n/a
Article Publish Status: FREE
Abstract Title:

11-Keto-α-Boswellic Acid, a Novel Triterpenoid fromspp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells.

Abstract Source:

Molecules. 2021 Jan 12 ;26(2). Epub 2021 Jan 12. PMID: 33445710

Abstract Author(s):

Michael Schmiech, Judith Ulrich, Sophia Johanna Lang, Berthold Büchele, Christian Paetz, Alexis St-Gelais, Tatiana Syrovets, Thomas Simmet

Article Affiliation:

Michael Schmiech

Abstract:

Boswellic acids, and particularly 11-keto-boswellic acids, triterpenoids derived from the genus(), are known for their anti-inflammatory and potential antitumor efficacy. Although boswellic acids generally occur asα-isomers (oleanane type) and β-isomers (ursane type), 11-keto-boswellic acid (KBA) was found only as the β-isomer, β-KBA. Here, the existence and natural occurrence of the respective α-isomer, 11-keto-α-boswellic acid (α-KBA), is demonstrated for the first time. Initially, α-KBA was synthesized and characterized by high-resolution mass spectrometry (HR-MS) and nuclear magnetic resonance (NMR) spectroscopy, and a highly selective, sensitive, and accurate high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) method was developed by Design of Experiments (DoE) using a pentafluorophenyl stationary phase. This method allowed the selective quantification of individual 11-keto-boswellic acids and provided evidence for α-KBA inspp. oleogum resins. The contents ofα-KBA as well as further boswellic acids and the composition of essential oils were used to chemotaxonomically classify 41oleogum resins from 9 different species. Moreover,α-KBA exhibited cytotoxicity against three treatment-resistant triple-negative breast cancer (TNBC) cell lines in vitro and also induced apoptosis in MDA-MB-231 xenografts in vivo. The respective β-isomer and the acetylated form demonstrate higher cytotoxic efficacies against TNBC cells. This provides further insights into the structure-activity relationship of boswellic acids and could support future developments of potential anti-inflammatory and antitumor drugs.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.