Wheat

Despite popular opinion wheat consumption may not be beneficial to health. These two published articles make a strong argument against perceiving wheat intolerance as simply a matter of allergy/genetic intolerance in a minority subset of the human population, but rather as a species-specific intolerance, applicable to all.

Part 1: The Dark Side of Wheat: New Perspectives on Celiac Disease & Wheat Intolerance

Part 2: Opening Pandora’s Bread Box: The Critical Role of Wheat Lectin in Human Disease.

Below are peer-reviewed studies connecting wheat consumption with over 200 adverse health effects and 20 modes of toxicity.

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Quick Summary: 232 associated Diseases
NameCumulative KnowledgeArticle CountFocus Articles
Celiac Disease1607170 |
Gluten Sensitivity89674 |
Autoimmune Diseases13612 |
Schizophrenia1218 |
Food Allergies: Wheat11612 |
Food Allergies9710 |
Diabetes Mellitus: Type 1: Prevention8212 |
Psoriasis825 |
Irritable Bowel Syndrome815 |
Down Syndrome805 |
Diabetes Mellitus: Type 17914 |
Autism Spectrum Disorders747 |
Celiac Disease: Diagnostic Considerations637 |
Celiac Disease: Prevalance 627 |
Sjogren's Syndrome603 |
Cerebellar Ataxia534 |
Osteoporosis533 |
Dermatitis Herpetiformis504 |
Epilepsy506 |
Graves Disease503 |
Liver Disease502 |
Multiple Myeloma503 |
Multiple Sclerosis503 |
Migraine Disorders445 |
Casein Intolerance433 |
Infertility413 |
Atherosclerosis402 |
Atopic Dermatitis404 |
Gastroesophageal Reflux402 |
Hyperthyroidism402 |
Infertility: Female402 |
Anaphylaxis: Exercise-Induced375 |
IgA Nephropathy363 |
Gastrointestinal Inflammation345 |
Autism333 |
Miscarriage: Recurrent313 |
Autoimmune Thyroiditis302 |
Cirrhosis: Liver301 |
Diarrhea: IBS associated301 |
Dysbiosis303 |
Gluten Ataxia302 |
Hepatitis: Autoimmune 302 |
Hypothyroidism303 |
IgA rheumatoid factor: elevated302 |
Non-Hodgkin Lymphoma303 |
Polyarthritis301 |
Psychoses301 |
Intestinal Permeability 288 |
Eosinophilic esophagitis264 |
Epilepsy: With Cerebral Calcifications253 |
Ataxia: Cerebellar244 |
Cerebral Calcifications232 |
Diarrhea233 |
Celiac Disease: Prevention222 |
Abortion: Spontaneous212 |
Thyroid Nodule212 |
Aphthous Ulcer202 |
Attention Deficit Disorder with Hyperactivity202 |
Attention Deficit Hyperactivity Disorder201 |
Cardiomyopathy201 |
Cholestasis201 |
Cholestasis: Autoimmune201 |
Coronary Artery Disease201 |
Cryptogenic Hypertransaminasemia201 |
Dental Enamel Defects202 |
End-Stage Autoimmune Liver Disease (ESALD)201 |
Fibromyalgia201 |
Hashimoto's thyroiditis201 |
Hyperexcitable brain and refractory coeliac disease201 |
Hypertransaminasemia202 |
IgE-Mediated Hypersensitivity202 |
Infant Nutrition201 |
Meniere's Disease201 |
Organ Transplantation: Liver201 |
Palmoplantar Pustulosis201 |
Peripheral Neuropathies201 |
Restless Legs Syndrome202 |
Rett Syndrome201 |
Sensory Neuropathies201 |
Stomatitis: Aphthous202 |
Macroamylasemia 194 |
Neuromyelitis Optica163 |
Hyperinsulinism153 |
Ataxia143 |
Insulin: Elevated143 |
Demyelinating Diseases133 |
Headache132 |
Pancreatitis132 |
Uveitis132 |
Gluten Enteropathy122 |
Lymphoma122 |
Psychiatric Disorders122 |
Rheumatoid Arthritis123 |
Baker's Asthma112 |
Cancers: All112 |
Insulin Resistance112 |
Thyroid Cancer112 |
Acquired hypogammaglobulinemia101 |
All-Cause Mortality101 |
Allergy: Cow's Milk 101 |
