6-Gingerol inhibits proliferation in gastric cancer via the STAT3 pathway in vitro. - GreenMedInfo Summary
6-Gingerol inhibits proliferation in gastric cancer via the STAT3 pathway in vitro.
Cell Mol Biol (Noisy-le-grand). 2019 Mar 31 ;65(3):109-113. Epub 2019 Mar 31. PMID: 30942163
With high incidence and mortality, gastric cancer seriously threatened human's life. It is arduous and necessary to investigate its pathogenesis and dig effective drugs. In this study, we explored the role of 6-Gingerol (GI), a natural active ingredient, in treating gastric cancer cells. MTT assay and colony formation assay were utilized to confirmed that GI can control the proliferation of gastric cancer cells, which is time and concentration-dependent to some extent. The Annexin V-FITC/PI staining results by flow cytometry reveal that GI induces the apoptosis of gastric cancer cells. And a study on further pathways by western blot shows that GI brings about cell apoptosis by inhibiting the activation of STAT3. GI therefore may be a good candidate for treating gastric cancer.