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Article Publish Status: FREE
Abstract Title:

Administration ofBGN4 andBORI Improves Cognitive and Memory Function in the Mouse Model of Alzheimer's Disease.

Abstract Source:

Front Aging Neurosci. 2021 ;13:709091. Epub 2021 Aug 6. PMID: 34421576

Abstract Author(s):

Hongwon Kim, Sumin Kim, Sang-Jun Park, Gwoncheol Park, Hakdong Shin, Myeong Soo Park, Jongpil Kim

Article Affiliation:

Hongwon Kim

Abstract:

Recent evidence indicates that gut microbiota could interact with the central nervous system and affect brain function, including cognition and memory. In this study, we investigated whetherBGN4 (BGN4)BORI (BORI) alleviated the pathological features in a mouse model of Alzheimer's disease (AD). Administration ofBGN4 andBORI effectively suppressed amyloidosis and apoptotic processes and improved synaptic plasticity by ameliorating the neuroinflammatory response and BDNF expression. Moreover, behavioral tests indicated thatBGN4 andBORI attenuated the cognitive and memory disability of AD mice. Taken together, the present study highlights the therapeutic potential ofBGN4 andBORI for suppressing the pathological features of AD.

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