Anaphylaxis101 |
Ataxia: Dominant101 |
Ataxia: Sporadic101 |
Atopic Dermatitis: Infant & Childhood101 |
Atrial Fibrillation101 |
Attention Deficit Disorder101 |
Brain Injury: Hippocampal Damage101 |
CNS White Matter Abnormalities 101 |
Carpal Tunnel Syndrome101 |
Celiac Disease: Early Onset101 |
Child Mortality 101 |
Children: Impaired Growth101 |
Chronic Constipation, Children101 |
Chronic Obstructive Pulmonary Disease101 |
Colitis: Collagenous101 |
Constipation101 |
Depression101 |
Diarrhea: in Children 101 |
Dysmotility-Like Dyspepsia101 |
Enamel Defects101 |
Epithelium Damage: Lymphocytic infiltration 101 |
Food Allergies/Intolerances: Cereals/Grains101 |
Gastrointestinal Hemorrhage101 |
Hippocampal Sclerosis 101 |
Hypogammaglobulinemia101 |
Kidney Cancer101 |
Lichen Planus101 |
Liver Fibrosis101 |
Mania: Acute101 |
Microscopic Colitis Syndrome101 |
Mortality: All-Cause101 |
Mucosa: Flattened101 |
Myocarditis: Autoimmune101 |
Myopathies101 |
Myopathies: Inflammatory101 |
Nervous System Diseases101 |
Neurological Illness: GAD antibody-associated101 |
Nightshade Foods Intolerance101 |
Pregnancy: Prevention of Problems101 |
Small-for-gestational-age infant101 |
Spinocerebellar Ataxia Type 2101 |
Stiff-Person Syndrome101 |
Temporal Lobe Epilepsy (TLE)101 |
Thyroid Neoplasms101 |
Turner Syndrome101 |
Urinary Stone Disease101 |
Kidney Diseases92 |
Prolactin: Inappropriate Secretion82 |
Anemia72 |
Cerebral Hypoperfusion61 |
Conjunctival Tumor61 |
Ectopic Calcification61 |
Encephalopathies61 |
Glomerulonephritis61 |
Hypocalcemia61 |
Idiopathic Parkinson Disease61 |
Parkinson's61 |
Parkinsonian Disorders61 |
Parkinsonism61 |
Pituitary Diseases61 |
Polyneuropathies61 |
Prolactin Hypersecretion Syndrome62 |
Schizophrenic Disorders61 |
Seizures61 |
Splenic Calcifications61 |
Splenic Diseases61 |
Systemic Lupus Erythematosus61 |
Urticaria62 |
Immune Disorders: Low Immune Function51 |
Malabsorption Syndrome 52 |
Asthma42 |
Breastfeeding Concerns: Chemical Exposure41 |
Breastfeeding: Complications41 |
Enteropathy42 |
Male Hormone Imbalances41 |
Pregnancy Complications41 |
Diabetes Mellitus: Type 231 |
Epidermolysis Bullosa31 |
Facial Palsy31 |
Folic Acid/Folate Deficiency31 |
Food Allergy: Immunoglobulin E-mediated 31 |
Gastrointestinal Diseases32 |
Hydronephrosis31 |
Hyperamylasemia31 |
Inflammation32 |
Insulin Disorders32 |
Kidney Stones31 |
Opiate Addiction/Withdrawal31 |
Osteogenesis Imperfecta31 |
Osteomalacia31 |
Osteopenia31 |
Parathyroid Diseases31 |
Parathyroid adenoma31 |
Selective IgM deficiency (sIGMD)31 |
Stroke31 |
Thrombosis31 |
Tremor31 |
Urolithiasis31 |
A1C21 |
Allergies21 |
Blood-Brain-Barrier Disorders22 |
Diabetes: Glycation/A1C21 |
Drug Toxicity: Methotrexate21 |
Glucagon: Excess Secretion21 |
Gynecomastia21 |
HPA Axis Dysregulation21 |
Insulinitis21 |
Low Immune Function: Thymus Dysfunction21 |
Metabolic Syndrome X21 |
Overweight 21 |
Serotonin Disorders21 |
Thymus Atrophy21 |
Ataxia: Idiopathic11 |
Brain: Microglial Activation11 |
Breast Cancer11 |
Chorea11 |
Clotting11 |
Dementia11 |
Food Allergy: Egg11 |
Food Poisoning11 |
Guillain-Barre Syndrome11 |
Huntington Disease11 |
Lane-Hamilton syndrome11 |
Lectin-Induced Toxicity11 |
Miscarriage11 |
Mycotoxicity11 |
Myelopathy11 |
Neurologic Disorders11 |
Neuropathy11 |
Non-coeliac gluten sensitivity (NCGS)11 |
Osteoarthritis11 |
Oxidative Stress11 |

