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Article Count - 13
Cumulative Knowledge - 130

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Quick Summary: Current access displays 2 out of 18 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Acetaminophen (Tylenol) Toxicity	55	8	Log in \| Sign up
Fever	30	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 5 associated Adverse Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Carcinogenic	10	1	Log in \| Sign up
Hepatotoxic	4	2	Log in \| Sign up

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View the Evidence: Problem Substances

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.

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Pubmed Data : Am J Med. 2010 Mar;123(3):231-7. PMID: 20193831

Article Published Date : Mar 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Hearing Loss : CK(97) : AC(24)

Problem Substances : Aspirin : CK(471) : AC(64), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Tylenol : CK(125) : AC(13)

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.

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Pubmed Data : Cochrane Database Syst Rev. 2002(2):CD003676. PMID: 12076499

Article Published Date : Jan 01, 2002

Study Type : Meta Analysis

Additional Links

Diseases : Fever : CK(77) : AC(14)

Problem Substances : Paracetamol : CK(44) : AC(6), Tylenol : CK(125) : AC(13)

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe.

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Pubmed Data : Transfus Med Rev. 2007 Jan;21(1):1-12. PMID: 17174216

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Blood Transfusion : CK(60) : AC(4)

Problem Substances : Diphenhydramine : CK(72) : AC(9), Tylenol : CK(125) : AC(13)

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.

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Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737

Article Published Date : May 01, 2008

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Autism Spectrum Disorders : CK(1140) : AC(108)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Tylenol : CK(125) : AC(13)

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.

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Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Febrile Seizures : CK(83) : AC(5), Fever : CK(77) : AC(14)

Problem Substances : Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Paracetamol : CK(44) : AC(6), Tylenol : CK(125) : AC(13)

Chronic tylenol use is associated wtih an almost two-fold increased risk of blood cancer.

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Pubmed Data : J Clin Oncol. 2011 May 9. Epub 2011 May 9. PMID: 21555699

Article Published Date : May 09, 2011

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Leukemia: Chronic Lymphocytic Leukemia (CLL) : CK(51) : AC(23), Lymphoma : CK(209) : AC(69)

Problem Substances : Tylenol : CK(125) : AC(13)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran

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Pubmed Data : Z Gastroenterol. 2009 Sep;47(9):807-13. Epub 2009 Sep 11. PMID: 19750427

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175)

Problem Substances : Tylenol : CK(125) : AC(13)

Over the counter cold medications manufactured for children can result in toxicity that can lead to death when given to infants.

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Pubmed Data : J Anal Toxicol. 2005 Oct;29(7):738-43. PMID: 16419411

Article Published Date : Oct 01, 2005

Study Type : Human Study

Additional Links

Diseases : Cold and Flu: Infants & Children : CK(62) : AC(6), Infant Mortality : CK(229) : AC(23)

Problem Substances : Brompheniramine : CK(10) : AC(1), Carbinoxamine : CK(10) : AC(1), Chlorpheniramine : CK(10) : AC(1), Cold Medications : CK(10) : AC(1), Dextromethorphan : CK(10) : AC(1), Diphenhydramine : CK(72) : AC(9), Ephedrine : CK(10) : AC(1), Ethanol : CK(21) : AC(7), Levorphanol : CK(10) : AC(1), Metoclopramide : CK(10) : AC(1), Pseudoephedrine : CK(10) : AC(1), Tylenol : CK(125) : AC(13)

Tylenol may have lethal side effects in children.

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Pubmed Data : Cas Lek Cesk. 2007;146(4):401-5; discussion 405-6. PMID: 17491251

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Problem Substances : Tylenol : CK(125) : AC(13)

Tylenol use has been linked to unexplained dyspepsia.

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Pubmed Data : Dig Dis Sci. 1988 Jun;33(6):641-8. PMID: 3371135

Article Published Date : Jun 01, 1988

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Dyspepsia : CK(422) : AC(21)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Tylenol : CK(125) : AC(13)

This case highlights the significant morbidity that can occur with even unintentional APAP toxicity and the need to educate patients, especially pregnant patients, of the risk of excessive APAP use.

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Pubmed Data : . PMID: 22415886

Article Published Date : Mar 13, 2012

Study Type : Human: Case Report

Additional Links

Diseases : Liver Failure: Drug Induced : CK(23) : AC(3)

Problem Substances : Tylenol : CK(125) : AC(13)

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium.

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Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469

Article Published Date : Jan 05, 2007

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Uranium Poisoning : CK(28) : AC(19)

Additional Keywords : Toxic Substance Synergy : CK(5) : AC(3)

Problem Substances : Tylenol : CK(125) : AC(13), Uranium : CK(46) : AC(21)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Nephrotoxic : CK(162) : AC(38)

Sesamol protects against acetaminophen-induced injury in animals.

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Pubmed Data : Shock. 2009 Jul ;32(1):89-93. PMID: 18948843

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Sesamol : CK(79) : AC(30)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175), Lipid Peroxidation : CK(403) : AC(127), Liver Damage : CK(597) : AC(213), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Problem Substances : Tylenol : CK(125) : AC(13)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Oxidant : CK(104) : AC(37)

Tribulus extract has a hepatoprotective effect against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus).

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Pubmed Data : In Vitro Cell Dev Biol Anim. 2011 Dec ;47(10):698-706. PMID: 21975853

Article Published Date : Nov 30, 2011

Study Type : Animal Study

Additional Links

Substances : Tribulus : CK(50) : AC(23)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Problem Substances : Tylenol : CK(125) : AC(13)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Autism can be triggered by acetaminophen activation of the endocannabinoid system.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Neurobiol Exp (Wars). 2010;70(2):227-31. PMID: 20628445

Article Published Date : Jan 01, 2010

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Autism Spectrum Disorders : CK(1140) : AC(108), Endocannabinoid Disorders : CK(15) : AC(9)

Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Tylenol : CK(125) : AC(13)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

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