Low Vitamin D Exposure is Associated with Higher Risk of Infection in Renal Transplant Recipients.
Clin Transplant. 2017 Mar 10. Epub 2017 Mar 10. PMID: 28295622
Hari V Kalluri
BACKGROUND: Vitamin-D is a steroid hormone with multiple vital roles within the immune system. Various studies evaluated the influence of vitamin-D on infections post-renal transplantation and found contrasting results. This study aims to assess the relationship between vitamin-D status and the incidence of infection in renal transplant recipients.
METHODS: This is a retrospective cohort study of adult renal transplant recipients at the University of Pittsburgh Medical Center between 2005 and 2012. Patients were grouped as vitamin-D sufficient (≥30 ng/mL) or deficient (<30 ng/mL) based on total serum 25-hydroxyvitamin-D concentrations. The association between vitamin D levels collected at any point post-transplantation and incidence of infection within±90 days of the vitamin-D levels were assessed using logistic and Poisson regression models.
RESULTS: Vitamin-D sufficiency at any point post-transplantation was significantly associated with a 66% lower odds (OR:0.34; 95% CI:0.22-0.52; p<0.001) and 43% lower rate of infections (IRR:0.57; 95% CI:0.46-0.71; p<0.001) within±90 days of the vitamin-D level. Baseline vitamin-D level was also associated with lower incidence and risk for infections within the first year post-transplantation.
CONCLUSION: Adequate levels of vitamin-D in kidney transplant recipients is associated with lower infection risk in the first year and at any time post-transplantation. This article is protected by copyright. All rights reserved.