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Article Publish Status: FREE
Abstract Title:

Hepatoprotective effect of aged black garlic extract in rodents.

Abstract Source:

Toxicol Res. 2014 Mar ;30(1):49-54. PMID: 24795800

Abstract Author(s):

Jung Hyu Shin, Chang Woo Lee, Soo Jin Oh, Jieun Yun, Moo Rim Kang, Sang-Bae Han, Heungsik Park, Jae Chul Jung, Yoon Hoo Chung, Jong Soon Kang

Article Affiliation:

Jung Hyu Shin

Abstract:

In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.

Study Type : Animal Study

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Sayer Ji
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