Acute supplementation with beetroot juice improves endothelial function in HIV-infected individuals.
Appl Physiol Nutr Metab. 2020 Aug 31. Epub 2020 Aug 31. PMID: 32866396
Rogerio Nogueira Soares
Human immunodeficiency virus (HIV) is associated with lower nitric oxide (NO) bioavailability and vascular dysfunction. Nitrate-rich beetroot juice (BJ) has been shown to acutely increase NO availability and vascular function in healthy and individuals at high risk for CVD . Thus, we tested the effects of BJ ingestion on flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in healthy and HIV-infected patients. 13 HIV-infected (36±10 years old) and 18 healthy (27±8 years old) participated in the study. Individuals were submitted to vascular tests such as FMD and pulse PWV at pre (T0) and at 120 min (T120) after beetroot juice (BJ) and placebo (PLA) ingestion. The %FMD at T0 of the control group was significantly higher than the %FMD at T0 of the HIV individuals in both interventions. BJ improved the %FMD at T120 when compared to T0 in the HIV and control groups. There was no change in %FMD after PLA ingestion in the control and HIV groups. There were no differences between groups (control vs HIV), time points (T0 vsT120) and interventions (BJ vs PLA) for PWV. Our findings showed that nitrate-rich beetroot juice ingestion acutely improved vascular function in healthy and HIV-infected patients. Clinical Trials Registry number: NCT03485248. Novelty bullets: ●Human immunodeficiency virus (HIV) is associated withlower nitric oxide (NO) bioavailability and vascular dysfunction. ●Acute supplementation with nitrate-rich beetroot juice (BJ) has been shown to acutely increases NO bioavailability ●We showed for the first time that BJ acutely improve endothelial function in HIV-infected patients.