Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report.
Pediatr Neurol. 2015 May ;52(5):544-7. Epub 2015 Feb 19. PMID: 25882081
BACKGROUND: Malignant migrating partial seizures in infancy is a devastating pharmacoresistent epileptic encephalopathy of unknown etiology characterized by onset in the first 6 months of life, continuous migrating focal seizures with corresponding multifocal electroencephalographic discharges, developmental deterioration, and early mortality. Recent widespread interest in the nonpsychoactive component of the cannabis plant, cannabidiol, as a potential treatment for refractory devastating epilepsies has led to individual trials initiated by families or physicians in states that have legalized medical marijuana with anecdotal success.
PATIENT DESCRIPTION: We describe a now 10-month-old boy with malignant migrating partial seizures in infancy who made developmental gains and demonstrated sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen.
CONCLUSION: This report supports a role for cannabidiol in the treatment of malignant migrating partial seizures in infancy.