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Zoledronic Acid
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Additional Topics Details for this Page
Article Count
- 13
Cumulative Knowledge
- 65
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Related Topics
Zoledronic Acid is a Sub of the following Topics
Bisphosphonates
Osteoporosis Drugs
What is Cumulative Knowledge?
Cumulative Knowledge
is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.
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Quick Summary: Current access displays 2 out of 11 associated Diseases
Name
Cumulative Knowledge
Article Count
Focus Articles
Kidney Damage: Drug-Induced
14
3
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Osteonecrosis
14
3
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Quick Summary: Current access displays 2 out of 4 associated Adverse Pharmacological Actions
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Nephrotoxic
13
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Hepatotoxic
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View the Evidence: Problem Substances
42.4% of those who receive intravenous zoledronic acid experience adverse events of mild to moderate severity.
Click here to read the entire abstract
Pubmed Data
: J Clin Endocrinol Metab. 2010 Sep;95(9):4380-7. Epub 2010 Jun 16. PMID:
20554708
Article Published Date
: Sep 01, 2010
Study Type
: Human Study
Additional Links
Problem Substances
:
Bisphosphonates : CK(496) : AC(61)
,
Zoledronic Acid : CK(69) : AC(13)
Bisphosphonates have been linked to osteonecrosis and osteopetrosis of the jaws.
Click here to read the entire abstract
Pubmed Data
: J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75. PMID:
16243172
Article Published Date
: Nov 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Osteonecrosis : CK(112) : AC(16)
,
Osteopetrosis : CK(22) : AC(3)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
,
Bisphosphonates : CK(496) : AC(61)
,
Pamidronate : CK(33) : AC(6)
,
Zoledronic Acid : CK(69) : AC(13)
Zoledronic acid may cause renal toxicity in 37.7% of patients with multiple myeloma.
Click here to read the entire abstract
Pubmed Data
: J Cancer Res Ther. 2010 Jan-Mar;6(1):31-5. PMID:
20479544
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Kidney Damage : CK(120) : AC(42)
,
Multiple Myeloma : CK(156) : AC(53)
Problem Substances
:
Zoledronic Acid : CK(69) : AC(13)
Zolendronic acid has been associated with hand ostearthritis and arthralgia.
Click here to read the entire abstract
Pubmed Data
: Osteoporos Int. 2009 Nov 21. Epub 2009 Nov 21. PMID:
19936866
Article Published Date
: Nov 21, 2009
Study Type
: Human Study
Additional Links
Problem Substances
:
Zoledronic Acid : CK(69) : AC(13)
Zolendronic acid results in renal impairment in 23,8% of the prostate cancer patients it is administered to.
Click here to read the entire abstract
Pubmed Data
: Cancer. 2007 Mar 15;109(6):1090-6. PMID:
17311345
Article Published Date
: Mar 15, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Kidney Damage: Drug-Induced : CK(86) : AC(22)
,
Prostate Cancer : CK(998) : AC(288)
Problem Substances
:
Bisphosphonates : CK(496) : AC(61)
,
Zoledronic Acid : CK(69) : AC(13)
Adverse Pharmacological Actions
:
Nephrotoxic : CK(162) : AC(38)
A case of acute kidney injury related to intravenous zoledronic acid in a patient with multiple myeloma has been reported.
Click here to read the entire abstract
Pubmed Data
: Nippon Jinzo Gakkai Shi. 2009;51(5):557-62. PMID:
19715164
Article Published Date
: Jan 01, 2009
Study Type
: Human: Case Report
Additional Links
Diseases
:
Kidney Damage: Drug-Induced : CK(86) : AC(22)
Additional Keywords
:
Drug: Doxorubicin : CK(141) : AC(55)
Problem Substances
:
Bisphosphonates : CK(496) : AC(61)
,
Dexamethasone : CK(49) : AC(8)
,
Zoledronic Acid : CK(69) : AC(13)
Adverse Pharmacological Actions
:
Nephrotoxic : CK(162) : AC(38)
Jaw avascular osteonecrosis after treatment of multiple myeloma with zoledronate has been reported.
