n/a
Abstract Title:

50-Hz magnetic field impairs the expression of iron-related genes in the in vitro SOD1model of amyotrophic lateral sclerosis.

Abstract Source:

Int J Radiat Biol. 2019 03 ;95(3):368-377. Epub 2019 Jan 4. PMID: 30513241

Abstract Author(s):

Claudia Consales, Martina Panatta, Alessio Butera, Giuseppe Filomeni, Caterina Merla, Maria Teresa Carrì, Carmela Marino, Barbara Benassi

Article Affiliation:

Claudia Consales

Abstract:

PURPOSE: We characterized the response to the extremely low frequency magnetic field (ELF-MF) in an in vitro model of familial Amyotrophic Lateral Sclerosis (fALS), carrying two mutant variants of the superoxide dismutase 1 (SOD1) gene.

MATERIALS AND METHODS: SH-SY5Y human neuroblastoma cells, stably over-expressing the wild type, the G93A or the H46R mutant SOD1 cDNA, were exposed to either the ELF-MF (50 Hz, 1 mT) or the sham control field, up to 72 h. Analysis of (i) viability, proliferation and apoptosis, (ii) reactive oxygen species generation, and (iii) assessment of the iron metabolism, were carried out in all clones in response to the MF exposure.

RESULTS: We report that 50-Hz MF exposure induces: (i) no change in proliferation and viability; (ii) no modulation of the intracellular superoxide and HOlevels; (iii) a significant deregulation in the expression of iron-related genes IRP1, MFRN1 and TfR1, this evidence being exclusive for the SOD1clone and associated with a slight (p = .0512) difference in the total iron content.

CONCLUSIONS: 50-Hz MF affects iron homeostasis in the in vitro SOD1ALS model.

Study Type : Human In Vitro

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.