75% of children<2 years old tested for celiac serology who were found positive for deamidated gliadin peptide (DGP) antibodies had negative results for tissue transglutaminase IgA. - GreenMedInfo Summary

Abstract Title:

Positive deamidated gliadin peptide antibodies and negative tissue transglutaminase IgA antibodies in a pediatric population: to biopsy or not to biopsy.

Abstract Source:

Clin Vaccine Immunol. 2010 May;17(5):884-6. Epub 2010 Mar 31. PMID: 20357057

Abstract Author(s):

Miriam Parizade, Bracha Shainberg

Article Affiliation:

Maccabi Health Services, Central Laboratory, 9 Hamada St., Tamar Industrial Park, Rechovot 76302, Israel. [email protected]

Abstract:

Reports from our clinical laboratory database show that 75% of children<2 years old tested for celiac serology who were found positive for deamidated gliadin peptide (DGP) antibodies had negative results for tissue transglutaminase IgA. DGP levels were shown to decline and disappear without a gluten-free diet. This observation questions DGP's specificity for diagnosis of celiac disease.

Article Published Date : May 01, 2010
Study Type : Human Study
Additional Links
Diseases : Celiac Disease: Diagnostic Considerations : CK(104) : AC(14)

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Key Research Topics

Disease

Celiac Disease: Diagnostic Considerations

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