A.camphorata mycelia and antrodin A might be potential to use as anti-HSV agents. - GreenMedInfo Summary
Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia.
Antivir Ther. 2015 Aug 27. Epub 2015 Aug 27. PMID: 26313544
BACKGROUND: Antrodia camphorata, known as a Traditional Chinese Medicine (TCM), are widely used in treatment liver diseases and cancers. Besides those important activities, other biological activities, such as anti-inflammatory have been described. Herpes simplex virus infections represent one of the most serious public health concerns globally because of their devastating impact. Searching for new antiviral agents, especially those with different mechanisms of action, is a crucial goal and an unmet need for alternative and complementary therapy against HSV infection. In this study, an antiherpes screening was performed to obtained extracts from A. camphorata mycelia.
METHODS: MTT method and FIC theorem and median-effect principle were used to evaluate anti-viral activity and calculate drug combination effect.
RESULTS: The crude ethanol extracts and isolated constituents showed inhibition of HSV replication at very low concentration. Fraction A and antrodin A showed viral inhibitory effect with reduction of viral cell-to-cell spread. In addition, neither fraction A nor antrodin A showed interaction in combination with acyclovir.
CONCLUSIONS: A.camphorata mycelia and antrodin A might be potential to use as anti-HSV agents and promising for future antiviral drug design.