View the Evidence: Problem Substances

Pubmed Data : Evid Based Med. 2012 Aug 4. Epub 2012 Aug 4. PMID: 22864373
Study Type : Meta Analysis

Pubmed Data : Dig Dis Sci. 2008 Nov;53(11):2925-8. Epub 2008 Mar 27. PMID: 18368491
Study Type : Meta Analysis

Pubmed Data : Cochrane Database Syst Rev. 2004(2):CD003498. PMID: 15106205
Study Type : Meta Analysis

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Yonsei Med J. 2011 May ;52(3):488-94. PMID: 21488193
Study Type : Human Study
Additional Links
Problem Substances : Wheat : CK(2765) : AC(334)

Pubmed Data : J Pediatr Gastroenterol Nutr. 2011 Aug ;53(2):145-9. PMID: 21788754
Study Type : Human Study

Pubmed Data : Przegl Lek. 2009 ;66(3):126-9. PMID: 19689036
Study Type : Human Study

Pubmed Data : Gastroenterology. 1980 Nov ;79(5 Pt 1):801-6. PMID: 7419003
Study Type : Human Study

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(3):e33387. Epub 2012 Mar 14. PMID: 22432018
Study Type : Human Study
Additional Links
Problem Substances : Wheat : CK(2765) : AC(334)

Pubmed Data : Ann Neurol. 2008 Sep ;64(3):332-43. PMID: 18825674
Study Type : Human Study
Additional Links
Problem Substances : Gliadin : CK(819) : AC(116)
Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergy Asthma Immunol Res. 2011 Jan ;3(1):53-7. Epub 2010 Nov 23. PMID: 21217926
Study Type : Human Study

Pubmed Data : Eur J Pediatr. 2011 Sep ;170(9):1173-8. Epub 2011 Feb 25. PMID: 21347849
Study Type : Human Study

Pubmed Data : Scand J Gastroenterol. 2012 Apr 19. Epub 2012 Apr 19. PMID: 22512436
Study Type : Human Study

Pubmed Data : Br J Nutr. 2012 May ;107(10):1526-33. Epub 2011 Sep 20. PMID: 21929833
Study Type : Human Study

Pubmed Data : Nutr Neurosci. 2010 Apr;13(2):87-100. PMID: 20406576
Study Type : Human Study

Pubmed Data : J Gastroenterol Hepatol. 2008 Sep ;23(9):1368-72. PMID: 18853995
Study Type : Human Study

Pubmed Data : Clin Nephrol. 1990 Feb;33(2):72-86. PMID: 2311308
Study Type : Human Study

Pubmed Data : Acta Derm Venereol. 2003;83(6):425-9. PMID: 14690336
Study Type : Human Study

Pubmed Data : Nutr Neurosci. 2012 Mar ;15(2):85-91. PMID: 22564339
Study Type : Human Study

Pubmed Data : Pediatr Diabetes. 2011 Jun ;12(4 Pt 1):322-5. Epub 2011 Mar 29. PMID: 21615651
Study Type : Human Study

Pubmed Data : Turk J Gastroenterol. 2009 Jun ;20(2):87-92. PMID: 19530040
Study Type : Human Study

Pubmed Data : Ann Neurol. 2001 Apr;49(4):540-3. PMID: 11310636
Study Type : Human Study



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