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Abstract Title:

[6]-Gingerol exhibits potent anti-mycobacterial and immunomodulatory activity against tuberculosis.

Abstract Source:

Int Immunopharmacol. 2020 Jul 18 ;87:106809. Epub 2020 Jul 18. PMID: 32693356

Abstract Author(s):

Ashima Bhaskar, Anjna Kumari, Mona Singh, Santosh Kumar, Suresh Kumar, Ankita Dabla, Shivam Chaturvedi, Vinod Yadav, Debprasad Chattopadhyay, Ved Prakash Dwivedi

Article Affiliation:

Ashima Bhaskar

Abstract:

The currently available anti-tuberculosis treatment (ATT) comprises exclusively of anti-bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the generation of drug-resistant variants. Therefore, a combination therapy directed against the pathogen and the host is required to counter tuberculosis (TB). Here we demonstrate that [6]-Gingerol, one of the most potent and pharmacologically active ingredients of ginger restricted mycobacterial growth inside the lungs, spleen and liver of mice infected with Mycobacterium tuberculosis (Mtb). The spleen of [6]-Gingerol treated mice displayed increased expression of pro-inflammatory cytokines and enhanced Th1/Th17 responses confirming the immunomodulatory action of [6]-Gingerol. Finally, [6]-Gingerol displayed an excellent potential as an adjunct drug, along with front line anti-TB drug isoniazid. Interestingly, [6]-Gingerol displayed stark anti-tubercular activity against dormant/starved bacilli and drug-resistant variants of Mtb. Taken together, these results indicate strong prospects of [6]-Gingerol as an adjunct anti-mycobacterial and immunomodulatory drug for the treatment of drug-susceptible and drug-resistant strains of TB.

Study Type : In Vitro Study

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