Click here to read the entire abstract
Pubmed Data
: J Plast Reconstr Aesthet Surg. 2008;61(1):99-106. Epub 2006 Sep 12. PMID:
18068658
Article Published Date
: Jan 01, 2008
Study Type
: Human: Case Report
Additional Links
Diseases
:
Osteonecrosis : CK(112) : AC(16)
Problem Substances
:
Bisphosphonates : CK(496) : AC(61)
,
Zoledronic Acid : CK(69) : AC(13)
Post-surgery severe hypocalcemia in primary hyperparathyroidism preoperatively treated with zoledronic acid has been reported.
Click here to read the entire abstract
Pubmed Data
: Hormones (Athens). 2010 Oct;9(4):338-42. PMID:
21112866
Article Published Date
: Oct 01, 2010
Study Type
: Human: Case Report
Additional Links
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
,
Hypocalcemia : CK(7) : AC(3)
Problem Substances
:
Zoledronic Acid : CK(69) : AC(13)
Zolendronic acid causes oxidative stress in the rabbit liver.
Click here to read the entire abstract
Pubmed Data
: Transplant Proc. 2010 Nov;42(9):3820-2. PMID:
21094863
Article Published Date
: Nov 01, 2010
Study Type
: Animal Study
Additional Links
Diseases
:
Chemically-Induced Liver Damage : CK(475) : AC(175)
Problem Substances
:
Zoledronic Acid : CK(69) : AC(13)
Adverse Pharmacological Actions
:
Hepatotoxic : CK(283) : AC(80)
,
Oxidant : CK(104) : AC(37)
Bisphosphonates are associated with a wide range of adverse health effects.
Click here to read the entire abstract
Pubmed Data
: Hormones (Athens). 2009 Apr-Jun;8(2):96-110. PMID:
19570737
Article Published Date
: Apr 01, 2009
Study Type
: Review
Additional Links
Diseases
:
Osteopenia : CK(207) : AC(41)
,
Osteoporosis : CK(1171) : AC(205)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
,
Bisphosphonates : CK(496) : AC(61)
,
Ibandronate : CK(2) : AC(2)
,
Risedronate : CK(4) : AC(3)
,
Zoledronic Acid : CK(69) : AC(13)
Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts.
Click here to read the entire abstract
Pubmed Data
: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):5-13. Epub 2008 May 27. PMID:
18504149
Article Published Date
: Jul 01, 2008
Study Type
: In Vitro Study
Additional Links
Diseases
:
Osteoporosis : CK(1171) : AC(205)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
,
Bisphosphonates : CK(496) : AC(61)
,
Zoledronic Acid : CK(69) : AC(13)
Adverse Pharmacological Actions
:
Cytotoxic : CK(73) : AC(35)
The mechanism behind bisphosphonate's supposedly therapeutic activity in bone may also underlie the mechanism of nephrotoxicity.
Click here to read the entire abstract
Pubmed Data
: Toxicol In Vitro. 2008 Jun;22(4):899-909. Epub 2008 Jan 26. PMID:
18325729
Article Published Date
: Jun 01, 2008
Study Type
: In Vitro Study
Additional Links
Diseases
:
Kidney Damage : CK(120) : AC(42)
,
Kidney Damage: Drug-Induced : CK(86) : AC(22)
Problem Substances
:
Bisphosphonates : CK(496) : AC(61)
,
Ibandronate : CK(2) : AC(2)
,
Pamidronate : CK(33) : AC(6)
,
Zoledronic Acid : CK(69) : AC(13)
Zolendronate is cytotoxic to human periodontal fibroblasts, which confirms its link to osteonecrosis.
Click here to read the entire abstract
Pubmed Data
: J Dent Res. 2010 Jan;89(1):40-5. PMID:
19948943
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Diseases
:
Osteonecrosis : CK(112) : AC(16)
Problem Substances
:
Zoledronic Acid : CK(69) : AC(13)
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