Acute cholestatic hepatitis associated with pravastatin has been reported. - GreenMedInfo Summary

Abstract Title:

Acute cholestatic hepatitis associated with pravastatin.

Abstract Source:

Am J Gastroenterol. 1999 May ;94(5):1388-90. PMID: 10235223

Abstract Author(s):

M Hartleb, G Rymarczyk, K Januszewski

Article Affiliation:

Department of Gastroenterology, Silesian Medical School, Katowice, Poland.

Abstract:

A 57-yr-old man presented with clinical and laboratory signs of acute cholestatic hepatitis. Symptoms had appeared 7 wk after he was started on pravastatin 20 mg/day for hypercholesterolemia. A full evaluation including ultrasound, computed tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic nonobstructive jaundice. The liver function abnormalities normalized 7 wk after cessation of therapy. Pravastatin should be considered as a potential cause of cholestatic hepatitis with favorable clinical outcome after drug withdrawal.

Article Published Date : May 01, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(1157) : AC(504), Cholestasis : CK(125) : AC(36), GGT : CK(63) : AC(9), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(2126) : AC(382)
Problem Substances : Pravastatin : CK(251) : AC(42), Statin Drugs : CK(4369) : AC(517)
Adverse Pharmacological Actions : Hepatotoxic : CK(335) : AC(96)

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Key Research Topics

Pharmacological Actions

Anticholesteremic Agents

Disease

Statin-Induced Pathologies
Chemically-Induced Liver Damage
Cholestasis
GGT
Hepatitis: Cholestatic

Toxic Ingredients

Statin Drugs
Pravastatin

Adverse Pharmacological Actions

Hepatotoxic
Sayer Ji
Founder of GreenMedInfo.com

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