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Abstract Title:

Acupuncture Treatment of Delirium in Older Adults Hospitalized in Internal Medicine Departments: An Open-Label Pragmatic Randomized-Controlled Trial.

Abstract Source:

J Geriatr Psychiatry Neurol. 2021 Mar 9:891988721996804. Epub 2021 Mar 9. PMID: 33685268

Abstract Author(s):

Ilana Levy, Sagi Gavrieli, Talia Hefer, Samuel Attias, Ariel Schiff, Ron Oliven, Shikma Wisberg-Levi, Rina Hanchinsky, Elad Schiff

Article Affiliation:

Ilana Levy

Abstract:

BACKGROUND: Acupuncture seems to improve cognitive function in experimental models and to reduce agitation in dementia. The addition of acupuncture to standard-of-care (SOC) may improve clinical outcomes related to delirium in hospitalized older adults.

METHODS: This pragmatic open-label randomized-controlled trial evaluated 81 older adults hospitalized in an internal medicine ward and diagnosed with delirium. Fifty were randomized to daily acupuncture combined with SOC and 31 to SOC only for up to 1 week. Delirium was diagnosed using Confusion Assessment Method (CAM) tool, and its severity was assessed by the long CAM-Severity (CAM-S) tool. The primary study outcome was delirium resolution evaluated as time-to-first delirium remission (over 7 days) and the number of days spent delirium-free.

RESULTS: Time-to-first delirium remission was shorter in the acupuncture arm as compared to the SOC only arm (p<0.001). A multivariate Cox regression analysis showed a shorter time-to-first remission of delirium in the acupuncture arm as compared with SOC arm [Hazard Ratio 0.267 (95% CI 0.098-0.726, p = 0.010)]. In the 7 days of evaluation, a significantly higher number of delirium-free days was found in the acupuncture arm compared to the SOC arm (p<0.001), and CAM-S sum from day 2 to day 7 of evaluation was significantly lower in the acupuncture group compared to the control group (p = 0.002). No adverse safety event was found in the acupuncture group.

CONCLUSION: Acupuncture seems to be safe and effective in the treatment of delirium in older patients hospitalized in internal medicine departments.

Study Type : Human Study
Additional Links
Therapeutic Actions : Acupuncture : CK(3141) : AC(370)

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