmacological Actions : Carcinogenic : CK(951) : AC(135)

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran

Pubmed Data : Z Gastroenterol. 2009 Sep;47(9):807-13. Epub 2009 Sep 11. PMID: 19750427
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Chemically-Induced Liver Damage : CK(500) : AC(187)
Problem Substances : Tylenol : CK(125) : AC(13)

Over the counter cold medications manufactured for children can result in toxicity that can lead to death when given to infants.

Pubmed Data : J Anal Toxicol. 2005 Oct;29(7):738-43. PMID: 16419411
Article Published Date : Oct 01, 2005
Study Type : Human Study
Additional Links
Diseases : Cold and Flu: Infants & Children : CK(62) : AC(6), Infant Mortality : CK(249) : AC(25)
Problem Substances : Brompheniramine : CK(10) : AC(1), Carbinoxamine : CK(10) : AC(1), Chlorpheniramine : CK(10) : AC(1), Cold Medications : CK(10) : AC(1), Dextromethorphan : CK(10) : AC(1), Diphenhydramine : CK(72) : AC(9), Ephedrine : CK(10) : AC(1), Ethanol : CK(22) : AC(7), Levorphanol : CK(10) : AC(1), Metoclopramide : CK(10) : AC(1), Pseudoephedrine : CK(10) : AC(1), Tylenol : CK(125) : AC(13)

Tylenol may have lethal side effects in children.

Pubmed Data : Cas Lek Cesk. 2007;146(4):401-5; discussion 405-6. PMID: 17491251
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Problem Substances : Tylenol : CK(125) : AC(13)

Tylenol use has been linked to unexplained dyspepsia.

Pubmed Data : Dig Dis Sci. 1988 Jun;33(6):641-8. PMID: 3371135
Article Published Date : Jun 01, 1988
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Dyspepsia : CK(174) : AC(22)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1588) : AC(134), Tylenol : CK(125) : AC(13)

This case highlights the significant morbidity that can occur with even unintentional APAP toxicity and the need to educate patients, especially pregnant patients, of the risk of excessive APAP use.

Pubmed Data : . PMID: 22415886
 
Article Published Date : Mar 13, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Liver Failure: Drug Induced : CK(23) : AC(3)
Problem Substances : Tylenol : CK(125) : AC(13)

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium.

Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469
Article Published Date : Jan 05, 2007
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Uranium Poisoning : CK(28) : AC(20)
Additional Keywords : Toxic Substance Synergy : CK(5) : AC(3)
Problem Substances : Tylenol : CK(125) : AC(13), Uranium : CK(46) : AC(22)
Adverse Pharmacological Actions : Hepatotoxic : CK(301) : AC(85), Nephrotoxic : CK(177) : AC(42)

Sesamol protects against acetaminophen-induced injury in animals.

Pubmed Data : Shock. 2009 Jul ;32(1):89-93. PMID: 18948843
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol : CK(54) : AC(31)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Chemically-Induced Liver Damage : CK(500) : AC(187), Lipid Peroxidation : CK(459) : AC(144), Liver Damage : CK(660) : AC(226), Oxidative Stress : CK(2855) : AC(750)
Pharmacological Actions : Antioxidants : CK(5301) : AC(1618), Hepatoprotective : CK(632) : AC(282)
Problem Substances : Tylenol : CK(125) : AC(13)
Adverse Pharmacological Actions : Hepatotoxic : CK(301) : AC(85), Oxidant : CK(107) : AC(40)

Tribulus extract has a hepatoprotective effect against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus).

Pubmed Data : In Vitro Cell Dev Biol Anim. 2011 Dec ;47(10):698-706. PMID: 21975853
Article Published Date : Nov 30, 2011
Study Type : Animal Study
Additional Links
Substances : Tribulus : CK(57) : AC(28)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30)
Pharmacological Actions : Antioxidants : CK(5301) : AC(1618), Hepatoprotective : CK(632) : AC(282)
Additional Keywords : Plant Extracts : CK(5359) : AC(1705)
Problem Substances : Tylenol : CK(125) : AC(13)
Adverse Pharmacological Actions : Hepatotoxic : CK(301) : AC(85)

Autism can be triggered by acetaminophen activation of the endocannabinoid system.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Neurobiol Exp (Wars). 2010;70(2):227-31. PMID: 20628445
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(104) : AC(30), Autism Spectrum Disorders : CK(1354) : AC(112), Endocannabinoid Disorders : CK(15) : AC(9)
Additional Keywords : Diseases that are Linked : CK(2142) : AC(272)
Problem Substances : Tylenol : CK(125) : AC(13)
Adverse Pharmacological Actions : Neurotoxic : CK(1155) : AC(201)

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