Gastroprotective Effects of Montelukast and Nigella Sativa Oil against Corticosteroids- Induced Gastric Damage: Much More Than Antiasthmatic Drugs.
Can J Physiol Pharmacol. 2017 Feb 10. Epub 2017 Feb 10. PMID: 28187265
Fatma Hassan Rizk
Corticosteroids are used to treat variety of diseases like bronchial asthma. However, long term corticosteroids have a gastric ulcerogenic potential. Montelukast (MTK) and nigella sativa oil (NSO) are used in treatment of bronchial asthma. Previous studies showed that MTK and NSO had gastroprotective effects in other models of gastric ulcer. The present study assesses synergistic gastroprotective effects of both drugs in dexamethasone (DXM)-induced gastric damage. 50 male rats were divided into 5 groups; normal control (I), DXM group (II), MTK+DXM group (III), NSO+DXM group (IV), MTK+NSO+DXM group (V). After 7 days, stomachs were removed for biochemical analysis and histological examinations. Significant increases in MDA level, SOD activity, MPO activity, and proliferating cell nuclear antigen (PCNA) positive cells, with significant decreases in mucus secretion were detected in DXM-treated group compared with group I. While, significant decreases of MDA level, MPO activity, and PCNA positive cells and significant increases in mucus secretion were detected in treated groups compared with group I and II. SOD activity significantly decreased in group V compared with group II only. We could conclude that administration of either MTK or NSO or both with DXM counteracts DXM induced-gastric lesions.