n/a
Article Publish Status: FREE
Abstract Title:

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats.

Abstract Source:

Asian J Sports Med. 2015 Sep ;6(3):e24901. Epub 2015 Sep 28. PMID: 26448855

Abstract Author(s):

Farzaneh Zeynali, Mehdi Nematbakhsh, Hossain Mojtahedi, Aliasghar Poorshahnazari, Ardeshir Talebi, Zahra Pezeshki, Safoora Mazaheri, Fatemeh Moslemi

Article Affiliation:

Farzaneh Zeynali

Abstract:

BACKGROUND: Cisplatin (CP) is a chemotherapy drug and nephrotoxicity is considered as its major side effect. Aerobic exercise is well known as an approach to reduce the side effects of many drugs.

OBJECTIVES: This study was designed to determine the protective role of aerobic exercise against CP-induced nephrotoxicity.

MATERIALS AND METHODS: Thirty male Wistar rats were randomly divided into four groups. Group I had aerobic exercise on a treadmill one hour per day and five days per week for eight weeks. Then, the exercise protocol was continued for another week, but during this week, the animals also received CP (2.5 mg/kg/day; ip). Group II underwent the same protocol as group I without exercise in the last week during the CP therapy. Groups III and IV were assigned as positive and negative control groups, and were treated with CP and saline without exercise, respectively. Finally, the animals were sacrificed for the biochemical measurement and tissue histopathology investigation.

RESULTS: CP alone without exercise increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and malondialdehyde (MDA); and kidney nitrite level, while treadmill exercise in group I significantly ameliorated these parameters (P<0.05). Kidney and serum levels of MDA and nitrite did not alter significantly. Also, the severity of kidney tissue damage decreased significantly in groups I and II (P<0.05).

CONCLUSIONS: Aerobic exercise may reduce CP-induced nephrotoxicity with a favorable effect on renal function by increasing activation of antioxidant system.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.